Professor Michael Bate
http://www.zoo.cam.ac.uk/zoostaf... (personal home page)
My research is concerned with the way in which the machinery underlying coordinated movement is genetically specified and assembled during embryonic development. On the one hand this involves an analysis of the way in which muscles are assembled, specified and patterned and on the other an investigation of the way in which motor circuits are generated and begin to function. We work with the fruitfly, Drosophila melanogaster and this means that, as a group, we can bring a combination of genetic, molecular and cellular techniques to bear on these fundamental issues of neuromuscular development.
No direct clinical relevance
Electrophysiological recording techniques
Whole cell patch clamp
K. VijayRaghavan Web: http://www.ncbs.res.in/vijay/g...
Dixit R, VijayRaghavan K, Bate M (2008), “Hox genes and the regulation of movement in Drosophila” Dev Neurobiol 68(3): 309-16
Zlatic M, Landgraf M, Bate M (2003), “Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system” Neuron 37:41-51
Suster ML, Bate M (2002), “Embryonic assembly of a central pattern generator without sensory input” Nature 416:174-178
Ruiz-Gómez M, Coutts N, Price A, Taylor MV, Bate M (2000), “Drosophila Dumbfounded: a myoblast attractant essential for fusion” Cell 102:189-198
Zlatic M, Li F, Strigini M, Grueber W, Bate M (2009), “Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis.” PLoS Biol 7(6):e1000135 Details
Crisp S, Evers JF, Fiala A, Bate M (2008), “The development of motor coordination in Drosophila embryos.” Development 135(22):3707-17 Details
Tripodi M, Evers JF, Mauss A, Bate M, Landgraf M (2008), “Structural homeostasis: compensatory adjustments of dendritic arbor geometry in response to variations of synaptic input.” PLoS Biol 6(10):e260 Details