Professor Anne Ferguson-Smith

Anne Ferguson-Smith

University position

Head of Department

Professor Anne Ferguson-Smith is pleased to consider applications from prospective PhD students.

Departments

Department of Genetics

Email

afsmith@mole.bio.cam.ac.uk

Home page

http://www.pdn.cam.ac.uk/staff/f...

Research Theme

Developmental Neuroscience

Interests

Genomic imprinting is an epigenetic mechanism causing genes to be expressed depending on their parental origin. Our research investigates the mechanism and evolution of genomic imprinting and the function of imprinted genes in development and disease. Part of this programme considers the implications of epigenetic control in the development and function of the brain. We also use imprinting as a model system for analysing the epigenetic control of genome function and in particular the roles of DNA methylation and histone modifications in the regulation of gene activity and repression. Our work focuses on an imprinted domain that includes genes and non-coding RNAs that are expressed during neural development and in the adult brain. Little is known about the precise roles of these genes. We are taking molecular approaches using mouse genetic models to address the function of these genes.

Research Focus

Keywords

epigenetics

genomic imprinting

non-coding RNA

methylation

stem cells and development

Clinical conditions

Genetic disorders

Equipment

Cell culture

develomental neurogenetics

Enzyme assays

epigenetic analysis

gene targeting - knockout mice

Immunohistochemistry

mouse molecular genetics

transgenic mice

Collaborators

No collaborators listed