Dr Alessio Vagnoni
NC3Rs David Sainsbury Fellow
http://www2.mrc-lmb.cam.ac.uk/groups/... (personal home page)
The main goal of my research is to better understand the mechanisms of neuronal ageing in vivo. I am particularly interested in studying how macromolecules, proteins and organelles are trafficked within neuronal axons and how this process is regulated over the lifetime of an organism, in health and disease states.
I am using the fruit fly Drosophila melanogaster and murine models to study how axonal transport is regulated in space and time in the peripheral nervous system of these animals. By combining in vivo imaging studies in whole organisms with the use of neuronal cultures, my aim is to discover evolutionary conserved regulatory nodes of axonal transport in ageing neurons.
The knowledge gained from studying the mechanisms that underlie neuronal ageing will have significant implications for our understanding of age-dependent neurological disorders.
Cross-sectional and cohort studies
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