Dr Benjamin Falcon
Filamentous protein assemblies in the brain characterize a large number of neurodegenerative diseases, the accumulation and spread of which is believed to underlie nerve cell degeneration. My research focuses on the mechanisms of amplification and spread of filamentous tau protein, a major hallmark of Alzheimer's disease, using cellular and in vitro models of propagation. Currently I am learning cryo-electron microscopy and helical reconstruction to investigate how the structures of filamentous tau protein obtained directly from human brain relate to disease.
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