Dr Alexis Joannides
University position
Research Associate
Departments
Department of Clinical Neurosciences
Institutes
Cambridge Centre for Brain Repair
Research Themes
Interests
We have established a scaleable and clinically compatible system for generating and propagating neural stem cells from human embryonic stem (ES) cells. Using this platform, and building on our work on mouse ES cells demonstrating a correlation of developmental restriction with the onset of gliogenesis, we are investigating the interplay between extrinsic signals and intrinsic determinants on developmental plasticity in a human context.
Research Focus
Keywordsstem cells developmental plasticity |
Clinical conditionsAlzheimer's disease Huntington's disease Multiple sclerosis Parkinson's disease |
Equipment
Cell culture
Confocal microscopy
Electrophysiological recording techniques
Fluorescence microscopy
Immunohistochemistry
Microscopy
Collaborators
No collaborators listed
Key publications
Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine K, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S (2007), “Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells” Brain 130:1263-1275 Details
Bouhon IA, Joannides A, Kato H, Chandran S, Allen ND (2006), “Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning” Stem Cells 24:1908-1913 Details
Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S (2004), “Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells” Lancet 362:172-178 Details
Research and Collaboration
News, events and seminars
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