Interests

I am interested in biophysics and physiology of the vertebrate inner ear , especially the cochlea. My research has focussed on the electrophysiology of cochlear hair cells with a view to understanding how they manage to respond to nanometre displacements at frequencies of many tens of kilohertz. Currently we are particularly interested in the motor and sensory functions of mammalian outer hair cells including the micromechanics of stereocilia and their role in both sensory transduction and force feedback. Damage to the cochlear hair cells, or the nerve fibres that supply them, is a common - maybe the most common - cause of adult hearing loss.

Research Focus

Keywords

hair cells

cochlea

inner ear

sensory transduction

micromechanics

Clinical conditions

Deafness

Hearing and balance deficits

Menierre's disease

Equipment

Calcium imaging

Electrophysiological recording techniques

Fluorescence microscopy

Generation of rapid nanometre and piconewton stimuli

Intracellular recording

Measurement of rapid nanometre displacements and piconewton forces by cells and organelles

Microscopy

Whole cell patch clamp

Collaborators

United Kingdom

Mike Evans Web: http://www.keele.ac.uk/depts/b...

Helen Kennedy Web: http://www.bris.ac.uk/Depts/P...

Corne Kros Web: http://www.sussex.ac.uk/biology...

International

Maryline Beurg Web: http://www.inbtest.u-bordeaux2.fr

Robert Fettiplace Web: http://www.physiology.wisc.edu/faculty...

Publications

2006

Kennedy HJ, Evans MG, Crawford AC, Fettiplace R (2006), “Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms.” J Neurosci 26(10):2757-66 Details

2005

Kennedy HJ, Crawford AC, Fettiplace R (2005), “Force generation by mammalian hair bundles supports a role in cochlear amplification.” Nature 433(7028):880-3 Details

Ricci AJ, Kennedy HJ, Crawford AC, Fettiplace R (2005), “The transduction channel filter in auditory hair cells.” J Neurosci 25(34):7831-9 Details

2003

Kennedy HJ, Evans MG, Crawford AC, Fettiplace R (2003), “Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells.” Nat Neurosci 6(8):832-6 Details

Ricci AJ, Crawford AC, Fettiplace R (2003), “Tonotopic variation in the conductance of the hair cell mechanotransducer channel.” Neuron 40(5):983-90 Details