Dr Tony Coll
University position
Lecturer
Dr Tony Coll is pleased to consider applications from prospective PhD students.
Departments
Department of Clinical Biochemistry
Institutes
Institute of Metabolic Science
Home page
Research Themes
Interests
My current research continues to focus upon the roles of the hypothalamus in the control of energy balance. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to utilise the power of both murine genetics and whole animal physiological studies to address these issues. I aim to model disease-related mutations in murine systems and continue the powerful, synergistic relationship between human genetics and murine modelling which has been so fruitful in understanding complex systems biology.
Research Focus
Keywordsappetite leptin melanocortin hypothalamus |
Clinical conditionsDiabetes Hormonal disorders Obesity |
Equipment
No equipment indicated
Collaborators
Cambridge |
Key publications
Coll AP, Farooqi IS, O'Rahilly S (2007), “The hormonal control of food intake” Cell 129(2):251-62 Details
Tung YC, Piper SJ, Yeung D, O'Rahilly S, Coll AP (2006), “A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice” Endocrinology 147(12):5940-7 Details
Coll AP, Challis BG, Lopez M, Piper S, Yeo GS, O'Rahilly (2005), “S.Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids” Diabetes 54(8):2269-76 Details
Publications
2010
Corander MP, Challis BG, Thompson EL, Jovanovic Z, Loraine Tung YC, Rimmington D, Huhtaniemi IT, Murphy KG, Topaloglu AK, Yeo GS, O'Rahilly S, Dhillo WS, Semple RK, Coll AP (2010), “The effects of neurokinin B upon gonadotrophin release in male rodents.” J Neuroendocrinol 22(3):181-7 Details
Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GS (2010), “Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.” PLoS One 5(1):e8771 Details
2009
Corander MP, Fenech M, Coll AP (2009), “Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage.” Circulation 120(22):2260-8 Details
2008
Coll AP, Yeo GS, Farooqi IS, O'Rahilly S (2008), “SnapShot: the hormonal control of food intake.” Cell 135(3):572.e1-2 Details
Prieur X, Tung YC, Griffin JL, Farooqi IS, O'Rahilly S, Coll AP (2008), “Leptin regulates peripheral lipid metabolism primarily through central effects on food intake.” Endocrinology 149(11):5432-9 Details
2007
Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ (2007), “The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.” Science 318(5855):1469-72 Details
Tung YC, Rimmington D, O'Rahilly S, Coll AP (2007), “Pro-opiomelanocortin modulates the thermogenic and physical activity responses to high-fat feeding and markedly influences dietary fat preference.” Endocrinology 148(11):5331-8 Details
Research and Collaboration
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