Dr John Apergis-Schoute
University position
Senior Research Associate
Dr John Apergis-Schoute is pleased to consider applications from prospective PhD students.
Departments
Research Themes
Interests
The psychological link between appetite and emotions is clear. Often enough food consumption is powerfully influenced by emotional cues that are unrelated to energy requirements. As the amygdala and hypothalamus, two neural regions that code for appetite and emotions, respectively, are anatomically connected it is probable that this link may reside in the functional connectivity between the two. The impact however that hypothalamic and amygdala circuits have on one another is currently unclear. Using advanced electrophysiological, genetic and behavioural techniques, my research aims to understand the functional impact between specific amygdala and hypothalamic circuits. By combining electrophysiological data regarding the functional connectivity of neurochemically-defined circuits with behaviour aimed at manipulating those circuits our hope is to shed light on the neural interactions that underlie our emotional drive to eat.
Research Focus
Keywordselectrophysiology feeding amygdala hypothalamus optogenetics |
Clinical conditionsAnxiety disorders Eating disorders Stress |
Equipment
Behavioural analysis
Confocal microscopy
Field potential recording
Immunohistochemistry
Intracellular recording
optogenetics
Whole cell patch clamp
Collaborators
Cambridge |
Publications
2012
Unal G, Apergis-Schoute J, Paré D (2012), “Associative properties of the perirhinal network.” Cereb Cortex 22(6):1318-32 Details
2011
Karnani MM, Apergis-Schoute J, Adamantidis A, Jensen LT, de Lecea L, Fugger L, Burdakov D (2011), “Activation of central orexin/hypocretin neurons by dietary amino acids.” Neuron 72(4):616-29 Details
2010
Saleem AB, Chadderton P, Apergis-Schoute J, Harris KD, Schultz SR (2010), “Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentials.” J Comput Neurosci 29(1-2):49-62 Details
2008
Likhtik E, Popa D, Apergis-Schoute J, Fidacaro GA, Paré D (2008), “Amygdala intercalated neurons are required for expression of fear extinction.” Nature 454(7204):642-5 Details
2007
Apergis-Schoute J, Pinto A, Paré D (2007), “Muscarinic control of long-range GABAergic inhibition within the rhinal cortices.” J Neurosci 27(15):4061-71 Details
2006
Apergis-Schoute J, Pinto A, Paré D (2006), “Ultrastructural organization of medial prefrontal inputs to the rhinal cortices.” Eur J Neurosci 24(1):135-44 Details
2005
Pelletier JG, Apergis-Schoute J, Paré D (2005), “Interaction between amygdala and neocortical inputs in the perirhinal cortex.” J Neurophysiol 94(3):1837-48 Details
2004
Pelletier JG, Apergis J, Paré D (2004), “Low-probability transmission of neocortical and entorhinal impulses through the perirhinal cortex.” J Neurophysiol 91(5):2079-89 Details
Sullivan GM, Apergis J, Bush DE, Johnson LR, Hou M, Ledoux JE (2004), “Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulus.” Neuroscience 128(1):7-14 Details
2003
Sullivan GM, Apergis J, Gorman JM, LeDoux JE (2003), “Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala.” Biol Psychiatry 53(10):863-70 Details
2001
Repa JC, Muller J, Apergis J, Desrochers TM, Zhou Y, LeDoux JE (2001), “Two different lateral amygdala cell populations contribute to the initiation and storage of memory.” Nat Neurosci 4(7):724-31 Details
Research and Collaboration
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