Dr Chris Heath

Interests

I am interested in understanding how pathology-related molecular and cellular changes in defined neuronal circuits affect behaviour and cognition in neurodegenerative diseases.

Research Focus

Keywords

Cognition

Motivation

Affect

Touchscreen

Clinical conditions

Alzheimer's disease

Dementia

Huntington's disease

Equipment

Behavioural analysis

Fluorescence microscopy

Immunohistochemistry

Microscopy

Collaborators

No collaborators listed

Associated News Items


    Publications

    2013

    Horner AE, Heath CJ, Hvoslef-Eide M, Kent BA, Kim CH, Nilsson SR, Alsiö J, Oomen CA, Holmes A, Saksida LM, Bussey TJ (2013), “The touchscreen operant platform for testing learning and memory in rats and mice.” Nat Protoc 8(10):1961-84 Details

    Oomen CA, Hvoslef-Eide M, Heath CJ, Mar AC, Horner AE, Bussey TJ, Saksida LM (2013), “The touchscreen operant platform for testing working memory and pattern separation in rats and mice.” Nat Protoc 8(10):2006-21 Details

    2012

    Horst NK, Heath CJ, Neugebauer NM, Kimchi EY, Laubach M, Picciotto MR (2012), “Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion.” Behav Brain Res 231(1):170-80 Details

    Romberg C, McTighe SM, Heath CJ, Whitcomb DJ, Cho K, Bussey TJ, Saksida LM (2012), “False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine.” Brain 135(Pt 7):2103-14 Details

    2011

    Wigestrand MB, Mineur YS, Heath CJ, Fonnum F, Picciotto MR, Walaas SI (2011), “Decreased α4β2 nicotinic receptor number in the absence of mRNA changes suggests post-transcriptional regulation in the spontaneously hypertensive rat model of ADHD.” J Neurochem 119(1):240-50 Details

    2010

    Heath CJ, Horst NK, Picciotto MR (2010), “Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence.” Physiol Behav 101(5):764-9 Details

    Heath CJ, King SL, Gotti C, Marks MJ, Picciotto MR (2010), “Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through α4/β2/α5 nicotinic acetylcholine receptors.” Neuropsychopharmacology 35(12):2324-38 Details

    2009

    Heath CJ, Picciotto MR (2009), “Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing.” Neuropharmacology 56 Suppl 1:254-62 Details

    Jacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J (2009), “Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents.” Biol Psychiatry 65(8):671-9 Details

    2007

    Jacobsen LK, Picciotto MR, Heath CJ, Frost SJ, Tsou KA, Dwan RA, Jackowski MP, Constable RT, Mencl WE (2007), “Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure.” J Neurosci 27(49):13491-8 Details

    Steiner RC, Heath CJ, Picciotto MR (2007), “Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII.” J Neurochem 103(2):666-78 Details