Dr Akhilesh Reddy

Akhilesh Reddy

University position

Wellcome Trust Senior Fellow in Clinical Sciences

Dr Akhilesh Reddy is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Institute of Metabolic Science

Email

abr20@cam.ac.uk

Home page

http://www.mrl.ims.cam.ac.uk/staff/A...

Research Themes

Cellular and Molecular Neuroscience

Systems and Computational Neuroscience

Interests

My group is interested in circadian rhythms, which are daily cycles of physiology and behaviour that persist when organisms are isolated from the outside world. They represent a fundamental biological mechanism, and are present at all levels of life, from bacteria through to humans. They allow us to anticipate and thus adapt to the solar cycle of night and day.

In humans, the sleep-wake cycle is the most obvious circadian rhythm but other, more subtle, endocrine rhythms coordinate our body's physiology. Disruption of our circadian programming through old age, neurological disease, and even shift-work, is a growing cause of significant morbidity. Of note, disorders of metabolism, as well as cancer, have now been closely linked to circadian dysfunction.

We are applying a range of systems-level approaches (e.g. next generation sequencing, real-time imaging and proteomics) to deconstruct how the clock works and to elucidate how it controls the sleep wake cycle and cellular metabolism.

Differential In-Gel Electrophoresis (DIGE) identifies circadian (daily) protein expression patterns.
Differential In-Gel Electrophoresis (DIGE) identifies circadian (daily) protein expression patterns.
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Research Focus

Keywords

Circadian

Metabolism

Sleep

Genomics

Proteomics

Clinical conditions

Bipolar disorder

Cancers

Dementia

Depressive disorders

Diabetes

Huntington's disease

Parkinson's disease

Seasonal affective disorder

Sleep disorders

Equipment

Behavioural analysis

Calcium imaging

Cell culture

Computational modelling

Confocal microscopy

Electroencephalography (EEG)

Enzyme assays

Fluorescence microscopy

FPLC/HPLC

Immunohistochemistry

Microarrays

Microscopy

Next generation sequencing (Illumina)

Protein purification

Proteomics

Real-time bioluminscent imaging

Recombinant protein expression

Collaborators

Cambridge

Roger Barker

Michael Hastings

Liz Maywood

Jenny Morton

Key publications

Breen DP, Vuono R, Nawarathna U, Fisher K, Shneerson JM, Reddy AB, Barker RA (2014), “Sleep and circadian rhythm regulation in early Parkinson disease.” JAMA Neurol 71(5):589-95 Details

Reddy AB, Rey G (2014), “Metabolic and Nontranscriptional Circadian Clocks: Eukaryotes.” Annu Rev Biochem Details

Rey G, Reddy AB (2013), “Physiology. Rhythmic respiration.” Science 342(6158):570-1 Details

Valekunja UK, Edgar RS, Oklejewicz M, van der Horst GT, O'Neill JS, Tamanini F, Turner DJ, Reddy AB (2013), “Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.” Proc Natl Acad Sci U S A 110(4):1554-9 Details

Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O'Neill JS, Reddy AB (2012), “Peroxiredoxins are conserved markers of circadian rhythms.” Nature 485(7399):459-64 Details

Olmedo M, O'Neill JS, Edgar RS, Valekunja UK, Reddy AB, Merrow M (2012), “Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans.” Proc Natl Acad Sci U S A 109(50):20479-84 Details

O'Neill JS, Reddy AB (2011), “Circadian clocks in human red blood cells.” Nature 469(7331):498-503 Details

O'Neill JS, van Ooijen G, Dixon LE, Troein C, Corellou F, Bouget FY, Reddy AB, Millar AJ (2011), “Circadian rhythms persist without transcription in a eukaryote.” Nature 469(7331):554-8 Details

Publications

2013

Rey G, Reddy AB (2013), “Connecting cellular metabolism to circadian clocks.” Trends Cell Biol 23(5):234-41 Details

Stangherlin A, Reddy AB (2013), “Regulation of circadian clocks by redox homeostasis.” J Biol Chem 288(37):26505-11 Details

Wu L, Reddy AB (2013), “Disrupting rhythms: diet-induced obesity impairs diurnal rhythms in metabolic tissues.” Diabetes 62(6):1829-30 Details

2011

Reddy AB, O'Neill JS (2011), “Metaclocks.” EMBO Rep 12(7):612 Details

2008

Hastings MH, Maywood ES, Reddy AB (2008), “Two decades of circadian time.” J Neuroendocrinol 20(6):812-9 Details

2007

Maywood ES, O'Neill JS, Reddy AB, Chesham JE, Prosser HM, Kyriacou CP, Godinho SI, Nolan PM, Hastings MH (2007), “Genetic and molecular analysis of the central and peripheral circadian clockwork of mice.” Cold Spring Harb Symp Quant Biol 72:85-94 Details

Reddy AB, Maywood ES (2007), “Circadian rhythms: per2bations in the liver clock.” Curr Biol 17(8):R292-4 Details

Reddy AB, Maywood ES, Karp NA, King VM, Inoue Y, Gonzalez FJ, Lilley KS, Kyriacou CP, Hastings MH (2007), “Glucocorticoid signaling synchronizes the liver circadian transcriptome.” Hepatology 45(6):1478-88 Details

2006

Maywood ES, O'Neill J, Wong GK, Reddy AB, Hastings MH (2006), “Circadian timing in health and disease.” Prog Brain Res 153:253-69 Details

Maywood ES, Reddy AB, Wong GK, O'Neill JS, O'Brien JA, McMahon DG, Harmar AJ, Okamura H, Hastings MH (2006), “Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling.” Curr Biol 16(6):599-605 Details

Reddy AB, Karp NA, Maywood ES, Sage EA, Deery M, O'Neill JS, Wong GK, Chesham J, Odell M, Lilley KS, Kyriacou CP, Hastings MH (2006), “Circadian orchestration of the hepatic proteome.” Curr Biol 16(11):1107-15 Details

Reddy AB, Karp NA, Maywood ES, Sage EA, O’Neill J, Wong GYK, Odell M, Lilley KS, Kyriacou CP and Hastings MH (2006), “ Circadian coordination of the hepatic proteome” Current Biology 16(11):1107-15

2005

Hastings MH, Reddy AB, McMahon DG, Maywood ES (2005), “Analysis of circadian mechanisms in the suprachiasmatic nucleus by transgenesis and biolistic transfection.” Methods Enzymol 393:579-92 Details

Reddy AB, Wong GK, O'Neill J, Maywood ES, Hastings MH (2005), “Circadian clocks: neural and peripheral pacemakers that impact upon the cell division cycle.” Mutat Res 574(1-2):76-91 Details

2003

Hastings MH, Reddy AB, Garabette M, King VM, Chahad-Ehlers S, O'Brien J, Maywood ES (2003), “Expression of clock gene products in the suprachiasmatic nucleus in relation to circadian behaviour.” Novartis Found Symp 253:203-17; discussion 102-9, 218-22, 281-4 Details

Hastings MH, Reddy AB, Maywood ES (2003), “A clockwork web: circadian timing in the brain and periphery, in health and disease” Nature Reviews Neuroscience 4(8):649-61

Hastings MH, Reddy AB, Maywood ES (2003), “A clockwork web: circadian timing in brain and periphery, in health and disease.” Nat Rev Neurosci 4(8):649-61 Details

2002

Akhtar RA*, Reddy AB*, Maywood ES, Clayton JD, King VM, Smith AG, Gant TW, Hastings MH, Kyriacou CP (2002), “Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus” Current Biology 12(7):540-50

Akhtar RA, Reddy AB, Maywood ES, Clayton JD, King VM, Smith AG, Gant TW, Hastings MH, Kyriacou CP (2002), “Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus.” Curr Biol 12(7):540-50 Details

Reddy AB, Field MD, Maywood ES, and Hastings MH (2002), “Differential resynchronisation of circadian clock gene expression within the suprachiasmatic nuclei of mice subjected to experimental jet lag” Journal of Neuroscience 22(17):7326-30

Reddy AB, Field MD, Maywood ES, Hastings MH (2002), “Differential resynchronisation of circadian clock gene expression within the suprachiasmatic nuclei of mice subjected to experimental jet lag.” J Neurosci 22(17):7326-30 Details