Alisa Molotova MSci, MRes

University position

PhD student
Supervised by Robin Franklin / Kevin Chalut

Departments

Department of Clinical Neurosciences

Institutes

Wellcome Trust Centre for Stem Cell Research

Home page

http://molotoffblog.wordpress.com (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Developmental Neuroscience

Interests

The tissue extracellular matrix (ECM) provides the resident progenitor cells with both biochemical and physical cues, which regulate stem cell fate. During ageing the brain ECM is dynamically altered leading to an imbalance in the tissue homeostasis, which has been linked to a decrease in remyelination efficiency. Chronically demyelinated axons are susceptible to atrophy leading to age-related neurodegeneration and eventual decline in several cognitive functions. In the CNS remyelination is carried out by oligodendrocytes produced from a population of stem/progenitor cells called oligodendrocyte progenitor cells (OPCs). While OPC numbers remain constant into old age, this cell type portrays a significantly reduced regeneration efficiency. In my PhD project, I aim to identify the ECM components, which contribute to the changes in brain mechanics with ageing as well as identify the molecular circuitry behind the reduced OPC regenerative capacity in response to external triggers.

Research Focus

Keywords

mechanosensing

OPC

myelination

regeneration

rejuvenation

Clinical conditions

Cognitive impairment

Equipment

No equipment indicated

Collaborators

No collaborators listed

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