Dr Bianca Jupp

Interests

My research primarily concerns investigating the neurobiology underlying the behavioural trait of impulsivity and related cognitive endophenotypes and how these confer risk for developing drug abuse and addiction. I am particularly interested in the application of neuroimaging techniques such as MRI and PET in rodent models of these behaviours to facilitate such studies.

utoradiographic binding of D1, D2/D3, GABAA and mu-opoid receptors and the dopamine and serotonin transporters in the striatum of impulsive rats
utoradiographic binding of D1, D2/D3, GABAA and mu-opoid receptors, dopamine and serotonin transporters in the striatum of impulsive rats
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Research Focus

Keywords

Neuroimaging

Impulsivity

Behavioural Models

Cognitive Endophenotypes

Clinical conditions

Addiction

Attention deficit hyperactivity disorder

Equipment

Autoradiography

Behavioural analysis

Confocal microscopy

Fluorescence microscopy

Histology

Immunohistochemistry

Magnetic resonance imaging (MRI)

Microscopy

Positron Emission Tomography (PET)

Collaborators

Cambridge

John Apergis-Schoute

Jeff Dalley

Angela Roberts

Stephen Sawiak

International

Alon Chen Web: http://www.weizmann.ac.il/neurobi...

Andrew Lawrence Web: http://www.florey.edu.au/researc...

Patrick Riss Web: http://www.mn.uio.no/kjemi/e...

Associated News Items


Publications

2015

Barlow RL, Alsiö J, Jupp B, Rabinovich R, Shrestha S, Roberts AC, Robbins TW, Dalley JW (2015), “Markers of Serotonergic Function in the Orbitofrontal Cortex and Dorsal Raphé Nucleus Predict Individual Variation in Spatial-Discrimination Serial Reversal Learning.” Neuropsychopharmacology Details

Brown RM, Kim AK, Khoo SY, Kim JH, Jupp B, Lawrence AJ (2015), “Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats.” Addict Biol Details

Caprioli D, Jupp B, Hong YT, Sawiak SJ, Ferrari V, Wharton L, Williamson DJ, McNabb C, Berry D, Aigbirhio FI, Robbins TW, Fryer TD, Dalley JW (2015), “Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.” J Neurosci 35(9):3747-55 Details

Moreira FA, Jupp B, Belin D, Dalley JW (2015), “Endocannabinoids and striatal function: implications for addiction-related behaviours.” Behav Pharmacol 26(1-2):59-72 Details

2014

Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW (2014), “Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia.” Int J Neuropsychopharmacol 18(2) Details

Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2014), “Gamma Aminobutyric Acidergic and Neuronal Structural Markers in the Nucleus Accumbens Core Underlie Trait-like Impulsive Behavior.” Biol Psychiatry 75(2):115-23 Details

Chen NA, Jupp B, Sztainberg Y, Lebow M, Brown RM, Kim JH, Chen A, Lawrence AJ (2014), “Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice.” J Neurosci 34(35):11560-70 Details

Hayes DJ, Jupp B, Sawiak SJ, Merlo E, Caprioli D, Dalley JW (2014), “Brain γ-aminobutyric acid: a neglected role in impulsivity.” Eur J Neurosci Details

Jupp B, Dalley JW (2014), “Behavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies.” Neuropharmacology 76 Pt B:487-97 Details

Jupp B, Dalley JW (2014), “Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.” Br J Pharmacol 171(20):4729-66 Details

2013

Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW (2013), “Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.” Neuropsychopharmacology 38(8):1460-71 Details

Jupp B, Caprioli D, Dalley JW (2013), “Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction.” Dis Model Mech 6(2):302-11 Details

Jupp B, Caprioli D, Saigal N, Reverte I, Shrestha S, Cumming P, Everitt BJ, Robbins TW, Dalley JW (2013), “Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex.” Eur J Neurosci 37(9):1519-28 Details

2012

Jupp B, Williams J, Binns D, Hicks RJ, Cardamone L, Jones N, Rees S, O'Brien TJ (2012), “Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE.” Epilepsia 53(7):1233-44 Details

Virdee K, Cumming P, Caprioli D, Jupp B, Rominger A, Aigbirhio FI, Fryer TD, Riss PJ, Dalley JW (2012), “Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.” Neurosci Biobehav Rev 36(4):1188-216 Details

2011

Jupp B, Krivdic B, Krstew E, Lawrence AJ (2011), “The orexin₁ receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats.” Brain Res 1391:54-9 Details

Jupp B, Krstew E, Dezsi G, Lawrence AJ (2011), “Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin₁ receptors.” Br J Pharmacol 162(4):880-9 Details

2010

Jupp B, Lawrence AJ (2010), “New horizons for therapeutics in drug and alcohol abuse.” Pharmacol Ther 125(1):138-68 Details

2009

Hogan RE, Bouilleret V, Liu YR, Wang L, Williams JP, Jupp B, Myers D, O'Brien TJ (2009), “MRI-based large deformation high dimensional mapping of the hippocampus in rats: development and validation of the technique.” J Magn Reson Imaging 29(5):1027-34 Details

O'Brien TJ, Jupp B (2009), “In-vivo imaging with small animal FDG-PET: a tool to unlock the secrets of epileptogenesis?” Exp Neurol 220(1):1-4 Details

2007

Dedeurwaerdere S, Jupp B, O'Brien TJ (2007), “Positron Emission Tomography in basic epilepsy research: a view of the epileptic brain.” Epilepsia 48 Suppl 4:56-64 Details

Gantois I, Fang K, Jiang L, Babovic D, Lawrence AJ, Ferreri V, Teper Y, Jupp B, Ziebell J, Morganti-Kossmann CM, O'Brien TJ, Nally R, Schütz G, Waddington J, Egan GF, Drago J (2007), “Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior.” Proc Natl Acad Sci U S A 104(10):4182-7 Details

Jupp B, O'Brien TJ (2007), “Application of coregistration for imaging of animal models of epilepsy.” Epilepsia 48 Suppl 4:82-9 Details

2006

Jupp B, Williams JP, Tesiram YA, Vosmansky M, O'Brien TJ (2006), “MRI compatible electrodes for the induction of amygdala kindling in rats.” J Neurosci Methods 155(1):72-6 Details

Jupp B, Williams JP, Tesiram YA, Vosmansky M, O'Brien TJ (2006), “Hippocampal T2 signal change during amygdala kindling epileptogenesis.” Epilepsia 47(1):41-6 Details

2005

Stroud LM, O'Brien TJ, Jupp B, Wallengren C, Morris MJ (2005), “Neuropeptide Y suppresses absence seizures in a genetic rat model.” Brain Res 1033(2):151-6 Details

Wallengren C, Li S, Morris MJ, Jupp B, O'Brien TJ (2005), “Aggravation of absence seizures by carbamazepine in a genetic rat model does not induce neuronal c-Fos activation.” Clin Neuropharmacol 28(2):60-5 Details