Dr Caroline Williams-Gray MRCP PhD

Caroline Williams-Gray

University position

Clinical Lecturer

Dr Caroline Williams-Gray MRCP PhD is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

chm27@cam.ac.uk

Home page

http://www.brc.cam.ac.uk

Research Themes

Clinical and Veterinary Neuroscience

Cognitive and Behavioural Neuroscience

Interests

My work focuses on cognitive dysfunction in Parkinson's disease. This is a common feature of the disease, with around half of patients developing dementia within the first 10 years from diagnosis, which has a devastating impact on quality of life of both the patients and their families. My research to date has used epidemiological methods to describe how cognitive problems evolve over time in a large community-based cohort of newly diagnosed Parkinson’s disease patients (the CamPaIGN study); explored the neurobiological basis of working memory and planning deficits through functional MRI studies; and identified key clinical and genetic predictors of dementia in Parkinson’s disease. I am now further investigating the mechanistic basis of dementia in PD. I am particularly interested in the role that inflammation and the immune response might play, and I am exploring this through a number of approaches including examination of post-mortem brains as well as in vivo studies in patients.

Research Focus

Keywords

Parkinson's disease

dementia

cognition

genetics

inflammation

Clinical conditions

Parkinson's disease

Equipment

Cross-sectional and cohort studies

Genotyping

Immunohistochemistry

Immunophenotyping

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Roger Barker

Carol Brayne

Menna Clatworthy

Alasdair Coles

Joanne Jones

Trevor Robbins

Stephen Sawcer

John Xuereb

United Kingdom

David Burn Web: http://www.ncl.ac.uk/nnp

Alison Yarnall Web: http://www.ncl.ac.uk/caru

International

Rob De Bie Web: https://www.amc.nl/web/Res...

Gert Geurtsen Web: https://www.amc.nl/web/Res...

Mike Nalls Web: http://www.grc.nia.nih.gov

Andrew Singleton Web: http://irp.nih.gov/

Associated News Items


Key publications

Velseboer DC, de Bie RMA, Wieske L, Evans JR, Mason SL, Foltynie T, Schmand B, de Haan RJ, Post B, Barker RA, Williams-Gray CH (in press), “Development and external validation of a prognostic model in newly-diagnosed Parkinson’s disease” Neurology

Williams-Gray CH, Wijeyekoon R, Yarnall AJ, Lawson RA, Breen DP, Evans JR, Cummins GE, Duncan GW, Khoo TK, Burn DJ, Barker RA (in press), “Serum immune markers and disease progression in an incident Parkinson’s disease cohort (ICICLE-PD)” Mov Disord

Williams-Gray CH, Mason SL, Evans JR, Foltynie T, Brayne C, Robbins TW, Barker RA (2013), “The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort.” J Neurol Neurosurg Psychiatry 84(11):1258-64 Details

Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, Brayne C, Kolachana BS, Weinberger DR, Sawcer SJ, Barker RA (2009), “The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort.” Brain 132(Pt 11):2958-69 Details

Williams-Gray CH, Hampshire A, Barker RA, Owen AM (2008), “Attentional control in Parkinson's disease is dependent on COMT val 158 met genotype.” Brain 131(Pt 2):397-408 Details

Goris A, Williams-Gray CH, Clark GR, Foltynie T, Lewis SJ, Brown J, Ban M, Spillantini MG, Compston A, Burn DJ, Chinnery PF, Barker RA, Sawcer SJ (2007), “Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease. Ann Neurol” [E-pub ahead of print] Details

Williams-Gray CH, Foltynie T, Brayne CE, Robbins TW, Barker RA (2007), “Evolution of cognitive dysfunction in an incident Parkinson's disease cohort.” Brain 130(Pt 7):1787-98 Details

Williams-Gray CH, Hampshire A, Robbins TW, Owen AM, Barker RA (2007), “Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease” J Neurosci 27:4832-4838 Details

Publications

2016

Barker RA, Williams-Gray CH (2016), “The spectrum of clinical features seen with alpha synuclein pathology” Neuropathol Appl Neurobiol 10.1111/nan.12303

Evans JR, Cummins G, Breen DP, Foltynie T, Mason SL, Brayne CE, Williams-Gray CH, Barker RA (2016), “Comparative epidemiology of incident Parkinson's disease in Cambridgeshire, UK” J Neurol Neurosurg Psychiatry 10.1136/jnnp-2015-312581

Williams-Gray CH (2016), “A new biomarker for Parkinson's disease? [commentary]” Mov Disord 31(1): 42

2015

Stephenson D, Hu MT, Romero K, Breen K, Burn D, Ben-Shlomo Y, Bhattaram A, Isaac M, Venuto C, Kubota K, Little MA, Friend S, Lovestone S, Morris HR, Grosset D, Sutherland M, Gallacher J, Williams-Gray C, Bain LJ, Aviles E, Marek K, Toga AW, Stark Y, Forrest Gordon M, Ford S (2015), “Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease” Journal of Parkinson's disease 5(3): 581-94

Williams-Gray C (2015), “Seeing Is Believing: Alpha-Synuclein Oligomers in Parkinson's Disease Brain [commentary]” Mov Disord 30(10): 1324

Winder-Rhodes SE. Barker RA, Williams-Gray CH (2015), “The pathological and prognostic heterogeneity of Mild Cognitive Impairment in Parkinson’s disease” Emre M, editor. Cognitive Impairment and Dementia in Parkinson’s Disease, 2nd Edition. Oxford University Press 223-240

2014

Barker RA, Williams-Gray CH (2014), “Mild Cognitive Impairment and Parkinson's Disease - Something to Remember.” Journal of Parkinson's disease 4(4): 651-56

Goldman JG, Williams-Gray C, Barker RA, Duda JE, Galvin JE (2014), “The spectrum of cognitive impairment in Lewy body diseases” Mov Disord 29(5): 608-21

Moore SF, Guzman NV, Mason SL, Williams-Gray CH, Barker RA (2014), “Which Patients with Parkinson's Disease Participate in Clinical Trials? One Centre's Experiences with a New Cell Based Therapy Trial (TRANSEURO)” Journal of Parkinson's disease 4(4): 671-76

Williams-Gray CH, Mason SL, Foltynie T, Barker RA (2014), “Anti-inflammatory drugs delay the onset of dementia in an incident Parkinson's disease cohort [abstract]” Mov Disord 29(Suppl 1): 1510

2013

Brayne C, Barker RA, Harold D, Ince PG, Savva GM, Williams J, Williams-Gray CH, Wharton SB (2013), “From molecule to clinic and community for neurodegeneration: research to bridge translational gaps.” J Alzheimers Dis 33 Suppl 1:S385-96 Details

Breen DP, Williams-Gray CH, Mason SL, Foltynie T, Barker RA (2013), “Excessive daytime sleepiness and its risk factors in incident Parkinson's disease.” J Neurol Neurosurg Psychiatry 84(2):233-4 Details

Fallon SJ, Hampshire A, Williams-Gray CH, Barker RA, Owen AM (2013), “Putative cortical dopamine levels affect cortical recruitment during planning.” Neuropsychologia 51(11):2194-201 Details

Fallon SJ, Williams-Gray CH, Barker RA, Owen AM, Hampshire A (2013), “Prefrontal dopamine levels determine the balance between cognitive stability and flexibility.” Cereb Cortex 23(2):361-9 Details

Hudson G, Nalls M, Evans JR, Breen DP, Winder-Rhodes S, Morrison KE, Morris HR, Williams-Gray CH, Barker RA, Singleton AB, Hardy J, Wood NE, Burn DJ, Chinnery PF (2013), “Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease.” Neurology 80(22):2042-8 Details

Klebe S, Golmard JL, Nalls MA, Saad M, Singleton AB, Bras JM, Hardy J, Simon-Sanchez J, Heutink P, Kuhlenbäumer G, Charfi R, Klein C, Hagenah J, Gasser T, Wurster I, Lesage S, Lorenz D, Deuschl G, Durif F, Pollak P, Damier P, Tison F, Durr A, Amouyel P, Lambert JC, Tzourio C, Maubaret C, Charbonnier-Beaupel F, Tahiri K, Vidailhet M, Martinez M, Brice A, Corvol JC, French Parkinson's Disease Genetics Study Group, International Parkinson's Disease Genomics Consortium (IPDGC) (2013), “The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism.” J Neurol Neurosurg Psychiatry 84(6):666-73 Details

Rittman T, Ghosh BC, McColgan P, Breen DP, Evans J, Williams-Gray CH, Barker RA, Rowe JB (2013), “The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.” J Neurol Neurosurg Psychiatry 84(5):544-51 Details

Williams-Gray CH, Barker RA. (2013), “The genetics of behaviour and cognition in Parkinson’s disease” In: Aarsland D, Weintraub D, Cummings J and Chaudhuri R, editors. Behavioral Problems in Parkinson's Disease & Related Movement Disorders: Cambridge University Press

Winder-Rhodes SE, Evans JR, Ban M, Mason SL, Williams-Gray CH, Foltynie T, Duran R, Mencacci NE, Sawcer SJ, Barker RA (2013), “Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort.” Brain 136(Pt 2):392-9 Details

2012

Kilarski LL, Pearson JP, Newsway V, Majounie E, Knipe MD, Misbahuddin A, Chinnery PF, Burn DJ, Clarke CE, Marion MH, Lewthwaite AJ, Nicholl DJ, Wood NW, Morrison KE, Williams-Gray CH, Evans JR, Sawcer SJ, Barker RA, Wickremaratchi MM, Ben-Shlomo Y, Williams NM, Morris HR (2012), “Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.” Mov Disord 27(12):1522-9 Details

Litvan I, Goldman JG, Tröster AI, Schmand BA, Weintraub D, Petersen RC, Mollenhauer B, Adler CH, Marder K, Williams-Gray CH, Aarsland D, Kulisevsky J, Rodriguez-Oroz MC, Burn DJ, Barker RA, Emre M (2012), “Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines.” Mov Disord 27(3):349-56 Details

McColgan P, Evans JR, Breen DP, Mason SL, Barker RA, Williams-Gray CH (2012), “Addenbrooke's Cognitive Examination-Revised for mild cognitive impairment in Parkinson's disease.” Mov Disord 27(9):1173-7 Details

Williams-Gray CH, Mason SL (2012), “Neuropsychological features of early cognitive impairment in Parkinson’s disease” In: Ebmeier KP, O’Brien J, Taylor JP, editors. Psychiatry of Parkinson's disease. Advances in Biological Psychiatry. Basel: Karger Vol 27:84-102

Winder-Rhodes SE, Garcia-Reitböck P, Ban M, Evans JR, Jacques TS, Kemppinen A, Foltynie T, Williams-Gray CH, Chinnery PF, Hudson G, Burn DJ, Allcock LM, Sawcer SJ, Barker RA, Spillantini MG (2012), “Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome.” Mov Disord 27(2):312-5 Details

2011

Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Brayne C, Robbins TW, Barker RA (2011), “The natural history of treated Parkinson's disease in an incident, community based cohort.” J Neurol Neurosurg Psychiatry Details

Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Trotter M, Barker RA (2011), “The factor structure of the UPDRS as an index of disease progression in Parkinson's disease.” J Parkinsons Dis 1(1):75-82 Details

International Parkinson Disease Genomics Consortium, Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW (2011), “Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.” Lancet 377(9766):641-9 Details

International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2) (2011), “A two-stage meta-analysis identifies several new loci for Parkinson's disease.” PLoS Genet 7(6):e1002142 Details

2010

Aarsland D, Bronnick K, Williams-Gray C, Weintraub D, Marder K, Kulisevsky J, Burn D, Barone P, Pagonabarraga J, Allcock L, Santangelo G, Foltynie T, Janvin C, Larsen JP, Barker RA, Emre M (2010), “Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis.” Neurology 75(12):1062-9 Details

Hoogland J, de Bie RM, Williams-Gray CH, Muslimović D, Schmand B, Post B (2010), “Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.” Mov Disord 25(15):2550-4 Details

Rowe JB, Hughes L, Williams-Gray CH, Bishop S, Fallon S, Barker RA, Owen AM (2010), “The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.” Neurobiol Aging 31(6):1064-8 Details

Saiki M, Baker A, Williams-Gray CH, Foltynie T, Goodman RS, Taylor CJ, Compston DA, Barker RA, Sawcer SJ, Goris A (2010), “Association of the human leucocyte antigen region with susceptibility to Parkinson's disease.” J Neurol Neurosurg Psychiatry 81(8):890-1 Details

2009

Foltynie T, Cheeran B, Williams-Gray CH, Edwards MJ, Schneider SA, Weinberger D, Rothwell JC, Barker RA, Bhatia KP (2009), “BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease.” J Neurol Neurosurg Psychiatry 80(2):141-4 Details

Williams-Gray C, Goris A, Foltynie T, Compston A, Sawcer S, Barker RA (2009), “No evidence for association between an MAOA functional polymorphism and susceptibility to Parkinson's disease.” J Neurol 256(1):132-3 Details

Williams-Gray CH, Goris A, Saiki M, Foltynie T, Compston DA, Sawcer SJ, Barker RA (2009), “Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease.” J Neurol 256(3):493-8 Details

2008

Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM (2008), “Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition.” Brain 131(Pt 8):2094-105 Details

Wedderburn C, Wear H, Brown J, Mason SJ, Barker RA, Hodges J, Williams-Gray C (2008), “The utility of the Cambridge Behavioural Inventory in neurodegenerative disease.” J Neurol Neurosurg Psychiatry 79(5):500-3 Details

2007

Goris A, Williams-Gray CH, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Barker RA, Sawcer SJ (2007), “Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease.” J Neurol 254(7):846-8 Details

Williams-Gray CH, Aliyu SH, Lever AM, Dean AF, Lennox GG (2007), “Reversible parkinsonism in a patient with progressive multifocal leucoencephalopathy.” J Neurol Neurosurg Psychiatry 78(4):408-10 Details

Williams-Gray CH, Barker RA (2007), “Visual hallucinations predict increased benefits from rivastigmine in Parkinson's disease dementia.” Nat Clin Pract Neurol 3(5):250-1 Details

2006

Goris A, Williams-Gray CH, Foltynie T, Compston DA, Barker RA, Sawcer SJ (2006), “No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.” Am J Hum Genet 78(6):1088-90; author reply 1092-4 Details

Michell AW, Xu Z, Fritz D, Lewis SJ, Foltynie T, Williams-Gray CH, Robbins TW, Carpenter RH, Barker RA (2006), “Saccadic latency distributions in Parkinson's disease and the effects of L-dopa.” Exp Brain Res 174(1):7-18 Details

Williams-Gray C, Barker RA, Swainson R, Robbins TW (2006), “Cognitive dysfunction in early Parkinson's disease” In: Wolters EC, Berendse H, Stam C, editors. Mental Dysfunction in Parkinson's disease III: VU University Press 109-120

Williams-Gray CH, Foltynie T, Lewis SJ, Barker RA (2006), “Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options.” CNS Drugs 20(6):477-505 Details

Williams-Gray CH, Goris A, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Sawcer SJ, Barker RA (2006), “Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort.” J Neurol Neurosurg Psychiatry 77(5):665-7 Details

Williams-Gray CH, Goris A, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Sawcer SJ, Barker RA (2006), “No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.” Mov Disord 21(5):731-2 Details