Dr Claire O'Callaghan

Claire O'Callaghan

University position

Visiting postdoctoral fellow

Departments

Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Email

co365@cam.ac.uk

Research Theme

Cognitive and Behavioural Neuroscience

Interests

I am a clinical research fellow with a focus on neuropsychiatric symptoms in neurodegenerative conditions.

Symptoms such as apathy, depression, impulsivity and social impairments are common in neurodegenerative disease. My research takes a transdiagnostic approach across different conditions, including Parkinson’s disease, Huntington’s disease and frontotemporal dementia, to study neuropsychiatric symptoms. Drawing from both clinical and cognitive neurosciences, I aim to develop novel neuropsychological assessment tools to detect these symptoms, in combination with multimodal neuroimaging and pharmacological manipulations. Together, my goal is to refine our characterisation of these symptoms and better establish their neural basis, to ultimately improve therapeutic strategies.

Research Focus

Keywords

Neurodegeneration

Neuropsychiatry

Impulsivity

Apathy

Clinical conditions

Alzheimer's disease

Cognitive impairment

Dementia

Frontotemporal dementia

Huntington's disease

Parkinson's disease

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Trevor Robbins

Barbara Sahakian

United Kingdom

Michael Hornberger

International

Maxime Bertoux

John Hodges

Simon Lewis

Mac Shine

Associated News Items


    Publications

    2017

    Bertoux M, O’Callaghan C, Flanagan E & Hornberger M (2017), “Frontotemporal Dementia” In N.A. Pachana (Ed.), Encyclopedia of Geropsychology. Singapore: Springer Singapore. doi:10.1007/978-981-287-080-3_311-1

    Gellersen HM, Guo CC, O’Callaghan C, Tan RH, Sami S & Hornberger M (2017), “Cerebellar atrophy in neurodegeneration – a meta-analysis” Journal of Neurology, Neurosurgery and Psychiatry 88(9):780-788

    Muller AJ, O'Callaghan C, Walton CC, Shine JM & Lewis, SJG (2017), “Retrospective neuropsychological profile of patients with Parkinson disease prior to developing visual hallucinations” Journal of Geriatric Psychiatry and Neurology 30(2):90-95

    O'Callaghan C & Hornberger M (2017), “Towards a neurocomputational account of social dysfunction in neurodegenerative disease” Brain 140(3):e14-e14

    in press

    O'Callaghan C & Irish M (in press), “Candidate mechanisms of spontaneous cognition as revealed by dementia syndromes” In F Fox & K Christoff (Eds), The Oxford Handbook of Spontaneous Thought: Mind-wandering, Creativity, Dreaming, and Clinical Disorders

    O'Callaghan C & Lewis SJG (in press), “Cognition in Parkinson's disease” in “Non Motor Parkinson's: The Hidden Face”, edited by K Ray Chaudhuri and Nataliya Titova https://doi.org/10.1016/bs.irn.2017.05.002

    O'Callaghan C, Hall JM, Tomassini A, Muller AJ, Walpola IC, Moustafa AA, Shine JM & Lewis SJG (in press), “Visual hallucinations are characterised by impaired sensory evidence accumulation: Insights from hierarchical drift diffusion modelling in Parkinson’s disease” Biological Psychiatry: Cognitive Neuroscience and Neuroimaging DOI: http://dx.doi.org/10.1016/j.bpsc.2017.04.007

    2017

    O'Callaghan C, Kveraga K, Shine JM, Adams RB, Bar M (2017), “Predictions penetrate perception: Converging insights from brain, behaviour and disorder” Consciousness and Cognition 47:63-74

    in press

    Wong S, Irish M, O'Callaghan C, Kumfor F, Savage G, Hodges JR, Piguet O & Hornberger M (in press), “Should I trust you? Learning and memory of social interactions in dementia” Neuropsychologia

    2016

    Bertoux M, O’Callaghan C, Dubois B, Hornberger M (2016), “In two minds - executive functioning vs. theory of mind in behavioural variant frontotemporal dementia” Journal of Neurology, Neurosurgery and Psychiatry 87(3), 231-234

    Hall JM, Ehgoetz Martens KA, Walton CC, O'Callaghan C, Keller PE, Lewis SJG & Moustafa AA (2016), “Diffusion alterations associated with Parkinson's disease symptomatology: A review of the literature” Parkinsonism & Related Disorders 33, 12-26

    Hall JM, O'Callaghan C, Shine JM, Muller AJ, Phillips JR, Walton CC, Lewis SJG, Moustafa AA (2016), “Dysfunction in attentional processing in patients with Parkinson's disease and visual hallucinations” Journal of Neural Transmission 123(5), 503-507

    Irish M, Eyre N, Dermody N, O'Callaghan C, Hodges JR, Hornberger M & Piguet O (2016), “Neural Substrates of Semantic Prospection – Evidence from the Dementias” Frontiers in Behavioral Neuroscience 10:96

    O'Callaghan C, Bertoux M, Irish M, Shine JM, Wong S, Spiliopoulos L, Hodges JR, Hornberger M (2016), “Fair play: social norm compliance failures in behavioural variant frontotemporal dementia” Brain 139(1), 204-216

    O'Callaghan C, Hornberger M, Balsters JH, Halliday GM, Lewis SJG, Shine JM (2016), “Cerebellar atrophy in Parkinson’s disease and its implication for network connectivity” Brain 139(3), 845-855

    O'Callaghan C, Kveraga K, Shine JM, Adams RB, Bar M (2016), “Convergent evidence for top-down effects from the "predictive brain"” Behavioral and Brain Sciences 39

    2015

    Bell PT, Gilat M, O'Callaghan C, Copland DA, Frank MJ, Lewis SJ, Shine JM (2015), “Dopaminergic basis for impairments in functional connectivity across subdivisions of the striatum in Parkinson's disease.” Hum Brain Mapp 36(4):1278-91 Details

    Bertoux M, de Souza LC, O’Callaghan C, Greve A, Sarazin M, Dubois B Hornberger M (2015), “Social cognition: the key to distinguish behavioural variant frontotemporal dementia from Alzheimer disease regardless of amnesia?” Journal of Alzheimer’s Disease 49(4),1065-1074

    Bertoux M, O'Callaghan C, Flanagan E, Hodges JR, Hornberger M (2015), “Fronto-striatal atrophy in behavioural variant frontotemporal dementia & Alzheimer’s disease” Front Neurol 6:147

    Devenney E, Bartley L, Hoon C, O’Callaghan C, Kumfor F, Hornberger M, Kiernan MC, Halliday GM, Piguet O, Hodges JR. (2015), “Progression in behavioural variant frontotemporal dementia: a longitudinal study” JAMA Neurology 72(12):1501-1509

    Gilat M, Shine JM, Walton CC, O’Callaghan C, Hall JM, Lewis SJG (2015), “Brain activation underlying turning in Parkinson’s disease patients with and without Freezing of Gait: a virtual reality fMRI study” Npj Parkinson's Disease 1: 15020

    Hall JM, Shine JM, O’Callaghan C, Walton CC, Gilat M, Naismith SL, Lewis SJG (2015), “Freezing of Gait and its Associations in the Early and Advanced Clinical Motor Stages of Parkinson’s Disease: A Cross-Sectional Study” Journal of Parkinson’s Disease 5(4): 881-891

    O'Callaghan C, Shine JM, Lewis SJ, Andrews-Hanna JR, Irish M (2015), “Shaped by our thoughts--a new task to assess spontaneous cognition and its associated neural correlates in the default network.” Brain Cogn 93:1-10 Details

    Shine JM, Keogh R, O'Callaghan C, Muller AJ, Lewis SJ, Pearson J (2015), “Imagine that: elevated sensory strength of mental imagery in individuals with Parkinson's disease and visual hallucinations.” Proc Biol Sci 282(1798):20142047 Details

    Shine JM, Mills JMZ, Qiu J, O'Callaghan C, Terpening ZT, Halliday GM, Naismith SL, Lewis SJG (2015), “Validation of the Psychosis and Hallucinations Questionnaire in non-demented patients with Parkinson's disease” Mov Disord Clin Pract 2(2):175-81

    Shine JM, Muller AJ, O’Callaghan C, Hornberger M, Halliday GM, Lewis SJG (2015), “Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease: a task-based fMRI study” npj Parkinson’s Disease 1:15003

    Szeto JYY, O’Callaghan C, Shine JM, Walton CC, Mowszowski L, Naismith SL, Halliday GM, Lewis SJG (2015), “The relationships between mild cognitive impairment and phenotype in Parkinson’s disease” Npj Parkinson's Disease 1:15015

    Walton CC, O’Callaghan C, Hall JM, Gilat M, Mowszowski L, Naismith SL, Burrell JR, Shine JM, Lewis SJG (2015), “Antisaccade errors reveal cognitive control deficits in Parkinson's disease with freezing of gait” Journal of Neurology 262(12), 2745-2754

    Walton CC, Shine JM, Hall JM, O'Callaghan C, Mowszowski L, Gilat M, Szeto JY, Naismith SL, Lewis SJ (2015), “The major impact of freezing of gait on quality of life in Parkinson's disease.” J Neurol 262(1):108-15 Details

    Walton CC, Shine JM, Mowszowski L, Gilat M, Hall JM, O'Callaghan C, Naismith SL, Lewis SJ (2015), “Impaired cognitive control in Parkinson's disease patients with freezing of gait in response to cognitive load.” J Neural Transm 122(5):653-60 Details

    2014

    Kamminga J, O'Callaghan C, Hodges JR, Irish M (2014), “Differential prospective memory profiles in frontotemporal dementia syndromes.” J Alzheimers Dis 38(3):669-79 Details

    O'Callaghan C, Bertoux M, Hornberger M (2014), “Beyond and below the cortex: the contribution of striatal dysfunction to cognition and behaviour in neurodegeneration.” J Neurol Neurosurg Psychiatry 85(4):371-8 Details

    O'Callaghan C, Muller AJ, Shine JM (2014), “Clarifying the role of neural networks in complex hallucinatory phenomena.” J Neurosci 34(36):11865-7 Details

    O'Callaghan C, Shine JM, Lewis SJ, Hornberger M (2014), “Neuropsychiatric symptoms in Parkinson's disease: fronto-striatal atrophy contributions.” Parkinsonism Relat Disord 20(8):867-72 Details

    Shine JM, O'Callaghan C, Halliday GM, Lewis SJ (2014), “Tricks of the mind: Visual hallucinations as disorders of attention.” Prog Neurobiol 116:58-65 Details

    2013

    Bertoux M, Funkiewiez A, O'Callaghan C, Dubois B, Hornberger M (2013), “Sensitivity and specificity of ventromedial prefrontal cortex tests in behavioral variant frontotemporal dementia.” Alzheimers Dement 9(5 Suppl):S84-94 Details

    Kloeters S, Bertoux M, O'Callaghan C, Hodges JR, Hornberger M (2013), “Money for nothing - Atrophy correlates of gambling decision making in behavioural variant frontotemporal dementia and Alzheimer's disease.” Neuroimage Clin 2:263-72 Details

    Nguyen T, Bertoux M, O’Callaghan C, Ahmed S, Hodges JR, Hornberger M (2013), “Grey and white matter brain network changes in frontotemporal dementia subtypes” Translational Neuroscience 4(4)410-418

    O'Callaghan C, Hodges JR, Hornberger M (2013), “Inhibitory dysfunction in frontotemporal dementia: a review.” Alzheimer Dis Assoc Disord 27(2):102-8 Details

    O'Callaghan C, Hornberger M (2013), “Screening for impulse control symptoms in patients with de novo Parkinson disease: a case-control study.” Neurology 81(7):694-5 Details

    O'Callaghan C, Moustafa AA, de Wit S, Shine JM, Robbins TW, Lewis SJ, Hornberger M (2013), “Fronto-striatal gray matter contributions to discrimination learning in Parkinson's disease.” Front Comput Neurosci 7:180 Details

    O'Callaghan C, Naismith SL, Hodges JR, Lewis SJ, Hornberger M (2013), “Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia.” Cortex 49(7):1833-43 Details

    O'Callaghan C, Naismith SL, Shine JM, Bertoux M, Lewis SJ, Hornberger M (2013), “A novel bedside task to tap inhibitory dysfunction and fronto-striatal atrophy in Parkinson's disease.” Parkinsonism Relat Disord 19(9):827-30 Details

    2012

    Harris IM, Murray AM, Hayward WG, O'Callaghan C, Andrews S (2012), “Repetition blindness reveals differences between the representations of manipulable and nonmanipulable objects.” J Exp Psychol Hum Percept Perform 38(5):1228-41 Details