Dr Belgin Yalcin

Belgin Yalcin

University position

Research Associate

Departments

Department of Genetics

Research Theme

Cellular and Molecular Neuroscience

Interests

Endoplasmic Reticulum (ER) forms a continuous network from the neuronal cell body, all the way to synaptic terminals. The formation and function of this elaborate structure of ER are not well understood. Importantly, the form of ER is highly relevant to its function; rough ER sheets are involved in protein synthesis, whereas smooth ER tubules maintain lipid metabolism and calcium handling. Mutations of proteins that generate the curvature of ER tubules are listed as the most frequent causes of a motor axon degeneration disease, Hereditary Spastic Paraplegia. However, the roles of these proteins in the organisation and function of axonal ER are not known. Using Drosophila, I have established the roles of ER-shaping proteins, Reticulons and Reeps, in the organisation of axonal ER, by discovering disrupted ER structure in mutant motor axons. These findings will help to understand why axonal ER is shaped in its particular form and how this is relevant to its role in axonal function.

Research Focus

Keywords

Axons

Endoplasmic Reticulum

Clinical conditions

Hereditary Spastic Paraplegia

No direct clinical relevance

Equipment

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Collaborators

No collaborators listed

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