Dr Benjamin Falcon


University position

Postdoctoral Scientist

Departments

Neurobiology Division

Institutes

Medical Research Council Laboratory of Molecular Biology

Email

bfalcon@mrc-lmb.cam.ac.uk

Research Theme

Cellular and Molecular Neuroscience

Interests

Filamentous protein assemblies in the brain characterize a large number of neurodegenerative diseases, the accumulation and spread of which is believed to underlie nerve cell degeneration. My research focuses on using electron cryo-microscopy (cryo-EM) and helical reconstruction to investigate how the structures of filamentous proteins obtained directly from human brain relate to disease. In addition, I use cellular and in vitro models to study the mechanisms of amplification and spread of filamentous tau protein, a major hallmark of Alzheimer's disease.

Research Focus

Keywords

neurodegeneration

tau

protein misfolding

prion-like propagation

cryo-EM

Clinical conditions

Alzheimer's disease

Dementia

Multiple system atrophy

Parkinson's disease

Prion diseases

Progressive supranuclear palsy

Traumatic brain injury

Equipment

Cell culture

Confocal microscopy

Electron cryo-microscopy (cryo-EM)

Immunogold-electron microscopy

Protein purification

Collaborators

Cambridge

Sjors Scheres

Associated News Items