Dr Akhilesh Reddy
Wellcome Trust Senior Fellow in Clinical Sciences
Dr Akhilesh Reddy is pleased to consider applications from prospective PhD students.
My group is interested in circadian rhythms, which are daily cycles of physiology and behaviour that persist when organisms are isolated from the outside world. They represent a fundamental biological mechanism, and are present at all levels of life, from bacteria through to humans. They allow us to anticipate and thus adapt to the solar cycle of night and day.
In humans, the sleep-wake cycle is the most obvious circadian rhythm but other, more subtle, endocrine rhythms coordinate our body's physiology. Disruption of our circadian programming through old age, neurological disease, and even shift-work, is a growing cause of significant morbidity. Of note, disorders of metabolism, as well as cancer, have now been closely linked to circadian dysfunction.
We are applying a range of systems-level approaches (e.g. next generation sequencing, real-time imaging and proteomics) to deconstruct how the clock works and to elucidate how it controls the sleep wake cycle and cellular metabolism.
Seasonal affective disorder
Next generation sequencing (Illumina)
Real-time bioluminscent imaging
Recombinant protein expression
Rey G, Reddy AB (2013), “Connecting cellular metabolism to circadian clocks.” Trends Cell Biol Details
Valekunja UK, Edgar RS, Oklejewicz M, van der Horst GT, O'Neill JS, Tamanini F, Turner DJ, Reddy AB (2013), “Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.” Proc Natl Acad Sci U S A 110(4):1554-9 Details
Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O'Neill JS, Reddy AB (2012), “Peroxiredoxins are conserved markers of circadian rhythms.” Nature 485(7399):459-64 Details
Olmedo M, O'Neill JS, Edgar RS, Valekunja UK, Reddy AB, Merrow M (2012), “Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans.” Proc Natl Acad Sci U S A 109(50):20479-84 Details
O'Neill JS, Reddy AB (2011), “Circadian clocks in human red blood cells.” Nature 469(7331):498-503 Details
O'Neill JS, van Ooijen G, Dixon LE, Troein C, Corellou F, Bouget FY, Reddy AB, Millar AJ (2011), “Circadian rhythms persist without transcription in a eukaryote.” Nature 469(7331):554-8 Details
Reddy AB, O'Neill JS (2011), “Metaclocks.” EMBO Rep 12(7):612 Details
Reddy AB, Karp NA, Maywood ES, Sage EA, O’Neill J, Wong GYK, Odell M, Lilley KS, Kyriacou CP and Hastings MH (2006), “ Circadian coordination of the hepatic proteome” Current Biology 16(11):1107-15
Hastings MH, Reddy AB, Maywood ES (2003), “A clockwork web: circadian timing in the brain and periphery, in health and disease” Nature Reviews Neuroscience 4(8):649-61
Akhtar RA*, Reddy AB*, Maywood ES, Clayton JD, King VM, Smith AG, Gant TW, Hastings MH, Kyriacou CP (2002), “Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus” Current Biology 12(7):540-50
Reddy AB, Field MD, Maywood ES, and Hastings MH (2002), “Differential resynchronisation of circadian clock gene expression within the suprachiasmatic nuclei of mice subjected to experimental jet lag” Journal of Neuroscience 22(17):7326-30