Professor Barbara Sahakian FMedSci

Barbara Sahakian

University position

Professor

Professor Barbara Sahakian FMedSci is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Institutes

Behavioural and Clinical Neuroscience Institute, Cambridge Centre for Brain Repair and Wolfson Brain Imaging Centre

Email

bjs-sec@medschl.cam.ac.uk

Home page

http://www.psychiatry.cam.ac.uk/pages/p... (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Clinical and Veterinary Neuroscience

Interests

My research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments. The focus of my lab is on early detection, differential diagnosis and proof of concept studies using cognitive enhancing drugs. This research utilises neuropsychological tests, such as the CANTAB tests, which I co-invented and a focus remains on the development of novel tests. Current study participants include healthy volunteers and patient groups with brain injury, Alzheimer’s disease, attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder, substance abuse, depression and mania. Techniques used include psychopharmacological, neuropsychological, neuroimaging (fMRI and PET) and genetic ones. Results from recent studies of ecstasy use and cognitive enhancement using methylphenidate, modafinil and atomoxetine have led to an interest in pharmacogenomics and neuroethics.

Research Focus

Keywords

cognitive psychopharmacology

clinical neuropsychology

neuropsychiatry

neuroimaging

neuroethics

Clinical conditions

Addiction

Alzheimer's disease

Attention deficit hyperactivity disorder

Bipolar disorder

Cognitive impairment

Dementia

Depressive disorders

Huntington's disease

Hydrocephalus

Obsessive compulsive disorder

Parkinson's disease

Schizophrenia

Traumatic brain injury

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Proof of concept trials

Psychopharmacology

Randomised control trials

Collaborators

Cambridge

Roger Barker

Ed Bullmore

Jonathan Dowson

Barry Everitt

Paul Fletcher

Ian Goodyer

John Hodges

David Menon

Peter Nestor

John Pickard

Trevor Robbins

Angela Roberts

David Rubinsztein

Judy Rubinsztein

United Kingdom

Rebecca Elliott Web: http://www.medicine.manchester.ac.uk/staff/1473

Naomi Fineberg Web: http://www.ocdaction.org.uk/ocdacti...

Eileen Joyce Web: http://www.icn.ucl.ac.uk/Staff-L...

Albert Michael Web: http://www.wsh.nhs.uk/Default...

Jonathan Roiser Web: http://www.icn.ucl.ac.uk/Staff-L...

International

Wayne Drevets Web: http://www.laureateinstitute.org/faculty...

Maura Furey Web: http://intramural.nimh.nih.gov/researc...

J. Leon Kenemans Web: http://www.fss.uu.nl/psn/web...

David Kupfer Web: http://www.upmc.com/Communi...

Mitul Mehta Web: http://rg.kcl.ac.uk/staffpr...

Mary Philips Web: http://www.wpic.pitt.edu/researc...

David Steffens Web: http://crtp.mc.duke.edu/faculty...

Key publications

Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006), “Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans” Science 311(5762):861-863 Details

Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003), “Cognitive enhancing effects of modafinil in healthy volunteers” Psychopharmacology 165(3):260-269

Swainson R, Galton CJ, Hodges JR, Michael A, Semple J, Dunn BD, Jefferies MC, Iddon JL, Robbins TW, Sahakian BJ (2001), “Early detection and differential diagnosis of Alzheimer’s disease and depression with neuropsychological tasks” Dementia and Geriatric Cognitive Disorders 12:265-280

Publications

2014

Clark-Elford R, Nathan PJ, Auyeung B, Voon V, Sule A, Müller U, Dudas R, Sahakian BJ, Phan KL, Baron-Cohen S (2014), “The effects of oxytocin on social reward learning in humans.” Int J Neuropsychopharmacol 17(2):199-209 Details

Fineberg NA, Chamberlain SR, Goudriaan AE, Stein DJ, Vanderschuren LJ, Gillan CM, Shekar S, Gorwood PA, Voon V, Morein-Zamir S, Denys D, Sahakian BJ, Moeller FG, Robbins TW, Potenza MN (2014), “New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity.” CNS Spectr 19(1):69-89 Details

Gillan CM, Morein-Zamir S, Durieux AM, Fineberg NA, Sahakian BJ, Robbins TW (2014), “Obsessive-compulsive disorder patients have a reduced sense of control on the illusion of control task.” Front Psychol 5:204 Details

Kehagia AA, Housden CR, Regenthal R, Barker RA, Müller U, Rowe J, Sahakian BJ, Robbins TW (2014), “Targeting impulsivity in Parkinson's disease using atomoxetine.” Brain 137(Pt 7):1986-97 Details

Owens M, Herbert J, Jones PB, Sahakian BJ, Wilkinson PO, Dunn VJ, Croudace TJ, Goodyer IM (2014), “Elevated morning cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms.” Proc Natl Acad Sci U S A Details

Pulcu E, Zahn R, Moll J, Trotter PD, Thomas EJ, Juhasz G, Deakin JF, Anderson IM, Sahakian BJ, Elliott R (2014), “Enhanced subgenual cingulate response to altruistic decisions in remitted major depressive disorder.” Neuroimage Clin 4:701-10 Details

Sahakian BJ (2014), “What do experts think we should do to achieve brain health?” Neurosci Biobehav Rev 43:240-58 Details

Voon V, Derbyshire K, Rück C, Irvine MA, Worbe Y, Enander J, Schreiber LR, Gillan C, Fineberg NA, Sahakian BJ, Robbins TW, Harrison NA, Wood J, Daw ND, Dayan P, Grant JE, Bullmore ET (2014), “Disorders of compulsivity: a common bias towards learning habits.” Mol Psychiatry Details

Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), “Improving Response Inhibition in Parkinson's Disease with Atomoxetine.” Biol Psychiatry Details

Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), “Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease.” Brain 137(Pt 4):1145-55 Details

2013

Als LC, Nadel S, Cooper M, Pierce CM, Sahakian BJ, Garralda ME (2013), “Neuropsychologic function three to six months following admission to the PICU with meningoencephalitis, sepsis, and other disorders: a prospective study of school-aged children.” Crit Care Med 41(4):1094-103 Details

Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, Armstrong RJ, Tyers P, Smith E, Carpenter A, Piccini P, Tai YF, Brooks DJ, Pavese N, Watts C, Pickard JD, Rosser AE, Dunnett SB, NEST-UK collaboration (2013), “The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease.” J Neurol Neurosurg Psychiatry 84(6):657-65 Details

Breitberg A, Drevets WC, Wood SE, Mah L, Schulkin J, Sahakian BJ, Erickson K (2013), “Hydrocortisone infusion exerts dose- and sex-dependent effects on attention to emotional stimuli.” Brain Cogn 81(2):247-55 Details

del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U (2013), “A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.” Brain 136(Pt 11):3252-70 Details

Fineberg NA, Haddad PM, Carpenter L, Gannon B, Sharpe R, Young AH, Joyce E, Rowe J, Wellsted D, Nutt DJ, Sahakian BJ (2013), “The size, burden and cost of disorders of the brain in the UK.” J Psychopharmacol 27(9):761-70 Details

Gillan CM, Morein-Zamir S, Kaser M, Fineberg NA, Sule A, Sahakian BJ, Cardinal RN, Robbins TW (2013), “Counterfactual Processing of Economic Action-Outcome Alternatives in Obsessive-Compulsive Disorder: Further Evidence of Impaired Goal-Directed Behavior.” Biol Psychiatry Details

Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Enhanced Avoidance Habits in Obsessive-Compulsive Disorder.” Biol Psychiatry Details

Goss AJ, Kaser M, Costafreda SG, Sahakian BJ, Fu CH (2013), “Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials.” J Clin Psychiatry 74(11):1101-7 Details

Hagan CC, Graham JM, Widmer B, Holt RJ, Ooi C, van Nieuwenhuizen AO, Fonagy P, Reynolds S, Target M, Kelvin R, Wilkinson PO, Bullmore ET, Lennox BR, Sahakian BJ, Goodyer I, Suckling J (2013), “Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT).” BMC Psychiatry 13:247 Details

Insel TR, Voon V, Nye JS, Brown VJ, Altevogt BM, Bullmore ET, Goodwin GM, Howard RJ, Kupfer DJ, Malloch G, Marston HM, Nutt DJ, Robbins TW, Stahl SM, Tricklebank MD, Williams JH, Sahakian BJ (2013), “Innovative solutions to novel drug development in mental health.” Neurosci Biobehav Rev 37(10 Pt 1):2438-44 Details

Morein-Zamir S, Papmeyer M, Durieux A, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Investigation of attentional bias in obsessive compulsive disorder with and without depression in visual search.” PLoS One 8(11):e80118 Details

Morein-Zamir S, Papmeyer M, Gillan CM, Crockett MJ, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task.” Psychol Med 43(2):391-400 Details

Morein-Zamir S, Papmeyer M, Pertusa A, Chamberlain SR, Fineberg NA, Sahakian BJ, Mataix-Cols D, Robbins TW (2013), “The profile of executive function in OCD hoarders and hoarding disorder.” Psychiatry Res Details

Müller U, Rowe JB, Rittman T, Lewis C, Robbins TW, Sahakian BJ (2013), “Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.” Neuropharmacology 64:490-5 Details

Nutt D, Gispen-de Wied CC, Arango C, Keefe RS, Penadés R, Murphy DG, Robbins TW, Sahakian BJ (2013), “Cognition in schizophrenia: Summary Nice Consultation Meeting 2012.” Eur Neuropsychopharmacol 23(8):769-78 Details

Pironti VA, Lai MC, Müller U, Dodds CM, Suckling J, Bullmore ET, Sahakian BJ (2013), “Neuroanatomical Abnormalities and Cognitive Impairments Are Shared by Adults with Attention-Deficit/Hyperactivity Disorder and Their Unaffected First-Degree Relatives.” Biol Psychiatry Details

Pulcu E, Trotter PD, Thomas EJ, McFarquhar M, Juhasz G, Sahakian BJ, Deakin JF, Zahn R, Anderson IM, Elliott R (2013), “Temporal discounting in major depressive disorder.” Psychol Med :1-10 Details

Roiser JP, Sahakian BJ (2013), “Hot and cold cognition in depression.” CNS Spectr 18(3):139-49 Details

Scoriels L, Jones PB, Sahakian BJ (2013), “Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain.” Neuropharmacology 64:168-84 Details

2012

Clark L, Boxer O, Sahakian BJ, Bilder RM (2012), “Research methods: cognitive neuropsychological methods.” Handb Clin Neurol 106:75-87 Details

Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, Ouden Hd, Apergis-Schoute A, Campbell-Meiklejohn D, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012), “Converging evidence for central 5-HT effects in acute tryptophan depletion.” Mol Psychiatry 17(2):121-3 Details

de Wit S, Standing HR, Devito EE, Robinson OJ, Ridderinkhof KR, Robbins TW, Sahakian BJ (2012), “Reliance on habits at the expense of goal-directed control following dopamine precursor depletion.” Psychopharmacology (Berl) 219(2):621-31 Details

Del Campo N, Müller U, Sahakian BJ (2012), “Neural and behavioral endophenotypes in ADHD.” Curr Top Behav Neurosci 11:65-91 Details

Insel TR, Sahakian BJ (2012), “Drug research: a plan for mental illness.” Nature 483(7389):269 Details

Maalouf FT, Clark L, Tavitian L, Sahakian BJ, Brent D, Phillips ML (2012), “Bias to negative emotions: a depression state-dependent marker in adolescent major depressive disorder.” Psychiatry Res 198(1):28-33 Details

Mohamed AD, Sahakian BJ (2012), “The ethics of elective psychopharmacology.” Int J Neuropsychopharmacol 15(4):559-71 Details

Murphy FC, Michael A, Sahakian BJ (2012), “Emotion modulates cognitive flexibility in patients with major depression.” Psychol Med 42(7):1373-82 Details

Owens M, Goodyer IM, Wilkinson P, Bhardwaj A, Abbott R, Croudace T, Dunn V, Jones PB, Walsh ND, Ban M, Sahakian BJ (2012), “5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.” PLoS One 7(11):e48482 Details

Robinson OJ, Cools R, Carlisi CO, Sahakian BJ, Drevets WC (2012), “Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder.” Am J Psychiatry 169(2):152-9 Details

Robinson OJ, Cools R, Sahakian BJ (2012), “Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience.” Psychopharmacology (Berl) 219(2):599-605 Details

Roiser JP, Elliott R, Sahakian BJ (2012), “Cognitive mechanisms of treatment in depression.” Neuropsychopharmacology 37(1):117-36 Details

Roiser JP, Levy J, Fromm SJ, Goldman D, Hodgkinson CA, Hasler G, Sahakian BJ, Drevets WC (2012), “Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers.” J Psychopharmacol 26(11):1434-42 Details

Scoriels L, Barnett JH, Soma PK, Sahakian BJ, Jones PB (2012), “Effects of modafinil on cognitive functions in first episode psychosis.” Psychopharmacology (Berl) 220(2):249-58 Details

Sugden C, Housden CR, Aggarwal R, Sahakian BJ, Darzi A (2012), “Effect of pharmacological enhancement on the cognitive and clinical psychomotor performance of sleep-deprived doctors: a randomized controlled trial.” Ann Surg 255(2):222-7 Details

Szanto K, Dombrovski AY, Sahakian BJ, Mulsant BH, Houck PR, Reynolds CF 3rd, Clark L (2012), “Social emotion recognition, social functioning, and attempted suicide in late-life depression.” Am J Geriatr Psychiatry 20(3):257-65 Details

2011

Cannon DM, Klaver JK, Gandhi SK, Solorio G, Peck SA, Erickson K, Akula N, Savitz J, Eckelman WC, Furey ML, Sahakian BJ, McMahon FJ, Drevets WC (2011), “Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.” Mol Psychiatry 16(4):407-18 Details

Chamberlain SR, Blackwell AD, Nathan PJ, Hammond G, Robbins TW, Hodges JR, Michael A, Semple JM, Bullmore ET, Sahakian BJ (2011), “Differential cognitive deterioration in dementia: a two year longitudinal study.” J Alzheimers Dis 24(1):125-36 Details

Chamberlain SR, Robbins TW, Winder-Rhodes S, Müller U, Sahakian BJ, Blackwell AD, Barnett JH (2011), “Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery.” Biol Psychiatry 69(12):1192-203 Details

Chase HW, Crockett MJ, Msetfi RM, Murphy RA, Clark L, Sahakian BJ, Robbins TW (2011), “5-HT modulation by acute tryptophan depletion of human instrumental contingency judgements.” Psychopharmacology (Berl) 213(2-3):615-23 Details

Clark L, Dombrovski AY, Siegle GJ, Butters MA, Shollenberger CL, Sahakian BJ, Szanto K (2011), “Impairment in risk-sensitive decision-making in older suicide attempters with depression.” Psychol Aging 26(2):321-30 Details

Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health, Anderson W, Dhansay MA, Phillips A, Shurin S, Walport M, Ewart W, Savill SJ, Bordin IA, Costello EJ, Durkin M, Fairburn C, Glass RI, Hall W, Huang Y, Hyman SE, Jamison K, Kaaya S, Kapur S, Kleinman A, Ogunniyi A, Otero-Ojeda A, Poo MM, Ravindranath V, Sahakian BJ, Saxena S, Singer PA, Stein DJ (2011), “Grand challenges in global mental health.” Nature 475(7354):27-30 Details

de Rover M, Pironti VA, McCabe JA, Acosta-Cabronero J, Arana FS, Morein-Zamir S, Hodges JR, Robbins TW, Fletcher PC, Nestor PJ, Sahakian BJ (2011), “Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task.” Neuropsychologia 49(7):2060-70 Details

Del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW (2011), “The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder.” Biol Psychiatry 69(12):e145-57 Details

del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD (2011), “Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.” Neuroimage 55(1):101-12 Details

Ersche KD, Roiser JP, Abbott S, Craig KJ, Müller U, Suckling J, Ooi C, Shabbir SS, Clark L, Sahakian BJ, Fineberg NA, Merlo-Pich EV, Robbins TW, Bullmore ET (2011), “Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist.” Biol Psychiatry 70(8):754-62 Details

Gillan CM, Papmeyer M, Morein-Zamir S, Sahakian BJ, Fineberg NA, Robbins TW, de Wit S (2011), “Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder.” Am J Psychiatry 168(7):718-26 Details

Gorodetzky H, Sahakian BJ, Robbins TW, Ersche KD (2011), “Differences in self-reported decision-making styles in stimulant-dependent and opiate-dependent individuals.” Psychiatry Res 186(2-3):437-40 Details

Kasahara M, Menon DK, Salmond CH, Outtrim JG, Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2011), “Traumatic brain injury alters the functional brain network mediating working memory.” Brain Inj 25(12):1170-87 Details

Maalouf FT, Brent D, Clark L, Tavitian L, McHugh RM, Sahakian BJ, Phillips ML (2011), “Neurocognitive impairment in adolescent major depressive disorder: state vs. trait illness markers.” J Affect Disord 133(3):625-32 Details

Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK (2011), “Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury.” Brain 134(Pt 3):759-68 Details

Sahakian BJ, Morein-Zamir S (2011), “Neuroethical issues in cognitive enhancement.” J Psychopharmacol 25(2):197-204 Details

Scoriels L, Barnett JH, Murray GK, Cherukuru S, Fielding M, Cheng F, Lennox BR, Sahakian BJ, Jones PB (2011), “Effects of modafinil on emotional processing in first episode psychosis.” Biol Psychiatry 69(5):457-64 Details

2010

Barnett JH, Robbins TW, Leeson VC, Sahakian BJ, Joyce EM, Blackwell AD (2010), “Assessing cognitive function in clinical trials of schizophrenia.” Neurosci Biobehav Rev 34(8):1161-77 Details

Chamberlain SR, Grant JE, Costa A, Müller U, Sahakian BJ (2010), “Effects of acute modafinil on cognition in trichotillomania.” Psychopharmacology (Berl) 212(4):597-601 Details

Chamberlain SR, Hampshire A, Menzies LA, Garyfallidis E, Grant JE, Odlaug BL, Craig K, Fineberg N, Sahakian BJ (2010), “Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study.” Arch Gen Psychiatry 67(9):965-71 Details

Chase HW, Camille N, Michael A, Bullmore ET, Robbins TW, Sahakian BJ (2010), “Regret and the negative evaluation of decision outcomes in major depression.” Cogn Affect Behav Neurosci 10(3):406-13 Details

Chase HW, Frank MJ, Michael A, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia.” Psychol Med 40(3):433-40 Details

Chase HW, Michael A, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Paradoxical enhancement of choice reaction time performance in patients with major depression.” J Psychopharmacol 24(4):471-9 Details

Dombrovski AY, Clark L, Siegle GJ, Butters MA, Ichikawa N, Sahakian BJ, Szanto K (2010), “Reward/Punishment reversal learning in older suicide attempters.” Am J Psychiatry 167(6):699-707 Details

Ersche KD, Bullmore ET, Craig KJ, Shabbir SS, Abbott S, Müller U, Ooi C, Suckling J, Barnes A, Sahakian BJ, Merlo-Pich EV, Robbins TW (2010), “Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.” Arch Gen Psychiatry 67(6):632-44 Details

Fineberg NA, Potenza MN, Chamberlain SR, Berlin HA, Menzies L, Bechara A, Sahakian BJ, Robbins TW, Bullmore ET, Hollander E (2010), “Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review.” Neuropsychopharmacology 35(3):591-604 Details

Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76 Details

Maalouf FT, Klein C, Clark L, Sahakian BJ, Labarbara EJ, Versace A, Hassel S, Almeida JR, Phillips ML (2010), “Impaired sustained attention and executive dysfunction: bipolar disorder versus depression-specific markers of affective disorders.” Neuropsychologia 48(6):1862-8 Details

Morein-Zamir S, Craig KJ, Ersche KD, Abbott S, Muller U, Fineberg NA, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation.” Psychopharmacology (Berl) 212(3):357-67 Details

Morein-Zamir S, Fineberg NA, Robbins TW, Sahakian BJ (2010), “Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?” Psychol Med 40(2):263-72 Details

Morein-Zamir S, Sahakian BJ (2010), “Neuroethics and public engagement training needed for neuroscientists.” Trends Cogn Sci 14(2):49-51 Details

Murthy NV, Selvaraj S, Cowen PJ, Bhagwagar Z, Riedel WJ, Peers P, Kennedy JL, Sahakian BJ, Laruelle MA, Rabiner EA, Grasby PM (2010), “Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.” Neuroimage 52(1):50-4 Details

Robinson OJ, Cools R, Crockett MJ, Sahakian BJ (2010), “Mood state moderates the role of serotonin in cognitive biases.” J Psychopharmacol 24(4):573-83 Details

Robinson OJ, Frank MJ, Sahakian BJ, Cools R (2010), “Dissociable responses to punishment in distinct striatal regions during reversal learning.” Neuroimage 51(4):1459-67 Details

Robinson OJ, Standing HR, DeVito EE, Cools R, Sahakian BJ (2010), “Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males.” Psychopharmacology (Berl) 211(2):187-95 Details

Sahakian BJ, Malloch G, Kennard C, Mental Health Review Group (2010), “A UK strategy for mental health and wellbeing.” Lancet 375(9729):1854-5 Details

Smith NJ, Marcus RE, Sahakian BJ, Kapur N, Cox TM (2010), “Haematopoietic stem cell transplantation does not retard disease progression in the psycho-cognitive variant of late-onset metachromatic leukodystrophy.” J Inherit Metab Dis 33 Suppl 3:S471-5 Details

Sugden C, Aggarwal R, Housden C, Sahakian BJ, Darzi A (2010), “Pharmacological enhancement of performance in doctors.” BMJ 340:c2542 Details

Winder-Rhodes SE, Chamberlain SR, Idris MI, Robbins TW, Sahakian BJ, Müller U (2010), “Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers.” J Psychopharmacol 24(11):1649-57 Details

2009

Chamberlain SR, Hampshire A, Müller U, Rubia K, Del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009), “Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study.” Biol Psychiatry 65(7):550-5 Details

Clark L, Chamberlain SR, Sahakian BJ (2009), “Neurocognitive mechanisms in depression: implications for treatment.” Annu Rev Neurosci 32:57-74 Details

Clark L, Roiser JP, Robbins TW, Sahakian BJ (2009), “Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users.” J Psychopharmacol 23(1):14-22 Details

DeVito EE, Blackwell AD, Clark L, Kent L, Dezsery AM, Turner DC, Aitken MR, Sahakian BJ (2009), “Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD).” Psychopharmacology (Berl) 202(1-3):531-9 Details

Lawrence AJ, Luty J, Bogdan NA, Sahakian BJ, Clark L (2009), “Impulsivity and response inhibition in alcohol dependence and problem gambling.” Psychopharmacology (Berl) 207(1):163-72 Details

Lawrence AJ, Luty J, Bogdan NA, Sahakian BJ, Clark L (2009), “Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals.” Addiction 104(6):1006-15 Details

Robinson OJ, Sahakian BJ (2009), “Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion.” Psychopharmacology (Berl) 205(2):227-35 Details

Robinson OJ, Sahakian BJ (2009), “A double dissociation in the roles of serotonin and mood in healthy subjects.” Biol Psychiatry 65(1):89-92 Details

Roiser JP, Cannon DM, Gandhi SK, Taylor Tavares J, Erickson K, Wood S, Klaver JM, Clark L, Zarate CA Jr, Sahakian BJ, Drevets WC (2009), “Hot and cold cognition in unmedicated depressed subjects with bipolar disorder.” Bipolar Disord 11(2):178-89 Details

Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC (2009), “The effects of tryptophan depletion on neural responses to emotional words in remitted depression.” Biol Psychiatry 66(5):441-50 Details

Sahakian BJ, Morein-Zamir S (2009), “Neuroscientists need neuroethics teaching.” Science 325(5937):147 Details

Slawik H, Salmond CH, Taylor-Tavares JV, Williams GB, Sahakian BJ, Tasker RC (2009), “Frontal cerebral vulnerability and executive deficits from raised intracranial pressure in child traumatic brain injury.” J Neurotrauma 26(11):1891-903 Details

2008

Beddington J, Cooper CL, Field J, Goswami U, Huppert FA, Jenkins R, Jones HS, Kirkwood TB, Sahakian BJ, Thomas SM (2008), “The mental wealth of nations.” Nature 455(7216):1057-60 Details

Blackwell AD, Paterson NS, Barker RA, Robbins TW, Sahakian BJ (2008), “The effects of modafinil on mood and cognition in Huntington's disease.” Psychopharmacology (Berl) 199(1):29-36 Details

Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008), “Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.” Science 321(5887):421-2 Details

Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K, Müller U, Robbins TW, Bullmore ET, Sahakian BJ (2008), “Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study.” Br J Psychiatry 193(3):216-21 Details

Chase HW, Clark L, Myers CE, Gluck MA, Sahakian BJ, Bullmore ET, Robbins TW (2008), “The role of the orbitofrontal cortex in human discrimination learning.” Neuropsychologia 46(5):1326-37 Details

Chase HW, Clark L, Sahakian BJ, Bullmore ET, Robbins TW (2008), “Dissociable roles of prefrontal subregions in self-ordered working memory performance.” Neuropsychologia 46(11):2650-61 Details

Clark L, Bechara A, Damasio H, Aitken MR, Sahakian BJ, Robbins TW (2008), “Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making.” Brain 131(Pt 5):1311-22 Details

Clark L, Sahakian BJ (2008), “Cognitive neuroscience and brain imaging in bipolar disorder.” Dialogues Clin Neurosci 10(2):153-63 Details

DeVito EE, Blackwell AD, Kent L, Ersche KD, Clark L, Salmond CH, Dezsery AM, Sahakian BJ (2008), “The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder.” Biol Psychiatry 64(7):636-9 Details

Ersche KD, Roiser JP, Robbins TW, Sahakian BJ (2008), “Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans.” Psychopharmacology (Berl) 197(3):421-31 Details

Holmes MK, Erickson K, Luckenbaugh DA, Drevets WC, Bain EE, Cannon DM, Snow J, Sahakian BJ, Manji HK, Zarate CA Jr (2008), “A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression.” Bipolar Disord 10(7):806-15 Details

Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008), “Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited.” Neurosci Biobehav Rev 32(3):525-49 Details

Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008), “White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives.” Am J Psychiatry 165(10):1308-15 Details

Ornstein TJ, Sahakian BJ, McKenna PJ (2008), “Memory and executive impairment in schizophrenia: comparison with frontal and temporal brain damage.” Psychol Med 38(6):833-42 Details

Robinson OJ, Sahakian BJ (2008), “Recurrence in major depressive disorder: a neurocognitive perspective.” Psychol Med 38(3):315-8 Details

Roiser JP, Levy J, Fromm SJ, Wang H, Hasler G, Sahakian BJ, Drevets WC (2008), “The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers.” Neuropsychopharmacology 33(8):1992-2006 Details

Taylor Tavares JV, Clark L, Furey ML, Williams GB, Sahakian BJ, Drevets WC (2008), “Neural basis of abnormal response to negative feedback in unmedicated mood disorders.” Neuroimage 42(3):1118-26 Details

2007

Barnett JH, Croudace TJ, Jaycock S, Blackwell C, Hynes F, Sahakian BJ, Joyce EM, Jones PB (2007), “Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling.” BMC Psychiatry 7:16 Details

Chamberlain SR, Del Campo N, Dowson J, Müller U, Clark L, Robbins TW, Sahakian BJ (2007), “Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder.” Biol Psychiatry 62(9):977-84 Details

Chamberlain SR, Fineberg NA, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2007), “A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania.” Neuropsychologia 45(4):654-62 Details

Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW, Sahakian BJ (2007), “Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder.” Am J Psychiatry 164(2):335-8 Details

Chamberlain SR, Menzies L, Sahakian BJ, Fineberg NA (2007), “Lifting the veil on trichotillomania.” Am J Psychiatry 164(4):568-74 Details

Chamberlain SR, Müller U, Cleary S, Robbins TW, Sahakian BJ (2007), “Atomoxetine increases salivary cortisol in healthy volunteers.” J Psychopharmacol 21(5):545-9 Details

Chamberlain SR, Müller U, Deakin JB, Corlett PR, Dowson J, Cardinal RN, Aitken MR, Robbins TW, Sahakian BJ (2007), “Lack of deleterious effects of buspirone on cognition in healthy male volunteers.” J Psychopharmacol 21(2):210-5 Details

Chamberlain SR, Robbins TW, Sahakian BJ (2007), “The neurobiology of attention-deficit/hyperactivity disorder.” Biol Psychiatry 61(12):1317-9 Details

Chamberlain SR, Sahakian BJ (2007), “The neuropsychiatry of impulsivity.” Curr Opin Psychiatry 20(3):255-61 Details

Clark L, Blackwell AD, Aron AR, Turner DC, Dowson J, Robbins TW, Sahakian BJ (2007), “Association between response inhibition and working memory in adult ADHD: a link to right frontal cortex pathology?” Biol Psychiatry 61(12):1395-401 Details

DeVito EE, Salmond CH, Owler BK, Sahakian BJ, Pickard JD (2007), “Caudate structural abnormalities in idiopathic normal pressure hydrocephalus.” Acta Neurol Scand 116(5):328-32 Details

Dowson JH, Blackwell AD, Turner DC, Harvey E, Malhotra T, Robbins TW, Sahakian BJ (2007), “Questionnaire ratings of attention-deficit/hyperactivity disorder (ADHD) in adults are associated with spatial working memory.” Eur Psychiatry 22(4):256-63 Details

Ersche KD, Sahakian BJ (2007), “The neuropsychology of amphetamine and opiate dependence: implications for treatment.” Neuropsychol Rev 17(3):317-36 Details

Lawrence AJ, Blackwell AD, Barker RA, Spagnolo F, Clark L, Aitken MR, Sahakian BJ (2007), “Predictors of punding in Parkinson's disease: results from a questionnaire survey.” Mov Disord 22(16):2339-45 Details

Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen CH, del Campo N, Sahakian BJ, Robbins TW, Bullmore E (2007), “Neurocognitive endophenotypes of obsessive-compulsive disorder.” Brain 130(Pt 12):3223-36 Details

Morein-Zamir S, Turner DC, Sahakian BJ (2007), “A review of the effects of modafinil on cognition in schizophrenia.” Schizophr Bull 33(6):1298-306 Details

Potter GG, Blackwell AD, McQuoid DR, Payne ME, Steffens DC, Sahakian BJ, Welsh-Bohmer KA, Krishnan KR (2007), “Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.” Neuropsychopharmacology 32(10):2135-42 Details

Roiser JP, Müller U, Clark L, Sahakian BJ (2007), “The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention.” Int J Neuropsychopharmacol 10(4):449-61 Details

Roiser JP, Rogers RD, Sahakian BJ (2007), “Neuropsychological function in ecstasy users: a study controlling for polydrug use.” Psychopharmacology (Berl) 189(4):505-16 Details

Taylor Tavares JV, Clark L, Cannon DM, Erickson K, Drevets WC, Sahakian BJ (2007), “Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depression.” Biol Psychiatry 62(8):917-24 Details

2006

Barnett JH, Salmond CH, Jones PB, Sahakian BJ (2006), “Cognitive reserve in neuropsychiatry.” Psychol Med 36(8):1053-64 Details

Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2006), “Strategy implementation in obsessive-compulsive disorder and trichotillomania.” Psychol Med 36(1):91-7 Details

Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania.” Am J Psychiatry 163(7):1282-4 Details

Chamberlain SR, Müller U, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Noradrenergic modulation of working memory and emotional memory in humans.” Psychopharmacology (Berl) 188(4):397-407 Details

Chamberlain SR, Müller U, Robbins TW, Sahakian BJ (2006), “Neuropharmacological modulation of cognition.” Curr Opin Neurol 19(6):607-12 Details

Chamberlain SR, Sahakian BJ (2006), “The neuropsychology of mood disorders.” Curr Psychiatry Rep 8(6):458-63 Details

Clark L, Robbins TW, Ersche KD, Sahakian BJ (2006), “Reflection impulsivity in current and former substance users.” Biol Psychiatry 60(5):515-22 Details

Ersche KD, Clark L, London M, Robbins TW, Sahakian BJ (2006), “Profile of executive and memory function associated with amphetamine and opiate dependence.” Neuropsychopharmacology 31(5):1036-47 Details

Ersche KD, Fletcher PC, Roiser JP, Fryer TD, London M, Robbins TW, Sahakian BJ (2006), “Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers.” Psychopharmacology (Berl) 188(3):364-73 Details

Fowler L, Blackwell A, Jaffa A, Palmer R, Robbins TW, Sahakian BJ, Dowson JH (2006), “Profile of neurocognitive impairments associated with female in-patients with anorexia nervosa.” Psychol Med 36(4):517-27 Details

Kaplan JS, Erickson K, Luckenbaugh DA, Weiland-Fiedler P, Geraci M, Sahakian BJ, Charney D, Drevets WC, Neumeister A (2006), “Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder.” J Affect Disord 95(1-3):165-71 Details

Rahman S, Robbins TW, Hodges JR, Mehta MA, Nestor PJ, Clark L, Sahakian BJ (2006), “Methylphenidate ('Ritalin') can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia.” Neuropsychopharmacology 31(3):651-8 Details

Roiser JP, Blackwell AD, Cools R, Clark L, Rubinsztein DC, Robbins TW, Sahakian BJ (2006), “Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion.” Neuropsychopharmacology 31(10):2264-72 Details

Roiser JP, Rogers RD, Cook LJ, Sahakian BJ (2006), “The effect of polymorphism at the serotonin transporter gene on decision-making, memory and executive function in ecstasy users and controls.” Psychopharmacology (Berl) 188(2):213-27 Details

Rubinsztein JS, Michael A, Underwood BR, Tempest M, Sahakian BJ (2006), “Impaired cognition and decision-making in bipolar depression but no 'affective bias' evident.” Psychol Med 36(5):629-39 Details

Salmond CH, DeVito EE, Clark L, Menon DK, Chatfield DA, Pickard JD, Kirkpatrick PJ, Sahakian BJ (2006), “Impulsivity, reward sensitivity, and decision-making in subarachnoid hemorrhage survivors.” J Int Neuropsychol Soc 12(5):697-706 Details

Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ (2006), “Cognitive reserve as a resilience factor against depression after moderate/severe head injury.” J Neurotrauma 23(7):1049-58 Details

Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ (2006), “Changes over time in cognitive and structural profiles of head injury survivors.” Neuropsychologia 44(10):1995-8 Details

Salmond CH, Menon DK, Chatfield DA, Williams GB, Pena A, Sahakian BJ, Pickard JD (2006), “Diffusion tensor imaging in chronic head injury survivors: correlations with learning and memory indices.” Neuroimage 29(1):117-24 Details

Swainson R, SenGupta D, Shetty T, Watkins LH, Summers BA, Sahakian BJ, Polkey CE, Barker RA, Robbins TW (2006), “Impaired dimensional selection but intact use of reward feedback during visual discrimination learning in Parkinson's disease.” Neuropsychologia 44(8):1290-304 Details

2005

Barnett JH, Sahakian BJ, Werners U, Hill KE, Brazil R, Gallagher O, Bullmore ET, Jones PB (2005), “Visuospatial learning and executive function are independently impaired in first-episode psychosis.” Psychol Med 35(7):1031-41 Details

Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2005), “The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers.” Neurosci Biobehav Rev 29(3):399-419 Details

Clark L, Roiser JP, Cools R, Rubinsztein DC, Sahakian BJ, Robbins TW (2005), “Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity.” Psychopharmacology (Berl) 182(4):570-8 Details

De Jager C, Blackwell AD, Budge MM, Sahakian BJ (2005), “Predicting cognitive decline in healthy older adults.” Am J Geriatr Psychiatry 13(8):735-40 Details

Devito EE, Pickard JD, Salmond CH, Iddon JL, Loveday C, Sahakian BJ (2005), “The neuropsychology of normal pressure hydrocephalus (NPH).” Br J Neurosurg 19(3):217-24 Details

Erickson K, Drevets WC, Clark L, Cannon DM, Bain EE, Zarate CA Jr, Charney DS, Sahakian BJ (2005), “Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder.” Am J Psychiatry 162(11):2171-3 Details

Ersche KD, Fletcher PC, Lewis SJ, Clark L, Stocks-Gee G, London M, Deakin JB, Robbins TW, Sahakian BJ (2005), “Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals.” Psychopharmacology (Berl) 180(4):612-23 Details

Ersche KD, Roiser JP, Clark L, London M, Robbins TW, Sahakian BJ (2005), “Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers.” Neuropsychopharmacology 30(11):2115-24 Details

Evers EA, Cools R, Clark L, van der Veen FM, Jolles J, Sahakian BJ, Robbins TW (2005), “Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning.” Neuropsychopharmacology 30(6):1138-47 Details

Galton CJ, Erzinçlioglu S, Sahakian BJ, Antoun N, Hodges JR (2005), “A comparison of the Addenbrooke's Cognitive Examination (ACE), conventional neuropsychological assessment, and simple MRI-based medial temporal lobe evaluation in the early diagnosis of Alzheimer's disease.” Cogn Behav Neurol 18(3):144-50 Details

Keenan S, Mavaddat N, Iddon J, Pickard JD, Sahakian BJ (2005), “Effects of methylphenidate on cognition and apathy in normal pressure hydrocephalus: a case study and review.” Br J Neurosurg 19(1):46-50 Details

Kyte ZA, Goodyer IM, Sahakian BJ (2005), “Selected executive skills in adolescents with recent first episode major depression.” J Child Psychol Psychiatry 46(9):995-1005 Details

Müller U, Clark L, Lam ML, Moore RM, Murphy CL, Richmond NK, Sandhu RS, Wilkins IA, Menon DK, Sahakian BJ, Robbins TW (2005), “Lack of effects of guanfacine on executive and memory functions in healthy male volunteers.” Psychopharmacology (Berl) 182(2):205-13 Details

Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details

Roiser JP, Cook LJ, Cooper JD, Rubinsztein DC, Sahakian BJ (2005), “Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users.” Am J Psychiatry 162(3):609-12 Details

Roiser JP, McLean A, Ogilvie AD, Blackwell AD, Bamber DJ, Goodyer I, Jones PB, Sahakian BJ (2005), “The subjective and cognitive effects of acute phenylalanine and tyrosine depletion in patients recovered from depression.” Neuropsychopharmacology 30(4):775-85 Details

Salmond CH, Chatfield DA, Menon DK, Pickard JD, Sahakian BJ (2005), “Cognitive sequelae of head injury: involvement of basal forebrain and associated structures.” Brain 128(Pt 1):189-200 Details

Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ (2005), “Deficits in decision-making in head injury survivors.” J Neurotrauma 22(6):613-22 Details

Salmond CH, Sahakian BJ (2005), “Cognitive outcome in traumatic brain injury survivors.” Curr Opin Crit Care 11(2):111-6 Details

Tasker RC, Salmond CH, Westland AG, Pena A, Gillard JH, Sahakian BJ, Pickard JD (2005), “Head circumference and brain and hippocampal volume after severe traumatic brain injury in childhood.” Pediatr Res 58(2):302-8 Details

Turner DC, Blackwell AD, Dowson JH, McLean A, Sahakian BJ (2005), “Neurocognitive effects of methylphenidate in adult attention-deficit/hyperactivity disorder.” Psychopharmacology (Berl) 178(2-3):286-95 Details

Watkins LH, Sahakian BJ, Robertson MM, Veale DM, Rogers RD, Pickard KM, Aitken MR, Robbins TW (2005), “Executive function in Tourette's syndrome and obsessive-compulsive disorder.” Psychol Med 35(4):571-82 Details

2004

Aron AR, Monsell S, Sahakian BJ, Robbins TW (2004), “A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex.” Brain 127(Pt 7):1561-73 Details

Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR (2004), “Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease.” Dement Geriatr Cogn Disord 17(1-2):42-8 Details

Chamberlain SR, Sahakian BJ (2004), “Cognition in mania and depression: psychological models and clinical implications.” Curr Psychiatry Rep 6(6):451-8 Details

Deakin J, Aitken M, Robbins T, Sahakian BJ (2004), “Risk taking during decision-making in normal volunteers changes with age.” J Int Neuropsychol Soc 10(4):590-8 Details

Deakin JB, Aitken MR, Dowson JH, Robbins TW, Sahakian BJ (2004), “Diazepam produces disinhibitory cognitive effects in male volunteers.” Psychopharmacology (Berl) 173(1-2):88-97 Details

Deakin JB, Rahman S, Nestor PJ, Hodges JR, Sahakian BJ (2004), “Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial.” Psychopharmacology (Berl) 172(4):400-8 Details

Dowson JH, McLean A, Bazanis E, Toone B, Young S, Robbins TW, Sahakian BJ (2004), “Impaired spatial working memory in adults with attention-deficit/hyperactivity disorder: comparisons with performance in adults with borderline personality disorder and in control subjects.” Acta Psychiatr Scand 110(1):45-54 Details

Elliott R, Ogilvie A, Rubinsztein JS, Calderon G, Dolan RJ, Sahakian BJ (2004), “Abnormal ventral frontal response during performance of an affective go/no go task in patients with mania.” Biol Psychiatry 55(12):1163-70 Details

Ho AK, Nestor PJ, Williams GB, Bradshaw JL, Sahakian BJ, Robbins TW, Barker RA (2004), “Pseudo-neglect in Huntington's disease correlates with decreased angular gyrus density.” Neuroreport 15(6):1061-4 Details

Ho AK, Robbins AO, Walters SJ, Kaptoge S, Sahakian BJ, Barker RA (2004), “Health-related quality of life in Huntington's disease: a comparison of two generic instruments, SF-36 and SIP.” Mov Disord 19(11):1341-8 Details

Ho AK, Sahakian BJ, Robbins TW, Barker RA (2004), “Random number generation in patients with symptomatic and presymptomatic Huntington's disease.” Cogn Behav Neurol 17(4):208-12 Details

Iddon JL, Morgan DJ, Loveday C, Sahakian BJ, Pickard JD (2004), “Neuropsychological profile of young adults with spina bifida with or without hydrocephalus.” J Neurol Neurosurg Psychiatry 75(8):1112-8 Details

McLean A, Dowson J, Toone B, Young S, Bazanis E, Robbins TW, Sahakian BJ (2004), “Characteristic neurocognitive profile associated with adult attention-deficit/hyperactivity disorder.” Psychol Med 34(4):681-92 Details

McLean A, Rubinsztein JS, Robbins TW, Sahakian BJ (2004), “The effects of tyrosine depletion in normal healthy volunteers: implications for unipolar depression.” Psychopharmacology (Berl) 171(3):286-97 Details

Mehta MA, Goodyer IM, Sahakian BJ (2004), “Methylphenidate improves working memory and set-shifting in AD/HD: relationships to baseline memory capacity.” J Child Psychol Psychiatry 45(2):293-305 Details

Mehta MA, Manes FF, Magnolfi G, Sahakian BJ, Robbins TW (2004), “Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers.” Psychopharmacology (Berl) 176(3-4):331-42 Details

Roiser JP, Sahakian BJ (2004), “Relationship between ecstasy use and depression: a study controlling for poly-drug use.” Psychopharmacology (Berl) 173(3-4):411-7 Details

Turner DC, Aitken MR, Shanks DR, Sahakian BJ, Robbins TW, Schwarzbauer C, Fletcher PC (2004), “The role of the lateral frontal cortex in causal associative learning: exploring preventative and super-learning.” Cereb Cortex 14(8):872-80 Details

Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ (2004), “Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder.” Biol Psychiatry 55(10):1031-40 Details

Turner DC, Clark L, Pomarol-Clotet E, McKenna P, Robbins TW, Sahakian BJ (2004), “Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia.” Neuropsychopharmacology 29(7):1363-73 Details

2003

Aron AR, Dowson JH, Sahakian BJ, Robbins TW (2003), “Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder.” Biol Psychiatry 54(12):1465-8 Details

Aron AR, Fletcher PC, Bullmore ET, Sahakian BJ, Robbins TW (2003), “Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans.” Nat Neurosci 6(2):115-6 Details

Aron AR, Sahakian BJ, Robbins TW (2003), “Distractibility during selection-for-action: differential deficits in Huntington's disease and following frontal lobe damage.” Neuropsychologia 41(9):1137-47 Details

Aron AR, Schlaghecken F, Fletcher PC, Bullmore ET, Eimer M, Barker R, Sahakian BJ, Robbins TW (2003), “Inhibition of subliminally primed responses is mediated by the caudate and thalamus: evidence from functional MRI and Huntington's disease.” Brain 126(Pt 3):713-23 Details

Aron AR, Watkins L, Sahakian BJ, Monsell S, Barker RA, Robbins TW (2003), “Task-set switching deficits in early-stage Huntington's disease: implications for basal ganglia function.” J Cogn Neurosci 15(5):629-42 Details

Clark L, Manes F, Antoun N, Sahakian BJ, Robbins TW (2003), “The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage.” Neuropsychologia 41(11):1474-83 Details

Cools R, Barker RA, Sahakian BJ, Robbins TW (2003), “L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease.” Neuropsychologia 41(11):1431-41 Details

Ho AK, Manly T, Nestor PJ, Sahakian BJ, Bak TH, Robbins TW, Rosser AE, Barker RA (2003), “A case of unilateral neglect in Huntington's disease.” Neurocase 9(3):261-73 Details

Ho AK, Sahakian BJ, Brown RG, Barker RA, Hodges JR, Ané MN, Snowden J, Thompson J, Esmonde T, Gentry R, Moore JW, Bodner T, NEST-HD Consortium (2003), “Profile of cognitive progression in early Huntington's disease.” Neurology 61(12):1702-6 Details

Honey RA, Turner DC, Honey GD, Sharar SR, Kumaran D, Pomarol-Clotet E, McKenna P, Sahakian BJ, Robbins TW, Fletcher PC (2003), “Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory.” Neuropsychopharmacology 28(11):2037-44 Details

Iddon JL, Morgan DJ, Ahmed R, Loveday C, Sahakian BJ, Pickard JD (2003), “Memory and learning in young adults with hydrocephalus and spina bifida: specific cognitive profiles.” Eur J Pediatr Surg 13 Suppl 1:S32-5 Details

Lawrence AD, Dowson J, Foxall GL, Summerfield R, Robbins TW, Sahakian BJ (2003), “Impaired visual discrimination learning in anorexia nervosa.” Appetite 40(1):85-9 Details

Lee AC, Rahman S, Hodges JR, Sahakian BJ, Graham KS (2003), “Associative and recognition memory for novel objects in dementia: implications for diagnosis.” Eur J Neurosci 18(6):1660-70 Details

Murphy FC, Michael A, Robbins TW, Sahakian BJ (2003), “Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance.” Psychol Med 33(3):455-67 Details

Pavese N, Andrews TC, Brooks DJ, Ho AK, Rosser AE, Barker RA, Robbins TW, Sahakian BJ, Dunnett SB, Piccini P (2003), “Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study.” Brain 126(Pt 5):1127-35 Details

Rogers RD, Tunbridge EM, Bhagwagar Z, Drevets WC, Sahakian BJ, Carter CS (2003), “Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues.” Neuropsychopharmacology 28(1):153-62 Details

Taylor Tavares JV, Drevets WC, Sahakian BJ (2003), “Cognition in mania and depression.” Psychol Med 33(6):959-67 Details

Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003), “Relative lack of cognitive effects of methylphenidate in elderly male volunteers.” Psychopharmacology (Berl) 168(4):455-64 Details

Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003), “Cognitive enhancing effects of modafinil in healthy volunteers.” Psychopharmacology (Berl) 165(3):260-9 Details

2002

Bazanis E, Rogers RD, Dowson JH, Taylor P, Meux C, Staley C, Nevinson-Andrews D, Taylor C, Robbins TW, Sahakian BJ (2002), “Neurocognitive deficits in decision-making and planning of patients with DSM-III-R borderline personality disorder.” Psychol Med 32(8):1395-405 Details

Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ (2002), “The neural basis of mood-congruent processing biases in depression.” Arch Gen Psychiatry 59(7):597-604 Details

Fox HC, McLean A, Turner JJ, Parrott AC, Rogers R, Sahakian BJ (2002), “Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free MDMA ("ecstasy") polydrug users.” Psychopharmacology (Berl) 162(2):203-14 Details

Ho AK, Sahakian BJ, Robbins TW, Barker RA, Rosser AE, Hodges JR (2002), “Verbal fluency in Huntington's disease: a longitudinal analysis of phonemic and semantic clustering and switching.” Neuropsychologia 40(8):1277-84 Details

Hutton SB, Murphy FC, Joyce EM, Rogers RD, Cuthbert I, Barnes TR, McKenna PJ, Sahakian BJ, Robbins TW (2002), “Decision making deficits in patients with first-episode and chronic schizophrenia.” Schizophr Res 55(3):249-57 Details

Murphy FC, Smith KA, Cowen PJ, Robbins TW, Sahakian BJ (2002), “The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers.” Psychopharmacology (Berl) 163(1):42-53 Details

Rubinsztein JS, Sahakian BJ (2002), “Cognitive impairment in bipolar disorder.” Br J Psychiatry 181:440 Details

Thompson SA, Graham KS, Patterson K, Sahakian BJ, Hodges JR (2002), “Is knowledge of famous people disproportionately impaired in patients with early and questionable Alzheimer's disease?” Neuropsychology 16(3):344-58 Details

Vesey R, Birrell JM, Bolton C, Chipperfield RS, Blackwell AD, Dening TR, Sahakian BJ (2002), “Cholinergic nicotinic systems in Alzheimer's disease: prospects for pharmacological intervention.” CNS Drugs 16(7):485-500 Details

2001

Cools R, Barker RA, Sahakian BJ, Robbins TW (2001), “Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands.” Cereb Cortex 11(12):1136-43 Details

Cools R, Barker RA, Sahakian BJ, Robbins TW (2001), “Mechanisms of cognitive set flexibility in Parkinson's disease.” Brain 124(Pt 12):2503-12 Details

Galton CJ, Gomez-Anson B, Antoun N, Scheltens P, Patterson K, Graves M, Sahakian BJ, Hodges JR (2001), “Temporal lobe rating scale: application to Alzheimer's disease and frontotemporal dementia.” J Neurol Neurosurg Psychiatry 70(2):165-73 Details

Galton CJ, Patterson K, Graham K, Lambon-Ralph MA, Williams G, Antoun N, Sahakian BJ, Hodges JR (2001), “Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia.” Neurology 57(2):216-25 Details

Murphy FC, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES, Sahakian BJ (2001), “Decision-making cognition in mania and depression.” Psychol Med 31(4):679-93 Details

Murphy FC, Sahakian BJ (2001), “Neuropsychology of bipolar disorder.” Br J Psychiatry Suppl 41:s120-7 Details

Murphy FC, Sahakian BJ (2001), “Neuropsychology of bipolar disorder.” Br J Psychiatry 178(Suppl 41):S120-7 Details

Rubinsztein JS, Fletcher PC, Rogers RD, Ho LW, Aigbirhio FI, Paykel ES, Robbins TW, Sahakian BJ (2001), “Decision-making in mania: a PET study.” Brain 124(Pt 12):2550-63 Details

Rubinsztein JS, Rogers RD, Riedel WJ, Mehta MA, Robbins TW, Sahakian BJ (2001), “Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers.” Psychopharmacology (Berl) 154(3):319-26 Details

Swainson R, Hodges JR, Galton CJ, Semple J, Michael A, Dunn BD, Iddon JL, Robbins TW, Sahakian BJ (2001), “Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks.” Dement Geriatr Cogn Disord 12(4):265-80 Details

2000

Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ (2000), “Selective attention to emotional stimuli in a verbal go/no-go task: an fMRI study.” Neuroreport 11(8):1739-44 Details

Lawrence AD, Watkins LH, Sahakian BJ, Hodges JR, Robbins TW (2000), “Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits.” Brain 123 ( Pt 7):1349-64 Details

Mavaddat N, Kirkpatrick PJ, Rogers RD, Sahakian BJ (2000), “Deficits in decision-making in patients with aneurysms of the anterior communicating artery.” Brain 123 ( Pt 10):2109-17 Details

Mehta MA, Calloway P, Sahakian BJ (2000), “Amelioration of specific working memory deficits by methylphenidate in a case of adult attention deficit/hyperactivity disorder.” J Psychopharmacol 14(3):299-302 Details

Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW (2000), “Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain.” J Neurosci 20(6):RC65 Details

Ornstein TJ, Iddon JL, Baldacchino AM, Sahakian BJ, London M, Everitt BJ, Robbins TW (2000), “Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers.” Neuropsychopharmacology 23(2):113-26 Details

Robbins TW, Mehta MA, Sahakian BJ (2000), “Neuroscience. Boosting working memory.” Science 290(5500):2275-6 Details

Rubinsztein JS, Michael A, Paykel ES, Sahakian BJ (2000), “Cognitive impairment in remission in bipolar affective disorder.” Psychol Med 30(5):1025-36 Details

Swainson R, Rogers RD, Sahakian BJ, Summers BA, Polkey CE, Robbins TW (2000), “Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.” Neuropsychologia 38(5):596-612 Details

Watkins LH, Rogers RD, Lawrence AD, Sahakian BJ, Rosser AE, Robbins TW (2000), “Impaired planning but intact decision making in early Huntington's disease: implications for specific fronto-striatal pathology.” Neuropsychologia 38(8):1112-25 Details

Williams D, Stott CM, Goodyer IM, Sahakian BJ (2000), “Specific language impairment with or without hyperactivity: neuropsychological evidence for frontostriatal dysfunction.” Dev Med Child Neurol 42(6):368-75 Details

1999

Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ (1999), “Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study.” J Neurol Neurosurg Psychiatry 67(6):723-32 Details

Lawrence AD, Sahakian BJ, Rogers RD, Hodge JR, Robbins TW (1999), “Discrimination, reversal, and shift learning in Huntington's disease: mechanisms of impaired response selection.” Neuropsychologia 37(12):1359-74 Details

Mavaddat N, Sahakian BJ, Hutchinson PJ, Kirkpatrick PJ (1999), “Cognition following subarachnoid hemorrhage from anterior communicating artery aneurysm: relation to timing of surgery.” J Neurosurg 91(3):402-7 Details

Mehta MA, Sahakian BJ, McKenna PJ, Robbins TW (1999), “Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease.” Psychopharmacology (Berl) 146(2):162-74 Details

Middleton HC, Sharma A, Agouzoul D, Sahakian BJ, Robbins TW (1999), “Idazoxan potentiates rather than antagonizes some of the cognitive effects of clonidine.” Psychopharmacology (Berl) 145(4):401-11 Details

Middleton HC, Sharma A, Agouzoul D, Sahakian BJ, Robbins TW (1999), “Contrasts between the cardiovascular concomitants of tests of planning and attention.” Psychophysiology 36(5):610-8 Details

Murphy FC, Sahakian BJ, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES (1999), “Emotional bias and inhibitory control processes in mania and depression.” Psychol Med 29(6):1307-21 Details

Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SP, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD (1999), “Redefining the functional organization of working memory processes within human lateral prefrontal cortex.” Eur J Neurosci 11(2):567-74 Details

Rahman S, Robbins TW, Sahakian BJ (1999), “Comparative cognitive neuropsychological studies of frontal lobe function: implications for therapeutic strategies in frontal variant frontotemporal dementia.” Dement Geriatr Cogn Disord 10 Suppl 1:15-28 Details

Rahman S, Sahakian BJ, Hodges JR, Rogers RD, Robbins TW (1999), “Specific cognitive deficits in mild frontal variant frontotemporal dementia.” Brain 122 ( Pt 8):1469-93 Details

Rogers RD, Blackshaw AJ, Middleton HC, Matthews K, Hawtin K, Crowley C, Hopwood A, Wallace C, Deakin JF, Sahakian BJ, Robbins TW (1999), “Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour.” Psychopharmacology (Berl) 146(4):482-91 Details

Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K, Baker NB, Hunter J, Carthy T, Booker E, London M, Deakin JF, Sahakian BJ, Robbins TW (1999), “Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms.” Neuropsychopharmacology 20(4):322-39 Details

Rogers RD, Owen AM, Middleton HC, Williams EJ, Pickard JD, Sahakian BJ, Robbins TW (1999), “Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex.” J Neurosci 19(20):9029-38 Details

Young AH, Sahakian BJ, Robbins TW, Cowen PJ (1999), “The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers.” Psychopharmacology (Berl) 145(3):260-6 Details

1998

Elliott R, Sahakian BJ, Michael A, Paykel ES, Dolan RJ (1998), “Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression.” Psychol Med 28(3):559-71 Details

Iddon JL, McKenna PJ, Sahakian BJ, Robbins TW (1998), “Impaired generation and use of strategy in schizophrenia: evidence from visuospatial and verbal tasks.” Psychol Med 28(5):1049-62 Details

Lawrence AD, Hodges JR, Rosser AE, Kershaw A, ffrench-Constant C, Rubinsztein DC, Robbins TW, Sahakian BJ (1998), “Evidence for specific cognitive deficits in preclinical Huntington's disease.” Brain 121 ( Pt 7):1329-41 Details

Lawrence AD, Sahakian BJ (1998), “The cognitive psychopharmacology of Alzheimer's disease: focus on cholinergic systems.” Neurochem Res 23(5):787-94 Details

Lawrence AD, Sahakian BJ, Robbins TW (1998), “Cognitive functions and corticostriatal circuits: insights from Huntington's disease.” Trends Cogn Sci 2(10):379-88 Details

Lawrence AD, Weeks RA, Brooks DJ, Andrews TC, Watkins LH, Harding AE, Robbins TW, Sahakian BJ (1998), “The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease.” Brain 121 ( Pt 7):1343-55 Details

Robbins TW, James M, Owen AM, Sahakian BJ, Lawrence AD, McInnes L, Rabbitt PM (1998), “A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Battery.” J Int Neuropsychol Soc 4(5):474-90 Details

Rogers RD, Sahakian BJ, Hodges JR, Polkey CE, Kennard C, Robbins TW (1998), “Dissociating executive mechanisms of task control following frontal lobe damage and Parkinson's disease.” Brain 121 ( Pt 5):815-42 Details

1997

Elliott R, Baker SC, Rogers RD, O'Leary DA, Paykel ES, Frith CD, Dolan RJ, Sahakian BJ (1997), “Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography.” Psychol Med 27(4):931-42 Details

Elliott R, Sahakian BJ, Herrod JJ, Robbins TW, Paykel ES (1997), “Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment.” J Neurol Neurosurg Psychiatry 63(1):74-82 Details

Elliott R, Sahakian BJ, Matthews K, Bannerjea A, Rimmer J, Robbins TW (1997), “Effects of methylphenidate on spatial working memory and planning in healthy young adults.” Psychopharmacology (Berl) 131(2):196-206 Details

Iddon JL, Sahakian BJ, Kirkpatrick PJ (1997), “Uncomplicated carotid endarterectomy is not associated with neuropsychological impairment.” Pharmacol Biochem Behav 56(4):781-7 Details

1996

Beats BC, Sahakian BJ, Levy R (1996), “Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed.” Psychol Med 26(3):591-603 Details

Coull JT, Sahakian BJ, Hodges JR (1996), “The alpha(2) antagonist idazoxan remediates certain attentional and executive dysfunction in patients with dementia of frontal type.” Psychopharmacology (Berl) 123(3):239-49 Details

Elliott R, Sahakian BJ, McKay AP, Herrod JJ, Robbins TW, Paykel ES (1996), “Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance.” Psychol Med 26(5):975-89 Details

Iddon JL, Morgan DJ, Sahakian BJ (1996), “Cognitive dysfunction in patients with congenital hydrocephalus and spina bifida: evidence for a dysexecutive syndrome?” Eur J Pediatr Surg 6 Suppl 1:41 Details

Lawrence AD, Sahakian BJ, Hodges JR, Rosser AE, Lange KW, Robbins TW (1996), “Executive and mnemonic functions in early Huntington's disease.” Brain 119 ( Pt 5):1633-45 Details

Owen AM, Morris RG, Sahakian BJ, Polkey CE, Robbins TW (1996), “Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man.” Brain 119 ( Pt 5):1597-615 Details

Robbins TW, Elliott R, Sahakian BJ (1996), “Neuropsychology--dementia and affective disorders.” Br Med Bull 52(3):627-43 Details

Veale DM, Sahakian BJ, Owen AM, Marks IM (1996), “Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder.” Psychol Med 26(6):1261-9 Details

1995

Almeida OP, Howard RJ, Levy R, David AS, Morris RG, Sahakian BJ (1995), “Clinical and cognitive diversity of psychotic states arising in late life (late paraphrenia).” Psychol Med 25(4):699-714 Details

Almeida OP, Howard RJ, Levy R, David AS, Morris RG, Sahakian BJ (1995), “Cognitive features of psychotic states arising in late life (late paraphrenia).” Psychol Med 25(4):685-98 Details

Coull JT, Middleton HC, Robbins TW, Sahakian BJ (1995), “Clonidine and diazepam have differential effects on tests of attention and learning.” Psychopharmacology (Berl) 120(3):322-32 Details

Coull JT, Middleton HC, Robbins TW, Sahakian BJ (1995), “Contrasting effects of clonidine and diazepam on tests of working memory and planning.” Psychopharmacology (Berl) 120(3):311-21 Details

Coull JT, Sahakian BJ, Middleton HC, Young AH, Park SB, McShane RH, Cowen PJ, Robbins TW (1995), “Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search.” Psychopharmacology (Berl) 121(2):222-30 Details

Elliott R, McKenna PJ, Robbins TW, Sahakian BJ (1995), “Neuropsychological evidence for frontostriatal dysfunction in schizophrenia.” Psychol Med 25(3):619-30 Details

Elliott R, Sahakian BJ (1995), “The neuropsychology of schizophrenia: relations with clinical and neurobiological dimensions.” Psychol Med 25(3):581-94 Details

Lange KW, Sahakian BJ, Quinn NP, Marsden CD, Robbins TW (1995), “Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia.” J Neurol Neurosurg Psychiatry 58(5):598-606 Details

Lawrence AD, Sahakian BJ (1995), “Alzheimer disease, attention, and the cholinergic system.” Alzheimer Dis Assoc Disord 9 Suppl 2:43-9 Details

Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW (1995), “Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man.” Neuropsychologia 33(1):1-24 Details

Sahakian BJ, Elliott R, Low N, Mehta M, Clark RT, Pozniak AL (1995), “Neuropsychological deficits in tests of executive function in asymptomatic and symptomatic HIV-1 seropositive men.” Psychol Med 25(6):1233-46 Details

1994

Middleton HC, Coull JT, Sahakian BJ, Robbins TW (1994), “Clonidine-induced changes in the spectral distribution of heart rate variability correlate with performance on a test of sustained attention.” J Psychopharmacol 8(1):1-7 Details

Park SB, Coull JT, McShane RH, Young AH, Sahakian BJ, Robbins TW, Cowen PJ (1994), “Tryptophan depletion in normal volunteers produces selective impairments in learning and memory.” Neuropharmacology 33(3-4):575-88 Details

Robbins TW, James M, Owen AM, Sahakian BJ, McInnes L, Rabbitt P (1994), “Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers.” Dementia 5(5):266-81 Details

Sahakian BJ, Coull JJ, Hodges JR (1994), “Selective enhancement of executive function by idazoxan in a patient with dementia of the frontal lobe type.” J Neurol Neurosurg Psychiatry 57(1):120-1 Details

1993

O'Brien JT, Sahakian BJ, Checkley SA (1993), “Cognitive impairments in patients with seasonal affective disorder.” Br J Psychiatry 163:338-43 Details

Owen AM, Beksinska M, James M, Leigh PN, Summers BA, Marsden CD, Quinn NP, Sahakian BJ, Robbins TW (1993), “Visuospatial memory deficits at different stages of Parkinson's disease.” Neuropsychologia 31(7):627-44 Details

Sahakian BJ, Coull JT (1993), “Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB.” Acta Neurol Scand Suppl 149:29-35 Details

Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S, Crayton L, Crockford HA, Crooks M, Hill K, Levy R (1993), “Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB.” Psychopharmacology (Berl) 110(4):395-401 Details

1992

Eagger SA, Levy R, Sahakian BJ (1992), “Tacrine in Alzheimer's disease.” Acta Neurol Scand Suppl 139:75-80 Details

Jones GM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992), “Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease.” Psychopharmacology (Berl) 108(4):485-94 Details

O'Brien JT, Eagger S, Syed GM, Sahakian BJ, Levy R (1992), “A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease.” J Neurol Neurosurg Psychiatry 55(12):1182-7 Details

Sahakian BJ, Owen AM (1992), “Computerized assessment in neuropsychiatry using CANTAB: discussion paper.” J R Soc Med 85(7):399-402 Details

1991

Eagger SA, Levy R, Sahakian BJ (1991), “Tacrine in Alzheimer's disease.” Lancet 338(8758):50-1 Details

Eagger SA, Levy R, Sahakian BJ (1991), “Tacrine in Alzheimer's disease.” Lancet 337(8748):989-92 Details

Orrell MW, Sahakian BJ (1991), “Dementia of frontal lobe type.” Psychol Med 21(3):553-6 Details

Owen AM, Roberts AC, Polkey CE, Sahakian BJ, Robbins TW (1991), “Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man.” Neuropsychologia 29(10):993-1006 Details

1990

Abas MA, Sahakian BJ, Levy R (1990), “Neuropsychological deficits and CT scan changes in elderly depressives.” Psychol Med 20(3):507-20 Details

Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW (1990), “Planning and spatial working memory following frontal lobe lesions in man.” Neuropsychologia 28(10):1021-34 Details

Robbins TW, Giardini V, Jones GH, Reading P, Sahakian BJ (1990), “Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task.” Behav Brain Res 38(3):243-61 Details

Sahakian BJ, Downes JJ, Eagger S, Evenden JL, Levy R, Philpot MP, Roberts AC, Robbins TW (1990), “Sparing of attentional relative to mnemonic function in a subgroup of patients with dementia of the Alzheimer type.” Neuropsychologia 28(11):1197-213 Details

1989

Downes JJ, Roberts AC, Sahakian BJ, Evenden JL, Morris RG, Robbins TW (1989), “Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction.” Neuropsychologia 27(11-12):1329-43 Details

Orrell MW, Sahakian BJ, Bergmann K (1989), “Self-neglect and frontal lobe dysfunction.” Br J Psychiatry 155:101-5 Details

1988

Morris RG, Downes JJ, Sahakian BJ, Evenden JL, Heald A, Robbins TW (1988), “Planning and spatial working memory in Parkinson's disease.” J Neurol Neurosurg Psychiatry 51(6):757-66 Details

Sahakian BJ, Morris RG, Evenden JL, Heald A, Levy R, Philpot M, Robbins TW (1988), “A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease.” Brain 111 ( Pt 3):695-718 Details

1987

Jones GM, Reith M, Philpot MP, Sahakian BJ (1987), “Smoking and dementia of Alzheimer type.” J Neurol Neurosurg Psychiatry 50(10):1383 Details

Levy R, Sahakian BJ (1987), “Sub-cortical dementia.” Br J Psychiatry 150:559-60 Details

1986

Hutson PH, Sarna GS, Sahakian BJ, Dourish CT, Curzon G (1986), “Monitoring 5HT metabolism in the brain of the freely moving rat.” Ann N Y Acad Sci 473:321-36 Details

Sahakian BJ, Sarna GS, Kantamaneni DB, Jackson A, Hutson PH, Curzon G (1986), “CSF tryptophan and transmitter amine turnover may predict social behaviour in the normal rat.” Brain Res 399(1):162-6 Details

1985

Curzon G, Hutson PH, Kantamaneni BD, Sahakian BJ, Sarna GS (1985), “3,4-Dihydroxyphenylethylamine and 5-hydroxytryptamine metabolism in the rat: acidic metabolites in cisternal cerebrospinal fluid before and after giving probenecid.” J Neurochem 45(2):508-13 Details

Sahakian BJ, Sarna GS, Kantamaneni BD, Jackson A, Hutson PH, Curzon G (1985), “Association between learning and cortical catecholamines in non-drug-treated rats.” Psychopharmacology (Berl) 86(3):339-43 Details

1983

Keymer A, Crompton DW, Sahakian BJ (1983), “Parasite-induced learned taste aversion involving Nippostrongylus in rats.” Parasitology 86 (Pt 3):455-60 Details

Sahakian BJ, Trayhurn P, Wallace M, Deeley R, Winn P, Robbins TW, Everitt BJ (1983), “Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline.” Neurosci Lett 39(3):321-6 Details

Sahakian BJ, Winn P, Robbins TW, Deeley RJ, Everitt BJ, Dunn LT, Wallace M, James WP (1983), “Changes in body weight and food-related behaviour induced by destruction of the ventral or dorsal noradrenergic bundle in the rat.” Neuroscience 10(4):1405-20 Details

1982

Dyme IZ, Sahakian BJ, Golinko BE, Rabe EF (1982), “Perseveration induced by methylphenidate in children: preliminary findings.” Prog Neuropsychopharmacol Biol Psychiatry 6(3):269-73 Details

Sahakian BJ (1982), “The interaction of psychological and metabolic factors in the control of eating and obesity.” Hum Nutr Appl Nutr 36A(4):262-71 Details

Sahakian BJ (1982), “The interaction of psychological and metabolic factors in the control of eating and obesity.” Scand J Psychol Suppl 1:48-60 Details

Sahakian BJ, Burdess C, Luckhurst H, Trayhurn P (1982), “Hyperactivity and obesity: the interaction of social isolation and cafeteria feeding.” Physiol Behav 28(1):117-24 Details

1981

James WP, Sahakian BJ (1981), “Overgrowth: energetic significance in relation to obesity.” Prog Clin Biol Res 61:25-53 Details

Sahakian BJ, Lean ME, Robbins TW, James WP (1981), “Salivation and insulin secretion in response to food in non-obese men and women.” Appetite 2(3):209-16 Details

1980

Drachman DA, Noffsinger D, Sahakian BJ, Kurdziel S, Fleming P (1980), “Aging, memory, and the cholinergic system: a study of dichotic listening.” Neurobiol Aging 1(1):39-43 Details

Drachman DA, Sahakian BJ (1980), “Memory and cognitive function in the elderly. A preliminary trial of physostigmine.” Arch Neurol 37(10):674-5 Details

Fray PJ, Sahakian BJ, Robbins TW, Koob GF, Iversen SD (1980), “An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine.” Psychopharmacology (Berl) 69(3):253-9 Details

Hefti F, Melamed E, Sahakian BJ, Wurtman RJ (1980), “Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and DOPA.” Pharmacol Biochem Behav 12(2):185-8 Details

Sahakian BJ, Carlson KR, DeGirolami U, Bhawan J (1980), “Functional and structural consequences of long-term dietary L-dopa treatment in mice.” Commun Psychopharmacol 4(2):169-76 Details

1979

Drachman DA, Sahakian BJ, Fleming P, Noffsinger D, Kurdziel S (1979), “Aging, memory, and the cholinergic system: a study of dichotic listening.” Trans Am Neurol Assoc 104:165-8 Details

Einon DF, Sahakian BJ (1979), “Environmentally induced differences in susceptibility of rats to CNS stimulants and CNS depressants: evidence against a unitary explanation.” Psychopharmacology (Berl) 61(3):299-307 Details

Robbins TW, Sahakian BJ (1979), “"Paradoxical" effects of psychomotor stimulant drugs in hyperactive children from the standpoint of behavioural pharmacology.” Neuropharmacology 18(12):931-50 Details

Sahakian BJ, Wurtman RJ, Barr JK, Millington WR, Chiel HJ (1979), “Low tryptophan diet decreases brain serotonin and alters response to apomorphine.” Nature 279(5715):731-2 Details

1978

Sahakian BJ, Growdon JH, Millington WR, Barr JK, Wurtman RJ (1978), “The effects of cholinergic agonists on apomorphine-induced stereotyped behavior in the rat.” Commun Psychopharmacol 2(3):255-62 Details

Sahakian BJ, Koob GF (1978), “The relationship between pipradrol-induced responding for electrical brain stimulation, stereotyped behaviour and locomotor activity.” Neuropharmacology 17(6):363-6 Details

1977

Robbins TW, Phillips AG, Sahakian BJ (1977), “Effects of chlordiazepoxide on tail pinch-induced eating in rats.” Pharmacol Biochem Behav 6(3):297-302 Details

Sahakian BJ, Robbins TW (1977), “Are the effects of psychomotor stimulant drugs on hyperactive children really paradoxical?” Med Hypotheses 3(4):154-8 Details

Sahakian BJ, Robbins TW (1977), “Isolation-rearing enhances tail pinch-induced oral behavior in rats.” Physiol Behav 18(1):53-8 Details

1976

Oscar-Berman M, Sahakian BJ (1976), “Spatial probability learning by alcoholic Korsakoff patients.” J Exp Psychol Hum Learn 2(2):215-22 Details

Sahakian BJ, Robbins TW, Iversen SD (1976), “Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.” Eur J Pharmacol 37(1):169-78 Details

1975

Einon D, Morgan MJ, Sahakian BJ (1975), “The development of intersession habituation and emergence in socially reared and isolated rats.” Dev Psychobiol 8(6):553-9 Details

Sahakian BJ, Robbins TW (1975), “Potentiation of locomotor activity and modification of sterotypy by starvation in adomorphine treated rats.” Neuropharmacology 14(4):251-7 Details

Sahakian BJ, Robbins TW, Morgan MJ, Iversen SD (1975), “The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats.” Brain Res 84(2):195-205 Details

1972

Sahakian WS, Sahakian BJ (1972), “Logotherapy as a personaltiy theory.” Isr Ann Psychiatr Relat Discip 10(3):230-44 Details