Dr Andrea Delekate
Together with my supervisor Dennis Chan we are interested in the investigation of early symptoms during the development of Alzheimer's disease (AD) in the Entorhinal cortex (EC) and hippocampus. My work will address this question by using an animal model of AD.
I am located in the lab of Nobel Laureate Professor John O’Keefe at UCL where I will perform studies addressing the function of EC grid cells and hippocampal place cells and their behavioural correlates in an AD mouse model.
In addition we aim to have a deeper view into cellular functions and thereby reveal possible pathological changes with in vivo multiphoton calcium imaging in the same animals.
Field potential recording
No collaborators listed
Associated News Items
Delekate A, Füchtemeier M, Schumacher T, Ulbrich C, Foddis M, Petzold GC (2014), “Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model.” Nat Commun 5:5422 Details
Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME (2014), “The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.” PLoS Biol 12(1):e1001763 Details
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013), “NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.” Nature 493(7434):674-8 Details
Delekate A, Zagrebelsky M, Kramer S, Schwab ME, Korte M (2011), “NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale.” Proc Natl Acad Sci U S A 108(6):2569-74 Details
Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT (2011), “Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.” Neuron 71(5):833-44 Details
Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC (2011), “APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.” EMBO J 30(11):2266-80 Details