Dr Xana Almeida

University position

Research Associate

Departments

Department of Physiology, Development and Neuroscience

Institutes

PDN

Email

aaa46@cam.ac.uk

Home page

http://www.pdn.cam.ac.uk/staff/h...

Research Themes

Developmental Neuroscience

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

During neural development the proper number of each specific cell type must be generated at the correct time and place. Thus, a precise balance between cell division, cell survival, cell cycle exit and differentiation must be achieved. However, the mechanisms by which these different processes are coordinated remain poorly understood.

Using the highly structured retina as a model to investigate the mechanisms that regulate cell fate determination, we study how multipotent retinal progenitors give rise to the six retinal neuron types.

Polychrome fish

Research Focus

Keywords

proliferation

differentiation

development

retina

zebrafish

Clinical conditions

Birth defects

Visual Impairment

Equipment

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Collaborators

No collaborators listed

Key publications

Jusuf PR, Almeida AD, Randlett O, Joubin K, Poggi L, Harris WA (2011), “Origin and determination of inhibitory cell lineages in the vertebrate retina.” J Neurosci 31(7):2549-62 Details

Publications

2010

Almeida AD, Wise HM, Hindley CJ, Slevin MK, Hartley RS, Philpott A (2010), “The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis.” Neural Dev 5:1 Details

2007

Morris SA, Almeida AD, Tanaka H, Ohta K, Ohnuma S (2007), “Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation.” PLoS One 2(10):e1004 Details

2005

Grãos M, Almeida AD, Chatterjee S (2005), “Growth-factor-dependent phosphorylation of Bim in mitosis.” Biochem J 388(Pt 1):185-94 Details