Alerie Guzman

University position

PhD student
Supervised by Prof. Robin Franklin

Departments

Department of Clinical Neurosciences

Institutes

Wellcome Trust Centre for Stem Cell Research

Email

ag636@cam.ac.uk

Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience

Interests

My research is focused on the process of demyelination and remyelination in the central nervous system and their relationship with Multiple Sclerosis. Remyelination is one of the most important processes in the CNS, in order to maintain the axon transport and to avoid neuronal loss, thanks to its protective effect.

From this poin of view, it is important to study the expression of different proteins involved in the maturation of the cells, which take part in the remyleination process, like Oligodendrocyt Precursor Cells.

Because of this reason, my PhD project will focus on studying the expression of different proteins in OPC, which can be involved in regulating the differentiation and remyelination in the CNS.

Research Focus

Keywords

CNS

Remyelination

OPC

Oligondendrocyte

Multiple Sclerosis

Clinical conditions

Addiction

Autoimmune diseases

Cancers

Multiple sclerosis

Parkinson's disease

Equipment

Cell culture

Fluorescence microscopy

Immunohistochemistry

Protein purification

Collaborators

No collaborators listed

Associated News Items


    Publications

    2013

    Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente AG, Pelucchi S, Di Marino D, Borroni B, Tramontano A, Pérez-Otaño I, Padovani A, Giustetto M, Gardoni F, Di Luca M (2013), “Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.” J Clin Invest 123(6):2523-38 Details

    2010

    Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C (2010), “Masking of transmembrane-based retention signals controls ER export of gamma-secretase.” Traffic 11(2):250-8 Details