Dr John Apergis-Schoute

University position

Senior Research Associate

Dr John Apergis-Schoute is pleased to consider applications from prospective PhD students.

Departments

Department of Pharmacology

Email

ja451@cam.ac.uk

Research Themes

Systems and Computational Neuroscience

Cognitive and Behavioural Neuroscience

Interests

The psychological link between appetite and emotions is clear. Often enough food consumption is powerfully influenced by emotional cues that are unrelated to energy requirements. As the amygdala and hypothalamus, two neural regions that code for appetite and emotions, respectively, are anatomically connected it is probable that this link may reside in the functional connectivity between the two. The impact however that hypothalamic and amygdala circuits have on one another is currently unclear. Using advanced electrophysiological, genetic and behavioural techniques, my research aims to understand the functional impact between specific amygdala and hypothalamic circuits. By combining electrophysiological data regarding the functional connectivity of neurochemically-defined circuits with behaviour aimed at manipulating those circuits our hope is to shed light on the neural interactions that underlie our emotional drive to eat.

Research Focus

Keywords

electrophysiology

feeding

amygdala

hypothalamus

optogenetics

Clinical conditions

Anxiety disorders

Eating disorders

Stress

Equipment

Behavioural analysis

Confocal microscopy

Field potential recording

Immunohistochemistry

Intracellular recording

optogenetics

Whole cell patch clamp

Collaborators

Cambridge

Denis Burdakov

Ole Paulsen

Associated News Items


Publications

2015

Apergis-Schoute J, Iordanidou P, Faure C, Jego S, Schöne C, Aitta-Aho T, Adamantidis A, Burdakov D (2015), “Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits.” J Neurosci 35(14):5435-41 Details

2014

Schöne C, Apergis-Schoute J, Sakurai T, Adamantidis A, Burdakov D (2014), “Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons.” Cell Rep 7(3):697-704 Details

Shipton OA, El-Gaby M, Apergis-Schoute J, Deisseroth K, Bannerman DM, Paulsen O, Kohl MM (2014), “Left-right dissociation of hippocampal memory processes in mice.” Proc Natl Acad Sci U S A 111(42):15238-43 Details

2012

Schöne C, Cao ZF, Apergis-Schoute J, Adamantidis A, Sakurai T, Burdakov D (2012), “Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ.” J Neurosci 32(36):12437-43 Details

Unal G, Apergis-Schoute J, Paré D (2012), “Associative properties of the perirhinal network.” Cereb Cortex 22(6):1318-32 Details

2011

Karnani MM, Apergis-Schoute J, Adamantidis A, Jensen LT, de Lecea L, Fugger L, Burdakov D (2011), “Activation of central orexin/hypocretin neurons by dietary amino acids.” Neuron 72(4):616-29 Details

2010

Saleem AB, Chadderton P, Apergis-Schoute J, Harris KD, Schultz SR (2010), “Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentials.” J Comput Neurosci 29(1-2):49-62 Details

2008

Likhtik E, Popa D, Apergis-Schoute J, Fidacaro GA, Paré D (2008), “Amygdala intercalated neurons are required for expression of fear extinction.” Nature 454(7204):642-5 Details

2007

Apergis-Schoute J, Pinto A, Paré D (2007), “Muscarinic control of long-range GABAergic inhibition within the rhinal cortices.” J Neurosci 27(15):4061-71 Details

2006

Apergis-Schoute J, Pinto A, Paré D (2006), “Ultrastructural organization of medial prefrontal inputs to the rhinal cortices.” Eur J Neurosci 24(1):135-44 Details

2005

Pelletier JG, Apergis-Schoute J, Paré D (2005), “Interaction between amygdala and neocortical inputs in the perirhinal cortex.” J Neurophysiol 94(3):1837-48 Details

2004

Pelletier JG, Apergis J, Paré D (2004), “Low-probability transmission of neocortical and entorhinal impulses through the perirhinal cortex.” J Neurophysiol 91(5):2079-89 Details

Sullivan GM, Apergis J, Bush DE, Johnson LR, Hou M, Ledoux JE (2004), “Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulus.” Neuroscience 128(1):7-14 Details

2003

Sullivan GM, Apergis J, Gorman JM, LeDoux JE (2003), “Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala.” Biol Psychiatry 53(10):863-70 Details

2001

Repa JC, Muller J, Apergis J, Desrochers TM, Zhou Y, LeDoux JE (2001), “Two different lateral amygdala cell populations contribute to the initiation and storage of memory.” Nat Neurosci 4(7):724-31 Details