Dr Brian Lam

University position

Research Associate

Institutes

Institute of Metabolic Science

Email

yhbl2@cam.ac.uk

Home page

http://mrl.ims.cam.ac.uk

Research Theme

Systems and Computational Neuroscience

Interests

I mainly work on genomic data generated from microarray experiments and I am particularly interested in the gene regulatory network of neural plasticity and functions.

Research Focus

Keywords

plasticity

gene expression regulation

gene regulatory network

Clinical conditions

No direct clinical relevance

Equipment

Computational modelling

Microarray

Collaborators

Cambridge

Sangeeta Chawla

Giles Yeo

International

Reynold Cheng Web: http://i.cs.hku.hk/~ckcheng/

Associated News Items


    Key publications

    Lam BY, Zhang W, Enticknap N, Haggis E, Cader MZ, Chawla S (2009), “Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons.” J Biol Chem Details

    Lam BY and Chawla S (2008), “Role of Signal-responsive Class II Histone Deacetylases in Regulating Neuronal Activity-dependent Gene Expression.” Regulation of Transcription by Neuronal Activity. S. M. Dudek, Springer Science, New York.

    Luk JM, Lam BY, Lee NP, Ho DW, Sham PC, Chen L, Peng J, Leng X, Day PJ, Fan ST (2007), “Artificial neural networks and decision tree model analysis of liver cancer proteomes.” Biochem Biophys Res Commun 361(1):68-73 Details

    Publications

    2008

    Lee NP, Leung KW, Cheung N, Lam BY, Xu MZ, Sham PC, Lau GK, Poon RT, Fan ST, Luk JM (2008), “Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma.” Proteomics 8(10):2136-49 Details

    2007

    Lam BY, Chawla S (2007), “MEF2D expression increases during neuronal differentiation of neural progenitor cells and correlates with neurite length.” Neurosci Lett 427(3):153-8 Details

    2006

    Luk JM, Lam CT, Siu AF, Lam BY, Ng IO, Hu MY, Che CM, Fan ST (2006), “Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values.” Proteomics 6(3):1049-57 Details

    Luk JM, Lee NP, Shum CK, Lam BY, Siu AF, Che CM, Tam PC, Cheung AN, Yang ZM, Lin YN, Matzuk MM, Lee KF, Yeung WS (2006), “Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis.” J Cell Physiol 209(3):755-66 Details

    Wang XQ, Luk JM, Garcia-Barcelo M, Miao X, Leung PP, Ho DW, Cheung ST, Lam BY, Cheung CK, Wong AS, Lau SS, So MT, Yu WC, Cai Q, Liu KS, Hui CK, Lau GK, Poon RT, Wong J, Fan ST (2006), “Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma.” Clin Cancer Res 12(17):5248-52 Details

    2004

    Mak DH, Chiu PY, Poon MK, Ng TT, Chung YK, Lam BY, Du Y, Ko KM (2004), “A yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects.” Phytother Res 18(7):525-30 Details

    2003

    Lam BY, Lo AC, Sun X, Luo HW, Chung SK, Sucher NJ (2003), “Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice.” Phytomedicine 10(4):286-91 Details

    2002

    Ko KM, Lam BY (2002), “Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain.” Mol Cell Biochem 238(1-2):181-6 Details

    Pan SY, Han YF, Carlier PR, Pang YP, Mak DH, Lam BY, Ko KM (2002), “Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.” Planta Med 68(3):217-20 Details