Dr Clare Baker

Clare Baker

University position

Reader

Dr Clare Baker is pleased to consider applications from prospective PhD students.

Departments

Department of Physiology, Development and Neuroscience

Email

cvhb1@cam.ac.uk

Home page

http://www.pdn.cam.ac.uk/staff/b...

Research Theme

Developmental Neuroscience

Interests

We are investigating a broad range of questions relating to the development of neurogenic placodes and the neural crest, two embryonic cell populations in vertebrates that together build the entire peripheral nervous system. Neural crest cells also build much of the craniofacial skeleton.

Current projects include:

- the development of olfactory ensheathing glia

- the development and evolution of electroreceptors

- the role of Pax genes in neurogenic placode development

- the development and evolution of the neural crest-derived pharyngeal skeleton

Cross-section of the embryonic chicken olfactory bulb showing neural crest-derived olfactory ensheathing cells (green). (Blue, axons; red, low-affinity neurotrophin receptor.)
Cross-section of the embryonic chicken olfactory bulb showing neural crest-derived olfactory ensheathing cells (green). (Blue, axons; red, low-affinity neurotrophin receptor.)
Click image to view full-size

Research Focus

Keywords

development

evolution

neurogenic placodes

neural crest

sensory

Clinical conditions

Birth defects

Equipment

Immunohistochemistry

In ovo electroporation

In situ hybridisation

Microdissection

Microscopy

Collaborators

Cambridge

Robin Franklin

United Kingdom

Alan Burns Web: http://www.ucl.ac.uk/slms/pe...

Andrea Streit Web: http://www.kcl.ac.uk/schools...

International

Marianne Bronner Web: http://biology.caltech.edu/Members...

Marcus Davis Web: http://science.kennesaw.edu/~mdavi1...

Raj Ladher Web: http://www.cdb.riken.go.jp/en/02_r...

Filippo Rijli Web: http://www.fmi.ch/researc...

Eric Turner Web: http://www.uwpsychiatry.org/Results...

Publications

2014

Butts T, Modrell MS, Baker CV, Wingate RJ (2014), “The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non-teleost ray-finned fish.” Evol Dev 16(2):92-100 Details

Modrell MS, Hockman D, Uy B, Buckley D, Sauka-Spengler T, Bronner ME, Baker CV (2014), “A fate-map for cranial sensory ganglia in the sea lamprey.” Dev Biol 385(2):405-16 Details

Piotrowski T, Baker CV (2014), “The development of lateral line placodes: Taking a broader view.” Dev Biol Details

2013

Baker CV, Modrell MS, Gillis JA (2013), “The evolution and development of vertebrate lateral line electroreceptors.” J Exp Biol 216(Pt 13):2515-22 Details

Barraud P, St John JA, Stolt CC, Wegner M, Baker CV (2013), “Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons.” Biol Open 2(7):750-9 Details

Gillis JA, Modrell MS, Baker CV (2013), “Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton.” Nat Commun 4:1436 Details

Rhinn M, Miyoshi K, Watanabe A, Kawaguchi M, Ito F, Kuratani S, Baker CV, Murakami Y, Rijli FM (2013), “Evolutionary divergence of trigeminal nerve somatotopy in amniotes.” J Comp Neurol 521(6):1378-94 Details

2012

Gillis JA, Modrell MS, Northcutt RG, Catania KC, Luer CA, Baker CV (2012), “Electrosensory ampullary organs are derived from lateral line placodes in cartilaginous fishes.” Development Details

Modrell MS, Baker CV (2012), “Evolution of electrosensory ampullary organs: conservation of Eya4 expression during lateral line development in jawed vertebrates.” Evol Dev 14(3):277-85 Details

Modrell MS, Baker CVH (2012), “Evolution of electrosensory ampullary organs: conservation of Eya4 expression during lateral line development in jawed vertebrates.” Evol Dev 14(3): 277-285

O'Neill P, Mak SS, Fritzsch B, Ladher RK, Baker CV (2012), “The amniote paratympanic organ develops from a previously undiscovered sensory placode.” Nat Commun 3:1041 Details

Sabado V, Barraud P, Baker CV, Streit A (2012), “Specification of GnRH-1 neurons by antagonistic FGF and retinoic acid signaling.” Dev Biol 362(2):254-62 Details

2011

Gillis JA, Rawlinson KA, Bell J, Lyon WS, Baker CV, Shubin NH (2011), “Holocephalan embryos provide evidence for gill arch appendage reduction and opercular evolution in cartilaginous fishes.” Proc Natl Acad Sci U S A 108(4):1507-12 Details

Modrell MS, Bemis WE, Northcutt RG, Davis MC, Baker CV (2011), “Electrosensory ampullary organs are derived from lateral line placodes in bony fishes.” Nat Commun 2:496 Details

Modrell MS, Buckley D, Baker CV (2011), “Molecular analysis of neurogenic placode development in a basal ray-finned fish.” Genesis 49(4):278-94 Details

2010

Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ, Baker CV (2010), “Neural crest origin of olfactory ensheathing glia.” Proc Natl Acad Sci U S A 107(49):21040-5 Details

2008

Baker CV (2008), “The evolution and elaboration of vertebrate neural crest cells.” Curr Opin Genet Dev 18(6):536-43 Details

Baker CV, O'Neill P, McCole RB (2008), “Lateral line, otic and epibranchial placodes: developmental and evolutionary links?” J Exp Zoolog B Mol Dev Evol 310(4):370-83 Details

Dude CM, Kuan CY, Bradshaw JR, Greene ND, Relaix F, Stark MR, Baker CV (2008), “Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode.” Dev Biol Details

Xu H, Dude CM, Baker CV (2008), “Fine-grained fate maps for the ophthalmic and maxillomandibular trigeminal placodes in the chick embryo.” Dev Biol 317(1):174-86 Details

2007

Lassiter RN, Dude CM, Reynolds SB, Winters NI, Baker CV, Stark MR (2007), “Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance.” Dev Biol 308(2):392-406 Details

O'Neill P, McCole RB, Baker CV (2007), “A molecular analysis of neurogenic placode and cranial sensory ganglion development in the shark, Scyliorhinus canicula.” Dev Biol 304(1):156-81 Details

Schleiffarth JR, Person AD, Martinsen BJ, Sukovich DJ, Neumann A, Baker CV, Lohr JL, Cornfield DN, Ekker SC, Petryk A (2007), “Wnt5a is required for cardiac outflow tract septation in mice.” Pediatr Res 61(4):386-91 Details

2006

Martinsen BJ, Neumann AN, Frasier AJ, Baker CV, Krull CE, Lohr JL (2006), “PINCH-1 expression during early avian embryogenesis: implications for neural crest and heart development.” Dev Dyn 235(1):152-62 Details

2005

Lee VM, Bronner-Fraser M, Baker CV (2005), “Restricted response of mesencephalic neural crest to sympathetic differentiation signals in the trunk.” Dev Biol 278(1):175-92 Details

2004

von Bartheld CS, Baker CV (2004), “Nervus terminalis derived from the neural crest? A surprising new turn in a century-old debate.” Anat Rec B New Anat 278(1):12-3 Details

2002

Baker CV, Stark MR, Bronner-Fraser M (2002), “Pax3-expressing trigeminal placode cells can localize to trunk neural crest sites but are committed to a cutaneous sensory neuron fate.” Dev Biol 249(2):219-36 Details

Kious BM, Baker CV, Bronner-Fraser M, Knecht AK (2002), “Identification and characterization of a calcium channel gamma subunit expressed in differentiating neurons and myoblasts.” Dev Biol 243(2):249-59 Details

2001

Baker CV, Bronner-Fraser M (2001), “Vertebrate cranial placodes I. Embryonic induction.” Dev Biol 232(1):1-61 Details

2000

Baker CV, Bronner-Fraser M (2000), “Establishing neuronal identity in vertebrate neurogenic placodes.” Development 127(14):3045-56 Details

1999

Baker CV, Stark MR, Marcelle C, Bronner-Fraser M (1999), “Competence, specification and induction of Pax-3 in the trigeminal placode.” Development 126(1):147-56 Details

1997

Baker CV, Bronner-Fraser M (1997), “The origins of the neural crest. Part II: an evolutionary perspective.” Mech Dev 69(1-2):13-29 Details

Baker CV, Bronner-Fraser M (1997), “The origins of the neural crest. Part I: embryonic induction.” Mech Dev 69(1-2):3-11 Details

Baker CV, Bronner-Fraser M, Le Douarin NM, Teillet MA (1997), “Early- and late-migrating cranial neural crest cell populations have equivalent developmental potential in vivo.” Development 124(16):3077-87 Details

1995

Baker CV, Sharpe CR, Torpey NP, Heasman J, Wylie CC (1995), “A Xenopus c-kit-related receptor tyrosine kinase expressed in migrating stem cells of the lateral line system.” Mech Dev 50(2-3):217-28 Details