Dr Xana Almeida
During neural development the proper number of each specific cell type must be generated at the correct time and place. Thus, a precise balance between cell division, cell survival, cell cycle exit and differentiation must be achieved. However, the mechanisms by which these different processes are coordinated remain poorly understood.
Using the highly structured retina as a model to investigate the mechanisms that regulate cell fate determination, we study how multipotent retinal progenitors give rise to the six retinal neuron types.
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Jusuf PR, Almeida AD, Randlett O, Joubin K, Poggi L, Harris WA (2011), “Origin and determination of inhibitory cell lineages in the vertebrate retina.” J Neurosci 31(7):2549-62 Details
Almeida AD, Wise HM, Hindley CJ, Slevin MK, Hartley RS, Philpott A (2010), “The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis.” Neural Dev 5:1 Details
Morris SA, Almeida AD, Tanaka H, Ohta K, Ohnuma S (2007), “Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation.” PLoS One 2(10):e1004 Details
Grãos M, Almeida AD, Chatterjee S (2005), “Growth-factor-dependent phosphorylation of Bim in mitosis.” Biochem J 388(Pt 1):185-94 Details