Dr Alex Bayes
University position
Research Associate
Institutes
Home page
http://www.sanger.ac.uk/Teams/T...
Research Themes
Interests
My main research topics are:
1) The study of the evolution of synapse protein composition.
2) The identification of the molecular mechanisms involved in learning and memory using proteomic approaches and genetically modified mice.
Proteomics is the main technique which I am using to address both fields of research.
These studies are a part of the Genes to Cognition research consortium that integrates many experimental approaches in order to understand genetic contribution to behaviour and disease.
Research Focus
Keywordslearning and memory plasticity synapse evolution proteomics |
Clinical conditionsAlzheimer's disease Bipolar disorder Borderline personality disorder Cognitive impairment Genetic disorders Learning disabilities Schizophrenia |
Equipment
Proteomics
Collaborators
No collaborators listed
Publications
2012
Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, Moran J, Chambert K, Toncheva D, Georgieva L, Grozeva D, Fjodorova M, Wollerton R, Rees E, Nikolov I, Lagemaat LN, Bayés A, Fernandez E, Olason PI, Böttcher Y, Komiyama NH, Collins MO, Choudhary J, Stefansson K, Stefansson H, Grant SG, Purcell S, Sklar P, O'Donovan MC, Owen MJ (2012), “De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.” Mol Psychiatry 17(2):142-53 Details
2011
Bayes A & Grant SGN (2011), “Postsynaptic Proteins Play a Major Role in Neurological and Psychiatric Disease” Advances in Clinical Neurosciences and Rehabilitation 11 (4), 13-14
Bayés A, van de Lagemaat LN, Collins MO, Croning MD, Whittle IR, Choudhary JS, Grant SG (2011), “Characterization of the proteome, diseases and evolution of the human postsynaptic density.” Nat Neurosci 14(1):19-21 Details
2010
Delint-Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama NH, Grant SG (2010), “In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.” J Neurosci 30(24):8162-70 Details
2009
Bayés A, Grant SG (2009), “Neuroproteomics: understanding the molecular organization and complexity of the brain.” Nat Rev Neurosci 10(9):635-46 Details
2008
Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG (2008), “Evolutionary expansion and anatomical specialization of synapse proteome complexity.” Nat Neurosci 11(7):799-806 Details
Research and Collaboration
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