Dr Brian Lam
I mainly work on genomic data generated from microarray experiments and I am particularly interested in the gene regulatory network of neural plasticity and functions.
Associated News Items
Lam BY, Zhang W, Enticknap N, Haggis E, Cader MZ, Chawla S (2009), “Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons.” J Biol Chem Details
Lam BY and Chawla S (2008), “Role of Signal-responsive Class II Histone Deacetylases in Regulating Neuronal Activity-dependent Gene Expression.” Regulation of Transcription by Neuronal Activity. S. M. Dudek, Springer Science, New York.
Luk JM, Lam BY, Lee NP, Ho DW, Sham PC, Chen L, Peng J, Leng X, Day PJ, Fan ST (2007), “Artificial neural networks and decision tree model analysis of liver cancer proteomes.” Biochem Biophys Res Commun 361(1):68-73 Details
Lee NP, Leung KW, Cheung N, Lam BY, Xu MZ, Sham PC, Lau GK, Poon RT, Fan ST, Luk JM (2008), “Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma.” Proteomics 8(10):2136-49 Details
Lam BY, Chawla S (2007), “MEF2D expression increases during neuronal differentiation of neural progenitor cells and correlates with neurite length.” Neurosci Lett 427(3):153-8 Details
Luk JM, Lam CT, Siu AF, Lam BY, Ng IO, Hu MY, Che CM, Fan ST (2006), “Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values.” Proteomics 6(3):1049-57 Details
Luk JM, Lee NP, Shum CK, Lam BY, Siu AF, Che CM, Tam PC, Cheung AN, Yang ZM, Lin YN, Matzuk MM, Lee KF, Yeung WS (2006), “Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis.” J Cell Physiol 209(3):755-66 Details
Wang XQ, Luk JM, Garcia-Barcelo M, Miao X, Leung PP, Ho DW, Cheung ST, Lam BY, Cheung CK, Wong AS, Lau SS, So MT, Yu WC, Cai Q, Liu KS, Hui CK, Lau GK, Poon RT, Wong J, Fan ST (2006), “Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma.” Clin Cancer Res 12(17):5248-52 Details
Mak DH, Chiu PY, Poon MK, Ng TT, Chung YK, Lam BY, Du Y, Ko KM (2004), “A yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects.” Phytother Res 18(7):525-30 Details
Lam BY, Lo AC, Sun X, Luo HW, Chung SK, Sucher NJ (2003), “Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice.” Phytomedicine 10(4):286-91 Details
Ko KM, Lam BY (2002), “Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain.” Mol Cell Biochem 238(1-2):181-6 Details
Pan SY, Han YF, Carlier PR, Pang YP, Mak DH, Lam BY, Ko KM (2002), “Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.” Planta Med 68(3):217-20 Details