Dr Brian Billups

University position

Lecturer

Dr Brian Billups is pleased to consider applications from prospective PhD students.

Departments

Department of Pharmacology

Email

bjb41@cam.ac.uk

Home page

http://www.phar.cam.ac.uk/ri/bill...

Research Theme

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

My lab is interested in processes that modulate synaptic transmission. Using direct electrophysiological recordings from pre and postsynaptic cells in brain slices, combined with fluorescent ion imaging, we investigate release and recycling of neurotransmitter molecules.

Research Focus

Keywords

synapse

presynaptic

exocytosis

glutamate

glutamine

Clinical conditions

No direct clinical relevance

Equipment

Calcium imaging

Cell culture

Confocal microscopy

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Microscopy

Whole cell patch clamp

Collaborators

No collaborators listed

Key publications

Billups B (2005), “Colocalization of vesicular glutamate transporters in the rat superior olivary complex” Neuroscience Letters 382(1-2):66-70 Details

Billups B, Graham BP, Wong AY, Forsythe ID (2005), “Unmasking group III metabotropic glutamate autoreceptor function at excitatory synapses in the rat CNS” Journal of Physiology 565(Pt 3):885-96 Details

Billups B, Forsythe ID (2002), “ Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses” Journal of Neuroscience 22(14):5840-7

Publications

2009

Barker M, Billups B, Hamann M (2009), “Focal macromolecule delivery in neuronal tissue using simultaneous pressure ejection and local electroporation.” J Neurosci Methods 177(2):273-84 Details

Blot A, Billups D, Bjørkmo M, Quazi AZ, Uwechue NM, Chaudhry FA, Billups B (2009), “Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons.” Neuroscience 164(3):998-1008 Details

2006

Billups D, Billups B, Challiss RA, Nahorski SR (2006), “Modulation of Gq-protein-coupled inositol trisphosphate and Ca2+ signaling by the membrane potential.” J Neurosci 26(39):9983-95 Details

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