Professor Adrian Owen

Adrian Owen

University position

Senior Scientist/Assistant Director

Institutes

MRC Cognition and Brain Sciences Unit

Email

uwocerc@uwo.ca

Home page

http://adrianowen.org (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Clinical and Veterinary Neuroscience

Interests

In January 2011, my research team and I moved to the University of Western Ontario, Canada, where I have taken up the Canada Excellence Research Chair (CERC) in Cognitive Neuroscience and Imaging. Although I continue to maintain strong collaborative links with many former colleagues at Cambridge, I am no longer responding to email sent to my Cambridge address or to applications to work with me in Cambridge. For alternative options and updated details about my current research, please visit my personal website at http://adrianowen.org

Communication in the vegetative state (Owen et al., Science, 2006; Monti et al., NEJM, 2010 )
Communication in the vegetative state (Owen et al., Science, 2006; Monti et al., NEJM, 2010 )
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Research Focus

Keywords

fMRI

consciousness

frontal lobe

Parkinson's disease

imaging

Clinical conditions

Alzheimer's disease

Cognitive impairment

Dementia

Huntington's disease

Locked-in syndrome

Minimally conscious state

Movement disorders

Obsessive compulsive disorder

Parkinson's disease

Progressive supranuclear palsy

Traumatic brain injury

Vegetative state

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Magnetoencephalography (MEG)

Neuropsychological testing

Positron Emission Tomography (PET)

Transcranial magnetic stimulation (TMS)

Collaborators

Cambridge

Roger Barker

Trevor Robbins

Angela Roberts

Caroline Williams-Gray

United Kingdom

John Parkinson Web: http://www.psychology.bangor.ac.uk/~john_p...

Key publications

Monti MM, Vanhaudenhuyse A, Coleman MR, Boly M, Pickard JD, Tshibanda L, Owen AM, Laureys S (2010), “Willful modulation of brain activity in disorders of consciousness.” N Engl J Med 362(7):579-89 Details

Owen AM, Hampshire A, Grahn JA, Stenton R, Dajani S, Burns AS, Howard RJ, Ballard CG (2010), “Putting brain training to the test.” Nature 465(7299):775-8 Details

Hampshire A, Owen AM (2006), “Fractionating attentional control using event related fMRI” Cerebral Cortex 16(12):1679-1689 Details

Owen AM, Coleman MR, Davis MH, Boly M, Laureys S, Pickard JD (2006), “Detecting awareness in the vegetative state” Science 313:1402 Details

Publications

2012

Cruse D, Chennu S, Chatelle C, Fernández-Espejo D, Bekinschtein TA, Pickard JD, Laureys S, Owen AM (2012), “Relationship between etiology and covert cognition in the minimally conscious state.” Neurology 78(11):816-22 Details

Fallon SJ, Williams-Gray CH, Barker RA, Owen AM, Hampshire A (2012), “Prefrontal Dopamine Levels Determine the Balance between Cognitive Stability and Flexibility.” Cereb Cortex Details

Hampshire A, Chaudhry AM, Owen AM, Roberts AC (2012), “Dissociable roles for lateral orbitofrontal cortex and lateral prefrontal cortex during preference driven reversal learning.” Neuroimage 59(4):4102-12 Details

Monti MM, Pickard JD, Owen AM (2012), “Visual cognition in disorders of consciousness: From V1 to top-down attention.” Hum Brain Mapp Details

2011

Bekinschtein TA, Davis MH, Rodd JM, Owen AM (2011), “Why clowns taste funny: the relationship between humor and semantic ambiguity.” J Neurosci 31(26):9665-71 Details

Bekinschtein TA, Manes FF, Villarreal M, Owen AM, Della-Maggiore V (2011), “Functional imaging reveals movement preparatory activity in the vegetative state.” Front Hum Neurosci 5:5 Details

Cruse D, Chennu S, Chatelle C, Bekinschtein TA, Fernández-Espejo D, Pickard JD, Laureys S, Owen AM (2011), “Bedside detection of awareness in the vegetative state: a cohort study.” Lancet 378(9809):2088-94 Details

Fernández-Espejo D, Bekinschtein T, Monti MM, Pickard JD, Junque C, Coleman MR, Owen AM (2011), “Diffusion weighted imaging distinguishes the vegetative state from the minimally conscious state.” Neuroimage 54(1):103-12 Details

2010

Cruse D, Owen AM (2010), “Consciousness revealed: new insights into the vegetative and minimally conscious states.” Curr Opin Neurol Details

Hampshire A, Chamberlain SR, Monti MM, Duncan J, Owen AM (2010), “The role of the right inferior frontal gyrus: inhibition and attentional control.” Neuroimage 50(3):1313-9 Details

Hampshire A, Thompson R, Duncan J, Owen AM (2010), “Lateral Prefrontal Cortex Subregions Make Dissociable Contributions during Fluid Reasoning.” Cereb Cortex Details

Hughes LE, Barker RA, Owen AM, Rowe JB (2010), “Parkinson's disease and healthy aging: Independent and interacting effects on action selection.” Hum Brain Mapp Details

Kempton MJ, Ettinger U, Foster R, Williams SC, Calvert GA, Hampshire A, Zelaya FO, O'Gorman RL, McMorris T, Owen AM, Smith MS (2010), “Dehydration affects brain structure and function in healthy adolescents.” Hum Brain Mapp Details

Memon FN, Owen AM, Sanchez-Graillet O, Upton GJ, Harrison AP (2010), “Identifying the impact of G-quadruplexes on Affymetrix 3' arrays using cloud computing.” J Integr Bioinform 7(2):111 Details

Monti MM, Laureys S, Owen AM (2010), “The vegetative state.” BMJ 341:c3765 Details

Piech RM, Lewis J, Parkinson CH, Owen AM, Roberts AC, Downing PE, Parkinson JA (2010), “Neural correlates of affective influence on choice.” Brain Cogn 72(2):282-8 Details

Rowe JB, Hughes LE, Barker RA, Owen AM (2010), “Dynamic causal modelling of effective connectivity from fMRI: Are results reproducible and sensitive to Parkinson's disease and its treatment?” Neuroimage Details

2009

Berry EL, Hampshire A, Rowe J, Hodges S, Kapur N, Watson P, Browne G, Smyth G, Wood K, Owen AM (2009), “The neural basis of effective memory therapy in a patient with limbic encephalitis.” J Neurol Neurosurg Psychiatry Details

Chaudhry AM, Parkinson JA, Hinton EC, Owen AM, Roberts AC (2009), “Preference judgements involve a network of structures within frontal, cingulate and insula cortices.” Eur J Neurosci 29(5):1047-55 Details

Coleman MR, Bekinschtein T, Monti MM, Owen AM, Pickard JD (2009), “A multimodal approach to the assessment of patients with disorders of consciousness.” Prog Brain Res 177:231-48 Details

Coleman MR, Davis MH, Rodd JM, Robson T, Ali A, Owen AM, Pickard JD (2009), “Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness.” Brain 132(Pt 9):2541-52 Details

Grahn JA, Parkinson JA, Owen AM (2009), “The role of the basal ganglia in learning and memory: neuropsychological studies.” Behav Brain Res 199(1):53-60 Details

Hampshire A, Thompson R, Duncan J, Owen AM (2009), “Selective tuning of the right inferior frontal gyrus during target detection.” Cogn Affect Behav Neurosci 9(1):103-12 Details

Monti MM, Coleman MR, Owen AM (2009), “Neuroimaging and the vegetative state: resolving the behavioral assessment dilemma?” Ann N Y Acad Sci 1157:81-9 Details

Monti MM, Coleman MR, Owen AM (2009), “Executive functions in the absence of behavior: functional imaging of the minimally conscious state.” Prog Brain Res 177:249-60 Details

Owen AM, Schiff ND, Laureys S (2009), “A new era of coma and consciousness science.” Prog Brain Res 177:399-411 Details

Piech RM, Lewis J, Parkinson CH, Owen AM, Roberts AC, Downing PE, Parkinson JA (2009), “Neural correlates of appetite and hunger-related evaluative judgments.” PLoS One 4(8):e6581 Details

2008

Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008), “Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.” Science 321(5887):421-2 Details

Coleman MR, Owen AM (2008), “Functional neuroimaging of disorders of consciousness.” Int Anesthesiol Clin 46(3):147-57 Details

Dove A, Manly T, Epstein R, Owen AM (2008), “The engagement of mid-ventrolateral prefrontal cortex and posterior brain regions in intentional cognitive activity.” Hum Brain Mapp 29(1):107-19 Details

Grahn JA, Parkinson JA, Owen AM (2008), “The cognitive functions of the caudate nucleus.” Prog Neurobiol 86(3):141-55 Details

Hampshire A, Gruszka A, Fallon SJ, Owen AM (2008), “Inefficiency in self-organized attentional switching in the normal aging population is associated with decreased activity in the ventrolateral prefrontal cortex.” J Cogn Neurosci 20(9):1670-86 Details

Hampshire A, Thompson R, Duncan J, Owen AM (2008), “The target selective neural response--similarity, ambiguity, and learning effects.” PLoS One 3(6):e2520 Details

Owen AM (2008), “Disorders of consciousness.” Ann N Y Acad Sci 1124:225-38 Details

Owen AM, Coleman MR (2008), “Using neuroimaging to detect awareness in disorders of consciousness.” Funct Neurol 23(4):189-94 Details

Owen AM, Coleman MR (2008), “Detecting awareness in the vegetative state.” Ann N Y Acad Sci 1129:130-8 Details

Owen AM, Coleman MR (2008), “Functional neuroimaging of the vegetative state.” Nat Rev Neurosci 9(3):235-43 Details

Rowe J, Hughes L, Eckstein D, Owen AM (2008), “Rule-selection and action-selection have a shared neuroanatomical basis in the human prefrontal and parietal cortex.” Cereb Cortex 18(10):2275-85 Details

Rowe JB, Eckstein D, Braver T, Owen AM (2008), “How does reward expectation influence cognition in the human brain?” J Cogn Neurosci 20(11):1980-92 Details

Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM (2008), “Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition.” Brain 131(Pt 8):2094-105 Details

Rowe JB, Hughes L, Williams-Gray CH, Bishop S, Fallon S, Barker RA, Owen AM (2008), “The val(158)met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.” Neurobiol Aging Details

Williams-Gray CH, Hampshire A, Barker RA, Owen AM (2008), “Attentional control in Parkinson's disease is dependent on COMT val 158 met genotype.” Brain 131(Pt 2):397-408 Details

2007

Boly M, Coleman MR, Davis MH, Hampshire A, Bor D, Moonen G, Maquet PA, Pickard JD, Laureys S, Owen AM (2007), “When thoughts become action: an fMRI paradigm to study volitional brain activity in non-communicative brain injured patients.” Neuroimage 36(3):979-92 Details

Bor D, Owen AM (2007), “Cognitive training: neural correlates of expert skills.” Curr Biol 17(3):R95-7 Details

Bor D, Owen AM (2007), “A common prefrontal-parietal network for mnemonic and mathematical recoding strategies within working memory.” Cereb Cortex 17(4):778-86 Details

Coleman MR, Rodd JM, Davis MH, Johnsrude IS, Menon DK, Pickard JD, Owen AM (2007), “Do vegetative patients retain aspects of language comprehension? Evidence from fMRI.” Brain 130(Pt 10):2494-507 Details

Davis MH, Coleman MR, Absalom AR, Rodd JM, Johnsrude IS, Matta BF, Owen AM, Menon DK (2007), “Dissociating speech perception and comprehension at reduced levels of awareness.” Proc Natl Acad Sci U S A 104(41):16032-7 Details

Hampshire A, Duncan J, Owen AM (2007), “Selective tuning of the blood oxygenation level-dependent response during simple target detection dissociates human frontoparietal subregions.” J Neurosci 27(23):6219-23 Details

Malhi GS, Lagopoulos J, Owen AM, Ivanovski B, Shnier R, Sachdev P (2007), “Reduced activation to implicit affect induction in euthymic bipolar patients: an fMRI study.” J Affect Disord 97(1-3):109-22 Details

Owen AM, Coleman MR (2007), “Functional MRI in disorders of consciousness: advantages and limitations.” Curr Opin Neurol 20(6):632-7 Details

Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD (2007), “Using functional magnetic resonance imaging to detect covert awareness in the vegetative state.” Arch Neurol 64(8):1098-102 Details

Williams-Gray CH, Hampshire A, Robbins TW, Owen AM, Barker RA (2007), “Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease.” J Neurosci 27(18):4832-8 Details

2006

Bor D, Duncan J, Lee AC, Parr A, Owen AM (2006), “Frontal lobe involvement in spatial span: converging studies of normal and impaired function.” Neuropsychologia 44(2):229-37 Details

Bor D, Owen AM (2006), “Working memory: linking capacity with selectivity.” Curr Biol 16(4):R136-8 Details

Christoff K, Owen AM (2006), “Improving reverse neuroimaging inference: cognitive domain versus cognitive complexity.” Trends Cogn Sci 10(8):352-3 Details

Dove A, Brett M, Cusack R, Owen AM (2006), “Dissociable contributions of the mid-ventrolateral frontal cortex and the medial temporal lobe system to human memory.” Neuroimage 31(4):1790-801 Details

Gould RL, Arroyo B, Brown RG, Owen AM, Bullmore ET, Howard RJ (2006), “Brain mechanisms of successful compensation during learning in Alzheimer disease.” Neurology 67(6):1011-7 Details

Gould RL, Brown RG, Owen AM, Bullmore ET, Howard RJ (2006), “Task-induced deactivations during successful paired associates learning: an effect of age but not Alzheimer's disease.” Neuroimage 31(2):818-31 Details

Grahn JA, Owen AM (2006), “Memory: obstacle avoidance without visual cues.” Curr Biol 16(7):R247-9 Details

Hinton EC, Holland AJ, Gellatly MS, Soni S, Owen AM (2006), “An investigation into food preferences and the neural basis of food-related incentive motivation in Prader-Willi syndrome.” J Intellect Disabil Res 50(Pt 9):633-42 Details

Hinton EC, Holland AJ, Gellatly MS, Soni S, Patterson M, Ghatei MA, Owen AM (2006), “Neural representations of hunger and satiety in Prader-Willi syndrome.” Int J Obes (Lond) 30(2):313-21 Details

Hon N, Epstein RA, Owen AM, Duncan J (2006), “Frontoparietal activity with minimal decision and control.” J Neurosci 26(38):9805-9 Details

Laureys S, Giacino JT, Schiff ND, Schabus M, Owen AM (2006), “How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?” Curr Opin Neurol 19(6):520-7 Details

Slabosz A, Lewis SJ, Smigasiewicz K, Szymura B, Barker RA, Owen AM (2006), “The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease.” Neuropsychology 20(5):578-88 Details

Unterrainer JM, Owen AM (2006), “Planning and problem solving: from neuropsychology to functional neuroimaging.” J Physiol Paris 99(4-6):308-17 Details

2005

Cheesman AL, Barker RA, Lewis SJ, Robbins TW, Owen AM, Brooks DJ (2005), “Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson's disease.” J Neurol Neurosurg Psychiatry 76(9):1204-10 Details

Gould RL, Brown RG, Owen AM, Bullmore ET, Williams SC, Howard RJ (2005), “Functional neuroanatomy of successful paired associate learning in Alzheimer's disease.” Am J Psychiatry 162(11):2049-60 Details

Lewis SJ, Foltynie T, Blackwell AD, Robbins TW, Owen AM, Barker RA (2005), “Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach.” J Neurol Neurosurg Psychiatry 76(3):343-8 Details

Lewis SJ, Slabosz A, Robbins TW, Barker RA, Owen AM (2005), “Dopaminergic basis for deficits in working memory but not attentional set-shifting in Parkinson's disease.” Neuropsychologia 43(6):823-32 Details

Owen AM, Coleman MR, Menon DK, Berry EL, Johnsrude IS, Rodd JM, Davis MH, Pickard JD (2005), “Using a hierarchical approach to investigate residual auditory cognition in persistent vegetative state.” Prog Brain Res 150:457-71 Details

Owen AM, Coleman MR, Menon DK, Johnsrude IS, Rodd JM, Davis MH, Taylor K, Pickard JD (2005), “Residual auditory function in persistent vegetative state: a combined PET and fMRI study.” Neuropsychol Rehabil 15(3-4):290-306 Details

Owen AM, McMillan KM, Laird AR, Bullmore E (2005), “N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies.” Hum Brain Mapp 25(1):46-59 Details

Simons JS, Gilbert SJ, Owen AM, Fletcher PC, Burgess PW (2005), “Distinct roles for lateral and medial anterior prefrontal cortex in contextual recollection.” J Neurophysiol 94(1):813-20 Details

Simons JS, Owen AM, Fletcher PC, Burgess PW (2005), “Anterior prefrontal cortex and the recollection of contextual information.” Neuropsychologia 43(12):1774-83 Details

2004

Bor D, Cumming N, Scott CE, Owen AM (2004), “Prefrontal cortical involvement in verbal encoding strategies.” Eur J Neurosci 19(12):3365-70 Details

Curran E, Sykacek P, Stokes M, Roberts SJ, Penny W, Johnsrude I, Owen AM (2004), “Cognitive tasks for driving a brain-computer interfacing system: a pilot study.” IEEE Trans Neural Syst Rehabil Eng 12(1):48-54 Details

Hinton EC, Parkinson JA, Holland AJ, Arana FS, Roberts AC, Owen AM (2004), “Neural contributions to the motivational control of appetite in humans.” Eur J Neurosci 20(5):1411-8 Details

Laureys S, Owen AM, Schiff ND (2004), “Brain function in coma, vegetative state, and related disorders.” Lancet Neurol 3(9):537-46 Details

Lewis SJ, Dove A, Robbins TW, Barker RA, Owen AM (2004), “Striatal contributions to working memory: a functional magnetic resonance imaging study in humans.” Eur J Neurosci 19(3):755-60 Details

Malhi GS, Lagopoulos J, Owen AM, Yatham LN (2004), “Bipolaroids: functional imaging in bipolar disorder.” Acta Psychiatr Scand Suppl (422):46-54 Details

Ouellet MC, Beauchamp MH, Owen AM, Doyon J (2004), “Acquiring a cognitive skill with a new repeating version of the Tower of London task.” Can J Exp Psychol 58(4):272-88 Details

Owen AM (2004), “Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry.” Neuroscientist 10(6):525-37 Details

Owen AM (2004), “Working memory: imaging the magic number four.” Curr Biol 14(14):R573-4 Details

Ramnani N, Owen AM (2004), “Anterior prefrontal cortex: insights into function from anatomy and neuroimaging.” Nat Rev Neurosci 5(3):184-94 Details

2003

Arana FS, Parkinson JA, Hinton E, Holland AJ, Owen AM, Roberts AC (2003), “Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection.” J Neurosci 23(29):9632-8 Details

Bor D, Duncan J, Wiseman RJ, Owen AM (2003), “Encoding strategies dissociate prefrontal activity from working memory demand.” Neuron 37(2):361-7 Details

Gould RL, Brown RG, Owen AM, ffytche DH, Howard RJ (2003), “fMRI BOLD response to increasing task difficulty during successful paired associates learning.” Neuroimage 20(2):1006-19 Details

Lewis SJ, Cools R, Robbins TW, Dove A, Barker RA, Owen AM (2003), “Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease.” Neuropsychologia 41(6):645-54 Details

Lewis SJ, Dove A, Robbins TW, Barker RA, Owen AM (2003), “Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry.” J Neurosci 23(15):6351-6 Details

Manly T, Owen AM, McAvinue L, Datta A, Lewis GH, Scott SK, Rorden C, Pickard J, Robertson IH (2003), “Enhancing the sensitivity of a sustained attention task to frontal damage: convergent clinical and functional imaging evidence.” Neurocase 9(4):340-9 Details

Owen AM (2003), “HERA today, gone tomorrow?” Trends Cogn Sci 7(9):383-384 Details

Tsang WM, Owen AM, Collinson PO, Barth JH (2003), “Surveys on the use of cardiac markers in the UK.” Ann Clin Biochem 40(Pt 2):138-42 Details

2002

Brett M, Johnsrude IS, Owen AM (2002), “The problem of functional localization in the human brain.” Nat Rev Neurosci 3(3):243-9 Details

Calder AJ, Lawrence AD, Keane J, Scott SK, Owen AM, Christoffels I, Young AW (2002), “Reading the mind from eye gaze.” Neuropsychologia 40(8):1129-38 Details

Cools R, Clark L, Owen AM, Robbins TW (2002), “Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging.” J Neurosci 22(11):4563-7 Details

Cools R, Stefanova E, Barker RA, Robbins TW, Owen AM (2002), “Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET.” Brain 125(Pt 3):584-94 Details

Cox SM, Stefanova E, Johnsrude IS, Robbins TW, Owen AM (2002), “Preference formation and working memory in Parkinson's disease and normal ageing.” Neuropsychologia 40(3):317-26 Details

Hodgson TL, Tiesman B, Owen AM, Kennard C (2002), “Abnormal gaze strategies during problem solving in Parkinson's disease.” Neuropsychologia 40(4):411-22 Details

Lee AC, Graham KS, Simons JS, Hodges JR, Owen AM, Patterson K (2002), “Regional brain activations differ for semantic features but not categories.” Neuroreport 13(12):1497-501 Details

Lee AC, Robbins TW, Graham KS, Owen AM (2002), “"Pray or Prey?" dissociation of semantic memory retrieval from episodic memory processes using positron emission tomography and a novel homophone task.” Neuroimage 16(3 Pt 1):724-35 Details

Lee AC, Robbins TW, Smith S, Calvert GA, Tracey I, Matthews P, Owen AM (2002), “Evidence for asymmetric frontal-lobe involvement in episodic memory from functional magnetic resonance imaging and patients with unilateral frontal-lobe excisions.” Neuropsychologia 40(13):2420-37 Details

Owen AM, Menon DK, Johnsrude IS, Bor D, Scott SK, Manly T, Williams EJ, Mummery C, Pickard JD (2002), “Detecting residual cognitive function in persistent vegetative state.” Neurocase 8(5):394-403 Details

2001

Bor D, Duncan J, Owen AM (2001), “The role of spatial configuration in tests of working memory explored with functional neuroimaging.” Scand J Psychol 42(3):217-24 Details

Dagher A, Owen AM, Boecker H, Brooks DJ (2001), “The role of the striatum and hippocampus in planning: a PET activation study in Parkinson's disease.” Brain 124(Pt 5):1020-32 Details

Rowe JB, Owen AM, Johnsrude IS, Passingham RE (2001), “Imaging the mental components of a planning task.” Neuropsychologia 39(3):315-27 Details

Simons JS, Graham KS, Owen AM, Patterson K, Hodges JR (2001), “Perceptual and semantic components of memory for objects and faces: a pet study.” J Cogn Neurosci 13(4):430-43 Details

2000

Duncan J, Owen AM (2000), “Common regions of the human frontal lobe recruited by diverse cognitive demands.” Trends Neurosci 23(10):475-83 Details

Hodgson TL, Bajwa A, Owen AM, Kennard C (2000), “The strategic control of gaze direction in the Tower-of-London task.” J Cogn Neurosci 12(5):894-907 Details

Johnsrude IS, Owen AM, White NM, Zhao WV, Bohbot V (2000), “Impaired preference conditioning after anterior temporal lobe resection in humans.” J Neurosci 20(7):2649-56 Details

Lee AC, Robbins TW, Owen AM (2000), “Episodic memory meets working memory in the frontal lobe: functional neuroimaging studies of encoding and retrieval.” Crit Rev Neurobiol 14(3-4):165-97 Details

Lee AC, Robbins TW, Pickard JD, Owen AM (2000), “Asymmetric frontal activation during episodic memory: the effects of stimulus type on encoding and retrieval.” Neuropsychologia 38(5):677-92 Details

Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW (2000), “Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain.” J Neurosci 20(6):RC65 Details

Owen AM (2000), “The role of the lateral frontal cortex in mnemonic processing: the contribution of functional neuroimaging.” Exp Brain Res 133(1):33-43 Details

Stern CE, Owen AM, Tracey I, Look RB, Rosen BR, Petrides M (2000), “Activity in ventrolateral and mid-dorsolateral prefrontal cortex during nonspatial visual working memory processing: evidence from functional magnetic resonance imaging.” Neuroimage 11(5 Pt 1):392-9 Details

Vandenberghe R, Duncan J, Arnell KM, Bishop SJ, Herrod NJ, Owen AM, Minhas PS, Dupont P, Pickard JD, Orban GA (2000), “Maintaining and shifting attention within left or right hemifield.” Cereb Cortex 10(7):706-13 Details

1999

Dagher A, Owen AM, Boecker H, Brooks DJ (1999), “Mapping the network for planning: a correlational PET activation study with the Tower of London task.” Brain 122 ( Pt 10):1973-87 Details

Johnsrude IS, Owen AM, Crane J, Milner B, Evans AC (1999), “A cognitive activation study of memory for spatial relationships.” Neuropsychologia 37(7):829-41 Details

Menon DK, Owen AM, Pickard JD (1999), “Response from Menon, Owen and Pickard.” Trends Cogn Sci 3(2):44-46 Details

Owen AM, Doyon J (1999), “The cognitive neuropsychology of Parkinson's disease: a functional neuroimaging perspective.” Adv Neurol 80:49-56 Details

Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SP, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD (1999), “Redefining the functional organization of working memory processes within human lateral prefrontal cortex.” Eur J Neurosci 11(2):567-74 Details

Pantelis C, Barber FZ, Barnes TR, Nelson HE, Owen AM, Robbins TW (1999), “Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage.” Schizophr Res 37(3):251-70 Details

Rogers RD, Owen AM, Middleton HC, Williams EJ, Pickard JD, Sahakian BJ, Robbins TW (1999), “Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex.” J Neurosci 19(20):9029-38 Details

1998

Menon DK, Owen AM, Williams EJ, Minhas PS, Allen CM, Boniface SJ, Pickard JD (1998), “Cortical processing in persistent vegetative state. Wolfson Brain Imaging Centre Team.” Lancet 352(9123):200 Details

Owen AM (1998), “Memory: dissociating multiple memory processes.” Curr Biol 8(23):R850-2 Details

Owen AM, Doyon J, Dagher A, Sadikot A, Evans AC (1998), “Abnormal basal ganglia outflow in Parkinson's disease identified with PET. Implications for higher cortical functions.” Brain 121 ( Pt 5):949-65 Details

Owen AM, Stern CE, Look RB, Tracey I, Rosen BR, Petrides M (1998), “Functional organization of spatial and nonspatial working memory processing within the human lateral frontal cortex.” Proc Natl Acad Sci U S A 95(13):7721-6 Details

Robbins TW, James M, Owen AM, Sahakian BJ, Lawrence AD, McInnes L, Rabbitt PM (1998), “A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging.Cambridge Neuropsychological Test Automated Battery.” J Int Neuropsychol Soc 4(5):474-90 Details

1997

Owen AM (1997), “Cognitive planning in humans: neuropsychological, neuroanatomical and neuropharmacological perspectives.” Prog Neurobiol 53(4):431-50 Details

Owen AM (1997), “The functional organization of working memory processes within human lateral frontal cortex: the contribution of functional neuroimaging.” Eur J Neurosci 9(7):1329-39 Details

Owen AM, Iddon JL, Hodges JR, Summers BA, Robbins TW (1997), “Spatial and non-spatial working memory at different stages of Parkinson's disease.” Neuropsychologia 35(4):519-32 Details

Pantelis C, Barnes TR, Nelson HE, Tanner S, Weatherley L, Owen AM, Robbins TW (1997), “Frontal-striatal cognitive deficits in patients with chronic schizophrenia.” Brain 120 ( Pt 10):1823-43 Details

1996

Baker SC, Rogers RD, Owen AM, Frith CD, Dolan RJ, Frackowiak RS, Robbins TW (1996), “Neural systems engaged by planning: a PET study of the Tower of London task.” Neuropsychologia 34(6):515-26 Details

Doyon J, Owen AM, Petrides M, Sziklas V, Evans AC (1996), “Functional anatomy of visuomotor skill learning in human subjects examined with positron emission tomography.” Eur J Neurosci 8(4):637-48 Details

Owen AM, Doyon J, Petrides M, Evans AC (1996), “Planning and spatial working memory: a positron emission tomography study in humans.” Eur J Neurosci 8(2):353-64 Details

Owen AM, Evans AC, Petrides M (1996), “Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study.” Cereb Cortex 6(1):31-8 Details

Owen AM, Milner B, Petrides M, Evans AC (1996), “Memory for object features versus memory for object location: a positron-emission tomography study of encoding and retrieval processes.” Proc Natl Acad Sci U S A 93(17):9212-7 Details

Owen AM, Morris RG, Sahakian BJ, Polkey CE, Robbins TW (1996), “Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man.” Brain 119 ( Pt 5):1597-615 Details

Veale DM, Sahakian BJ, Owen AM, Marks IM (1996), “Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder.” Psychol Med 26(6):1261-9 Details

1995

Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW (1995), “Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man.” Neuropsychologia 33(1):1-24 Details

1994

Robbins TW, James M, Owen AM, Lange KW, Lees AJ, Leigh PN, Marsden CD, Quinn NP, Summers BA (1994), “Cognitive deficits in progressive supranuclear palsy, Parkinson's disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction.” J Neurol Neurosurg Psychiatry 57(1):79-88 Details

Robbins TW, James M, Owen AM, Sahakian BJ, McInnes L, Rabbitt P (1994), “Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers.” Dementia 5(5):266-81 Details

1993

Owen AM, Beksinska M, James M, Leigh PN, Summers BA, Marsden CD, Quinn NP, Sahakian BJ, Robbins TW (1993), “Visuospatial memory deficits at different stages of Parkinson's disease.” Neuropsychologia 31(7):627-44 Details

Owen AM, Roberts AC, Hodges JR, Summers BA, Polkey CE, Robbins TW (1993), “Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease.” Brain 116 ( Pt 5):1159-75 Details

Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S, Crayton L, Crockford HA, Crooks M, Hill K, Levy R (1993), “Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB.” Psychopharmacology (Berl) 110(4):395-401 Details

1992

Lange KW, Robbins TW, Marsden CD, James M, Owen AM, Paul GM (1992), “L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction.” Psychopharmacology (Berl) 107(2-3):394-404 Details

Owen AM, James M, Leigh PN, Summers BA, Marsden CD, Quinn NP, Lange KW, Robbins TW (1992), “Fronto-striatal cognitive deficits at different stages of Parkinson's disease.” Brain 115 ( Pt 6):1727-51 Details

Robbins TW, James M, Lange KW, Owen AM, Quinn NP, Marsden CD (1992), “Cognitive performance in multiple system atrophy.” Brain 115 Pt 1:271-91 Details

Sahakian BJ, Owen AM (1992), “Computerized assessment in neuropsychiatry using CANTAB: discussion paper.” J R Soc Med 85(7):399-402 Details

1991

Förstl H, Almeida OP, Owen AM, Burns A, Howard R (1991), “Psychiatric, neurological and medical aspects of misidentification syndromes: a review of 260 cases.” Psychol Med 21(4):905-10 Details

Owen AM, Roberts AC, Polkey CE, Sahakian BJ, Robbins TW (1991), “Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man.” Neuropsychologia 29(10):993-1006 Details

1990

Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW (1990), “Planning and spatial working memory following frontal lobe lesions in man.” Neuropsychologia 28(10):1021-34 Details