Andrea Loreto


University position

Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

al850@cam.ac.uk

Home page

http://www.brc.cam.ac.uk/

Research Theme

Cellular and Molecular Neuroscience

Interests

Axon degeneration is an early feature of several neurodegenerative diseases, including Parkinson's disease, motor neuron disease, multiple sclerosis and Glaucoma.

My primary area of research focuses on understanding the molecular mechanisms leading to axon degeneration after injury and mitochondrial dysfunction. We aim to identify regulators of axon death and eventually study their involvement in the development of neurodegenerative disorders.

Research Focus

Keywords

Axon degeneration

Wallerian degeneration

NMNAT2

Axonal transport

Mitochondrial dysfunction

Clinical conditions

Alzheimer's disease

Amyotrophic lateral sclerosis

Dementia

Diabetes

Huntington's disease

Multiple sclerosis

Parkinson's disease

Traumatic brain injury

Equipment

Calcium imaging

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Live imaging

Microscopy

Molecular biology

Recombinant protein expression

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Di Stefano M, Loreto A, Orsomando G, Mori V, Zamporlini F, Hulse RP, Webster J, Donaldson LF, Gering M, Raffaelli N, Coleman MP, Gilley J, Conforti L (2017), “NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo” Curr Biol 27(6):784-794

    Loreto A, Di Stefano M, Gering M, Conforti L (2015), “Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria” Cell Rep 13(11):2539-52

    Publications

    2014

    Di Stefano M, Nascimento-Ferreira I, Orsomando G, Mori V, Gilley J, Brown R, Janeckova L, Vargas ME, Worrell LA, Loreto A, Tickle J, Patrick J, Webster JR, Marangoni M, Carpi FM, Pucciarelli S, Rossi F, Meng W, Sagasti A, Ribchester RR, Magni G, Coleman MP, Conforti L (2014), “A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration” Cell Death Differ 22(5):731-42

    2012

    Di Pasquale G, Dicembrini I, Raimondi L, Pagano C, Egan JM, Cozzi A, Cinci L, Loreto A, Manni ME, Berretti S, Morelli A, Zheng C, Michael DG, Maggi M, Vettor R, Chiorini JA, Mannucci E, Rotella CM (2012), “Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes” PLoS One 7(7):e40074