My research is focused on the process of demyelination and remyelination in the central nervous system and their relationship with Multiple Sclerosis. Remyelination is one of the most important processes in the CNS, in order to maintain the axon transport and to avoid neuronal loss, thanks to its protective effect.
From this poin of view, it is important to study the expression of different proteins involved in the maturation of the cells, which take part in the remyleination process, like Oligodendrocyt Precursor Cells.
Because of this reason, my PhD project will focus on studying the expression of different proteins in OPC, which can be involved in regulating the differentiation and remyelination in the CNS.
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Associated News Items
Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente AG, Pelucchi S, Di Marino D, Borroni B, Tramontano A, Pérez-Otaño I, Padovani A, Giustetto M, Gardoni F, Di Luca M (2013), “Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.” J Clin Invest 123(6):2523-38 Details
Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C (2010), “Masking of transmembrane-based retention signals controls ER export of gamma-secretase.” Traffic 11(2):250-8 Details