Dr Alpar Lazar

Interests

My main research area is sleep, circadian rhythm and cognition in neurodegenerative diseases.

My scope is to investigate the deep structure of sleep EEG activity in relation to circadian rhythm, cognition and metabolism and the way it changes over time as patients carrying the HD (Huntington’s disease) gene mutation approach disease onset. For this I use different mathematical procedures which can detect even minor changes in the sleep EEG. We aim to identify sleep related early markers for the onset and prognosis of HD.

I also study the efficacy of non-pharmaceutical approaches to improve sleep quality in manifest patients with HD.

Research Focus

Keywords

Sleep

Circadian

Cognition

Electroencephalography

Huntington's disease

Clinical conditions

Dementia

Huntington's disease

Parkinson's disease

Sleep disorders

Equipment

Actigraphy

Behavioural analysis

Electroencephalography (EEG)

Electrophysiological recording techniques

Indirect calorimetry

Neuropsychological testing

Collaborators

Cambridge

Roger Barker

David Breen

Sarah Mason

Natalie Valle Guzman

United Kingdom

Derk-Jan Dijk Web: http://www.surrey.ac.uk/biochem...

Anna Goodman

International

Robert Bodizs Web: http://www.bodizs-lab.hu/people/...

Zsolt Lazar Web: http://phys.ubbcluj.ro/index_e...

Istvan Mucsi Web: http://en.mucsi.net/menu/1001

Associated News Items


    Publications

    in press

    Atherton KE, Nobre AC, Lazar AS, Wulff K, Whittaker RG, Dhawan V, Lazar ZI, Zeman AZ, Butler CR (in press), “Slow wave sleep and accelerated forgetting” Cortex

    2016

    Bartlett DM, Cruickshank TM, Hannan AJ, Eastwood PR, Lazar AS, Ziman MR. (2016), “Neuroendocrine and Neurotrophic Signaling in Huntington's Disease: Implications for Pathogenic Mechanisms and Treatment Strategies” Neurosci Biobehav Rev 2016 Sep 13. pii: S0149-7634(16)30276-7

    Santhi N, Lazar AS, McCabe PJ, Lo JC, Groeger JA, Dijk DJ. (2016), “Sex differences in the circadian regulation of sleep and waking cognition in humans.” Proc Natl Acad Sci U S A pii: 201521637. [Epub ahead of print]

    2015

    Collins LM, Begeti F, Panin F, Lazar AS, Cruickshank T, Ziman M, Mason SL, Barker RA. (2015), “Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease.” PLoS Curr. 2015 Sep 8;7.

    Lazar AS, Lazar ZI, Dijk DJ (2015), “Circadian regulation of slow waves in human sleep: Topographical aspects.” Neuroimage 116:123-34 Details

    Lazar AS, Panin F, Goodman AO, Lazic SE, Lazar ZI, Mason SL, Rogers L, Murgatroyd PR, Watson LP, Singh P, Borowsky B, Shneerson JM, Barker RA. (2015), “Sleep deficits but no metabolic deficits in premanifest Huntington's disease.” Ann Neurol 78(4):630-48

    Mason SL, Zhang J, Begeti F, Guzman NV, Lazar AS, Rowe JB, Barker RA, Hampshire A (2015), “The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease.” Neuropsychologia 70:80-9 Details

    2014

    Archer SN, Laing EE, Möller-Levet CS, van der Veen DR, Bucca G, Lazar AS, Santhi N, Slak A, Kabiljo R, von Schantz M, Smith CP, Dijk DJ (2014), “Mistimed sleep disrupts circadian regulation of the human transcriptome.” Proc Natl Acad Sci U S A 111(6):E682-91 Details

    Kuan WL, Kasis A, Yuan Y, Mason SL, Lazar AS, Barker RA, Goncalves J (2014), “Modelling the natural history of Huntington's disease progression.” J Neurol Neurosurg Psychiatry Details

    Videnovic A, Lazar AS, Barker RA, Overeem S (2014), “'The clocks that time us'--circadian rhythms in neurodegenerative disorders.” Nat Rev Neurol 10(12):683-93 Details

    2013

    Lazar AS, Santhi N, Hasan S, Lo JC, Johnston J, von Schantz M, Archer SN, Dijk DJ. (2013), “Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory” J Sleep Res Apr;22(2):155-9.

    2012

    Fornadi K, Lindner A, Czira ME, Szentkiralyi A, Lazar AS, Zoller R, Turanyi CZ, Veber O, Novak M, Mucsi I, Molnar MZ (2012), “Lack of association between objectively assessed sleep disorders and inflammatory markers among kidney transplant recipients.” Int Urol Nephrol 44(2):607-17 Details

    Hasan S, Santhi N, Lazar AS, Slak A, Lo J, von Schantz M, Archer SN, Johnston JD, Dijk DJ (2012), “Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.” FASEB J 26(6):2414-23 Details

    Lázár AS, Slak A, Lo JC, Santhi N, von Schantz M, Archer SN, Groeger JA, Dijk DJ (2012), “Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.” Chronobiol Int 29(2):131-46 Details

    Lindner A, Fornadi K, Lazar AS, Czira ME, Dunai A, Zoller R, Veber O, Szentkiralyi A, Kiss Z, Toronyi E, Mucsi I, Novak M, Molnar MZ (2012), “Periodic limb movements in sleep are associated with stroke and cardiovascular risk factors in patients with renal failure.” J Sleep Res 21(3):297-307 Details

    Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, von Schantz M, Archer SN, Dijk DJ (2012), “Effects of Partial and Acute Total Sleep Deprivation on Performance across Cognitive Domains, Individuals and Circadian Phase.” PLoS One 7(9):e45987 Details

    2010

    Lázár AS, Lázár ZI, Bíró A, Gyori M, Tárnok Z, Prekop C, Keszei A, Stefanik K, Gádoros J, Halász P, Bódizs R (2010), “Reduced fronto-cortical brain connectivity during NREM sleep in Asperger syndrome: an EEG spectral and phase coherence study.” Clin Neurophysiol 121(11):1844-54 Details

    Molnar MZ, Lazar AS, Lindner A, Fornadi K, Czira ME, Dunai A, Zoller R, Szentkiralyi A, Rosivall L, Shapiro CM, Novak M, Mucsi I (2010), “Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients.” Clin J Am Soc Nephrol 5(1):125-32 Details

    2009

    Bódizs R, Körmendi J, Rigó P, Lázár AS (2009), “The individual adjustment method of sleep spindle analysis: methodological improvements and roots in the fingerprint paradigm.” J Neurosci Methods 178(1):205-13 Details

    2008

    Bódizs R, Lázár AS, Rigó P (2008), “Correlation of visuospatial memory ability with right parietal EEG spindling during sleep.” Acta Physiol Hung 95(3):297-306 Details

    Lázár AS, Bódizs R (2008), “[The structure and patterns of sleep in autism spectrum disorders].” Psychiatr Hung 23(2):109-28 Details

    2006

    Bódizs R, Lázár AS (2006), “Schizophrenia, slow wave sleep and visuospatial memory: sleep-dependent consolidation or trait-like correlation?” J Psychiatr Res 40(1):89-90 Details

    2005

    Bódizs R, Kis T, Lázár AS, Havrán L, Rigó P, Clemens Z, Halász P (2005), “Prediction of general mental ability based on neural oscillation measures of sleep.” J Sleep Res 14(3):285-92 Details

    Bódizs R, Sverteczki M, Lázár AS, Halász P (2005), “Human parahippocampal activity: non-REM and REM elements in wake-sleep transition.” Brain Res Bull 65(2):169-76 Details