Dr Amy Milton

Amy Milton

University position

Lecturer

Dr Amy Milton is pleased to consider applications from prospective PhD students.

Departments

Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Home page

http://www.psychol.cam.ac.uk

Research Themes

Cognitive and Behavioural Neuroscience

Cellular and Molecular Neuroscience

Interests

Memory is a critical function of the brain, but little is known about the mechanisms by which memories are modified, adapted, and persist. Memories are known to 'reconsolidate' undergoing updating and strengthening following their destabilisation at retrieval. I study the neurochemical, molecular and intracellular basis of the reconsolidation process, for aversive (fear) and appetitive (addictive drug) memories. Using translationally relevant animal models of neuropsychiatric disorders, such as post-traumatic stress disorder and drug addiction, I also focus on using this knowledge of memory reconsolidation mechanisms to develop treatments for these disorders, based on the disruption of maladaptive memories.

Research Focus

Keywords

memory reconsolidation

addiction

post-traumatic stress disorder

glutamate

adrenaline

Clinical conditions

Addiction

Amnesia

Anxiety disorders

Post-traumatic stress disorder

Equipment

Behavioural analysis

Collaborators

Cambridge

Barry Everitt

Zara Goozée

Emiliano Merlo

Mark Renshaw

George Vousden

United Kingdom

Jonathan Lee

Key publications

Milton AL, Merlo E, Ratano P, Gregory BL, Dumbreck JK, Everitt BJ (2013), “Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.” J Neurosci 33(3):1109-15 Details

Milton AL, Everitt BJ (2012), “The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments.” Neurosci Biobehav Rev 36(4):1119-39 Details

Milton AL, Everitt BJ (2010), “The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction.” Eur J Neurosci 31(12):2308-19 Details

Publications

2014

Merlo E, Milton AL, Goozée ZY, Theobald DE, Everitt BJ (2014), “Reconsolidation and extinction are dissociable and mutually exclusive processes: behavioral and molecular evidence.” J Neurosci 34(7):2422-31 Details

Ratano P, Everitt BJ, Milton AL (2014), “The CB1 Receptor Antagonist AM251 Impairs Reconsolidation of Pavlovian Fear Memory in the Rat Basolateral Amygdala.” Neuropsychopharmacology Details

2013

Corlett PR, Cambridge V, Gardner JM, Piggot JS, Turner DC, Everitt JC, Arana FS, Morgan HL, Milton AL, Lee JL, Aitken MR, Dickinson A, Everitt BJ, Absalom AR, Adapa R, Subramanian N, Taylor JR, Krystal JH, Fletcher PC (2013), “Ketamine effects on memory reconsolidation favor a learning model of delusions.” PLoS One 8(6):e65088 Details

Fernando AB, Murray JE, Milton AL (2013), “The amygdala: securing pleasure and avoiding pain.” Front Behav Neurosci 7:190 Details

Milton AL (2013), “Drink, drugs and disruption: memory manipulation for the treatment of addiction.” Curr Opin Neurobiol 23(4):706-12 Details

2012

Milton AL, Everitt BJ (2012), “Neuroscience. Wiping drug memories.” Science 336(6078):167-8 Details

Milton AL, Schramm MJ, Wawrzynski JR, Gore F, Oikonomou-Mpegeti F, Wang NQ, Samuel D, Economidou D, Everitt BJ (2012), “Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli.” Psychopharmacology (Berl) 219(3):751-61 Details

2010

Théberge FR, Milton AL, Belin D, Lee JL, Everitt BJ (2010), “The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation.” Learn Mem 17(9):444-53 Details

2008

Milton AL, Lee JL, Butler VJ, Gardner R, Everitt BJ (2008), “Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviors.” J Neurosci 28(33):8230-7 Details

Milton AL, Lee JLC, Everitt BJ (2008), “Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on b-adrenergic receptors” Learning & Memory 15:88-92

2006

Lee JLC, Milton AL, Everitt BJ (2006), “Reconsolidation and extinction of conditioned fear: inhibition and potentiation” The Journal of Neuroscience 26:10051-10056

Lee JLC, Milton AL, Everitt BJ (2006), “Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation” The Journal of Neuroscience 26:5881-5887

2004

Milton AL, Marshall JW, Cummings RM, Baker HF, Ridley RM (2004), “Dissociation of hemi-spatial and hemi-motor impairments in a unilateral primate model of Parkinson's disease.” Behav Brain Res 150(1-2):55-63 Details