Dr Benjamin Falcon

University position

Postdoctoral Scientist

Departments

Neurobiology Division

Institutes

Medical Research Council Laboratory of Molecular Biology

Email

bfalcon@mrc-lmb.cam.ac.uk

Research Theme

Cellular and Molecular Neuroscience

Interests

Filamentous protein assemblies in the brain characterize a large number of neurodegenerative diseases, the accumulation and spread of which is believed to underlie nerve cell degeneration. My research focuses on the mechanisms of amplification and spread of filamentous tau protein, a major hallmark of Alzheimer's disease, using cellular and in vitro models of propagation. Currently I am learning cryo-electron microscopy and helical reconstruction to investigate how the structures of filamentous tau protein obtained directly from human brain relate to disease.

Research Focus

Keywords

Neurodegeneration

Tau

Protein misfolding

Prion-like propagation

Clinical conditions

Alzheimer's disease

Dementia

Parkinson's disease

Prion diseases

Equipment

Cell culture

Confocal microscopy

Cryo-electron microscopy

Immunogold-electron microscopy

Protein purification

Collaborators

Cambridge

Anthony Fitzpatrick

Sjors Scheres

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