Professor Tony Holland

Tony Holland

University position

Professor

Professor Tony Holland is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Email

ajh1008@cam.ac.uk

Home page

http://www.ciddrg.org.uk (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Developmental Neuroscience

Interests

The focus of our interdisciplinary research is on learning disabilities (intellectual disabilities/mental handicap) from different perspectives. Research to date has had the following main themes. First, the relationship between specific genetically determined neurodevelopmental disorders and patterns of development and associated co-morbidities. Research projects have included studies of Prader Willi Syndrome and the associated eating disorder and risks of psychiatric illness; and investigations of the links between Down's syndrome and the high risk for developing Alzheimer's disease. Secondly, studies investigating the interface between people with learning disabilities and the law. This has included research to inform the Mental Capacity Act 2005 and to investigate offending by people with learning disabilies. Thirdly, sociological studies broadly on the theme of 'citizenship' with respect to people with learning disabilities. Since 2008 our group has been part of the NIHR CLAHRC.

Research Focus

Keywords

learning disabilities

intellectual disabilities

behavioural phenotype

mental health

Clinical conditions

Alzheimer's disease

Autism

Birth defects

Cognitive impairment

Dementia

Depressive disorders

Genetic disorders

Learning disabilities

Equipment

Behavioural analysis

Computerised tomography

Cross-sectional and cohort studies

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Marcus Redley

Key publications

Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using Positron Emission Tomography and Carbon 11-Labeled Pittsburgh Compound B to Image Brain Fibrillar {beta}-Amyloid in Adults With Down Syndrome: Safety, Acceptability, and Feasibility.” Arch Neurol Details

McAllister CJ, Whittington JE, Holland AJ (2011), “Development of the eating behaviour in Prader-Willi Syndrome: advances in our understanding.” Int J Obes (Lond) 35(2):188-97 Details

Ball SL, Holland AJ, Watson PC, Huppert FA (2010), “Theoretical exploration of the neural bases of behavioural disinhibition, apathy and executive dysfunction in preclinical Alzheimer's disease in people with Down's syndrome: potential involvement of multiple frontal-subcortical neuronal circuits.” J Intellect Disabil Res 54(4):320-36 Details

Publications

2014

Clarke G, Galbraith S, Woodward J, Holland AJ, Barclay S (2014), “Should they have a percutaneous endoscopic gastrostomy? The importance of assessing decision-making capacity and the central role of a multidisciplinary team.” Clinical Medicine 14 (3):245-249

Farrington C, Clare ICH, Holland AJ, Barrett M, & Oborn E (2014), “Knowledge exchange and integrated services: experiences from an integrated community intellectual (learning) disability service for adults” Journal of Intellectual Disability Research DOI: 10.1111/jir.12131

2013

Carroll C, Watson P, Spoudeas HA, Hawkins MM, Walker DA, Clare IC, Holland AJ, Ring HA (2013), “Prevalence, associations, and predictors of apathy in adult survivors of infantile (<5 years of age) posterior fossa brain tumors.” Neuro Oncol 15(4):497-505 Details

Clarke G, Harrison K, Holland A, Kuhn I, Barclay S (2013), “How are Treatment Decisions Made about Artificial Nutrition for Individuals at Risk of Lacking Capacity? A Systematic Literature Review.” PLoS One 8(4):e61475 Details

d'Abrera JC, Holland AJ, Landt J, Stocks-Gee G, Zaman SH (2013), “A neuroimaging proof of principle study of Down's syndrome and dementia: ethical and methodological challenges in intrusive research.” J Intellect Disabil Res 57(2):105-18 Details

de Souza MA, McAllister C, Suttie M, Perrotta C, Mattina T, Faravelli F, Forzano F, Holland A, Hammond P (2013), “Growth hormone, gender and face shape in prader–willi syndrome” American Journal of Medical Genetics Part A 161 (10): 2453–2463

Hempe E-M, Morrison C, Holland A (2013), “Exploring the boundary of a specialist service for adults with intellectual disabilities using a Delphi study: a quantification of stakeholder participation” Health Expectations doi: 10.1111/hex.12107

Holland AJ (2013), “Future challenges for the Journal of Intellectual Disability Research and for research in intellectual disabilities” Journal of Intellectual Disability Research 57 (1):1-2

Larson FV, Whittington J, Webb T, & Holland A J (2013), “A longitudinal follow-up study of people with Prader–Willi syndrome with psychosis and those at increased risk of developing psychosis due to genetic subtype. ” Psychological Medicine DOI: 10.1017/S0033291713002961 .

Lindsay WR, Carson D, Holland AJ, Taylor JL, O'Brien G, Wheeler JR, Steptoe L (2013), “Alcohol and its relationship to offence variables in a cohort of offenders with intellectual disability.” J Intellect Dev Disabil 38(4):325-31 Details

Lindsay WR, Holland AJ, Carson D, Taylor JL, O'Brien G, Steptoe L, Wheeler J (2013), “Responsivity to criminogenic need in forensic intellectual disability services.” J Intellect Disabil Res 57(2):172-81 Details

McAllister CJ, Kelly CL, Manning KE, Holland AJ (2013), “Participant experience of invasive research in adults with intellectual disability.” J Med Ethics Details

Phillips AC, Sleigh A, McAllister CJ, Brage S, Carpenter TA, Kemp GJ, Holland AJ (2013), “Defective Mitochondrial Function In Vivo in Skeletal Muscle in Adults with Down's Syndrome: A (31)P-MRS Study.” PLoS One 8(12):e84031 Details

Wheeler J R, Clare ICH, Holland AJ (2013), “What can social and environmental factors tell us about the risk of offending by people with intellectual disabilities? ” Psychology, Crime & Law DOI:10.1080/1068316X.2013.854789

Wheeler JR, Clare IC, Holland AJ (2013), “Offending by people with intellectual disabilities in community settings: a preliminary examination of contextual factors.” J Appl Res Intellect Disabil 26(5):370-83 Details

Whittington J, Holland AJ (2013), “Traits and Conditions in People with PWS” Prader-Willi Syndrome (Ed.) C Höybe. New York: Nova Biomedical 75-84

Whittington J, Holland AJ (2013), “Behaviour and Psychiatric Conditions in People with PWS” Prader-Willi Syndrome (Ed.) C Höybe. New York: Nova Biomedical 85-94

Whittington J, Holland AJ (2013), “Behaviour and Psychiatric Conditions in People with PWS” Prader-Willi Syndrome: Höybe C (Ed) New York: Nova Biomedical 85-94

Whittington J, Holland AJ (2013), “Traits and Conditions in People with PWS” Prader-Willi Syndrome: Höybe C (Ed). New York: Nova Biomedical 75-84

2012

Ball SL, Panter SG, Redley M, Proctor CA, Byrne K, Clare IC, Holland AJ (2012), “The extent and nature of need for mealtime support among adults with intellectual disabilities.” J Intellect Disabil Res 56(4):382-401 Details

Carson D, Lindsay W R, Holland A J, Taylor J L, O’Brien G, Wheeler JR, Steptoe L, Johnston S (2012), “Sex offenders with intellectual disability referred to levels of community and secure provision: Comparison and prediction of pathway” Legal and Criminological Psychology doi:10.1111/lcrp.12005

Goldstone AP, Holland AJ, Butler JV, Whittington JE (2012), “Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome.” Int J Obes (Lond) 36(12):1564-70 Details

Redley M, Banks C, Foody K, Holland A (2012), “Healthcare for men and women with learning disabilities: understanding inequalities in access” Disability & Society 27 (6):747-759

2011

Hawkins R, Redley M, Holland AJ (2011), “Duty of care and autonomy: how support workers managed the tension between protecting service users from risk and promoting their independence in a specialist group home.” J Intellect Disabil Res 55(9):873-84 Details

Landt J, Ball SL, Holland AJ, Hon J, Owen A, Treppner P, Herbert J (2011), “Age-related changes in plasma dehydroepiandrosterone levels in adults with Down's syndrome and the risk of dementia.” J Neuroendocrinol 23(5):450-5 Details

Phillips AC, Holland AJ (2011), “Assessment of objectively measured physical activity levels in individuals with intellectual disabilities with and without Down's syndrome.” PLoS One 6(12):e28618 Details

Redley M, Clare ICH, Dunn MC, Platten M, Holland, AJ (2011), “Introducing the Mental Capacity Advocate (IMCA) service and the reform of adult safeguarding procedures” British Journal of Social Work 41 (6):1058-1069

Siaperas P, Ring HA, McAllister CJ, Henderson S, Barnett A, Watson P, Holland AJ (2011), “Atypical Movement Performance and Sensory Integration in Asperger's Syndrome.” J Autism Dev Disord Details

Whittington J, Holland A (2011), “Prader-Willi Syndrome” The SAGE Handbook of Developmental Disorders (Eds.) PA Howlin, T Charman, M Ghaziuddin. London: SAGE Publications. 107-123

Whittington J, Holland A (2011), “Prader-Willi Syndrome” The SAGE Handbook of Developmental Disorders: Howlin PA, Charman T, Ghaziuddin M (Eds): London: SAGE Publications 107-123

Whittington J, Holland T (2011), “Recognition of emotion in facial expression by people with Prader-Willi syndrome.” J Intellect Disabil Res 55(1):75-84 Details

2010

Butler JV, Whittington JE, Holland AJ, McAllister CJ, Goldstone AP (2010), “The transition between the phenotypes of Prader-Willi syndrome during infancy and early childhood.” Dev Med Child Neurol 52(6):e88-93 Details

Carson D, Lindsay WR, O’Brien G, Holland AJ, Taylor JL, Wheeler JR, Middleton C, Price K,Steptoe L, Johnston S (2010), “Referrals into services for offenders with intellectual disabilities: Variables predicting community or secure provision” Criminal Behaviour and Mental Health 20: 39-50

Dunn MC, Clare ICH, Holland AJ (2010), “‘Living a life like ours’: support workers’ accounts of substitute decision-making in residential care homes for adults with intellectual disabilities” Journal of Intellectual Disability Research 54 (2): 144-160

Holland AJ (2010), “The model law of Szmukler, Dawson and Daw – the next stage of a long campaign?” Journal of Mental Health Law (Special Issue: A model law fusing incapacity and mental health legislation – is it viable; is it advisable?) (Ed.) G. Richardson. Newcastle: Northumbria Law Press 63-70

Lindsay WR, Carson D, O’Brien G, Holland AJ, Johnston S, Taylor JL, Young S, Steptoe S, Wheeler JR, Middleton C, Price K (2010), “The relationship between assessed risk & service security level for offenders with intellectual disability” Journal of Forensic Psychiatry & Psychology 21: 537-548

Lindsay WR, O’Brien G, Carson D, Holland A J, Taylor JL, Wheeler JR, Middleton C, Price K, Steptoe L, Johnston S (2010), “Pathways into services for offenders with intellectual disabilities: Childhood experiences, diagnostic information, and offense variables” Criminal Justice & Behaviour 37:678-694

O'Brien G, Taylor, JL, Lindsay, WR, Holland AJ, Carson D, Steptoe L, Price K, Middleton C, Wheeler, J (2010), “A multi-centre study of adults with learning disabilities referred to services for antisocial or offending behaviour: demographic, individual, offending and service characteristics” Journal of Learning Disabilities and Offending Behaviour 1 (2): 5-15

Redley M, Clare ICH, Luke L, Holland AJ (2010), “Mental Capacity Act (England & Wales) 2005: The emergent Independent Mental Capacity Advocate (IMCA) service” British Journal of Social Work 40 (6): 1812-1828

Redley M, Hughes JC, Holland AJ (2010), “Voting and mental capacity” BMJ 341: c4085 doi:10.1136/bmj.c.4085

Relkovic D, Doe CM, Humby T, Johnstone KA, Resnick JL, Holland AJ, Hagan JJ, Wilkinson LS, Isles AR (2010), “Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome.” Eur J Neurosci 31(1):156-64 Details

Whittington J, Holland A (2010), “Neurobehavioral phenotype in Prader-Willi syndrome.” Am J Med Genet C Semin Med Genet 154C(4):438-47 Details

2009

Holland A, Whittington J, Cohen O, Curfs L, Delahaye F, Dudley O, Horsthemke B, Lindgren AC, Nourissier C, Sharma N, Vogels A (2009), “The European Prader-Willi Syndrome Clinical Research Database: an aid in the investigation of a rare genetically determined neurodevelopmental disorder.” J Intellect Disabil Res 53(6):538-47 Details

Whittington J, Holland A, Webb T (2009), “Relationship between the IQ of people with Prader-Willi syndrome and that of their siblings: evidence for imprinted gene effects.” J Intellect Disabil Res 53(5):411-8 Details

2008

Ball SL, Holland AJ, Treppner P, Watson PC, Huppert FA (2008), “Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in adults with Down syndrome and mild to moderate learning disabilities.” Br J Clin Psychol 47(Pt 1):1-29 Details

Downes EC, Robson J, Grailly E, Abdel-All Z, Xuereb J, Brayne C, Holland A, Honer WG, Mukaetova-Ladinska EB (2008), “Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals.” Neuropathol Appl Neurobiol 34(1):12-22 Details

Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC, Tauber M, speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS (2008), “Recommendations for the diagnosis and management of Prader-Willi syndrome.” J Clin Endocrinol Metab 93(11):4183-97 Details

Holland T (2008), “Determining priorities in intellectual disability research.” J Intellect Disabil Res 52(Pt 1):1-2 Details

Janicki MP, Henderson CM, Rubin IL, Neurodevelopmental Conditions Study Group (2008), “Neurodevelopmental conditions and aging: report on the Atlanta Study Group Charrette on Neurodevelopmental Conditions and Aging.” Disabil Health J 1(2):116-24 Details

Luke L, Redley M, Clare I, Holland A (2008), “Hospital clinicians' attitudes towards a statutory advocacy service for patients lacking mental capacity: implications for implementation.” J Health Serv Res Policy 13(2):73-8 Details

Reinders H, Holland T (2008), “Special ethics edition of JIDR.” J Intellect Disabil Res 52(7):563 Details

Soni S, Whittington J, Holland AJ, Webb T, Maina EN, Boer H, Clarke D (2008), “The phenomenology and diagnosis of psychiatric illness in people with Prader-Willi syndrome.” Psychol Med 38(10):1505-14 Details

Webb, T., Maina, E.N., Soni, S., Whittington, J., Boer, H., Clarke, D. and Holland, A. (2008), “In search of the psychosis gene in people with Prader-Willi Syndrome. ” American Journal of Medical Genetics 146A:843-853

Whittington JE, Butler JV, Holland AJ (2008), “Pre-, peri- and postnatal complications in Prader-Willi syndrome in a UK sample.” Early Hum Dev 84(5):331-6 Details

2007

Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S (2007), “Gene expression profiling in the adult Down syndrome brain.” Genomics 90(6):647-60 Details

Maina EN, Webb T, Soni S, Whittington J, Boer H, Clarke D, Holland AJ (2007), “Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter” Journal of Human Genetics 52 (4): 297-307

Soni S, Whittington J, Holland AJ, Webb T, Maina E, Boer H, Clarke D (2007), “The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment.” J Intellect Disabil Res 51(Pt 1):32-42 Details

Stansfield AJ, Holland AJ, Clare IC (2007), “The sterilisation of people with intellectual disabilities in England and Wales during the period 1988 to 1999.” J Intellect Disabil Res 51(Pt 8):569-79 Details

Whittington JE, Butler JV, Holland AJ (2007), “Changing rates of genetic subtypes of Prader-Willi syndrome in the UK.” Eur J Hum Genet 15(1):127-30 Details

2006

Ball SL, Holland AJ, Hon J, Huppert FA, Treppner P, Watson PC (2006), “Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.” Int J Geriatr Psychiatry 21(7):661-73 Details

Ball SL, Holland AJ, Huppert F, Treppner P, Dodd K (2006), “The Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and others with Intellectual Disabilities (CAMDEX-DS)” Cambridge University Press ISBN-13 978-0-521-54794-9 and ISBN-10 0-521-54794-6

Hinton EC, Holland AJ, Gellatly MS, Soni S, Owen AM (2006), “An investigation into food preferences and the neural basis of food-related incentive motivation in Prader-Willi syndrome.” J Intellect Disabil Res 50(Pt 9):633-42 Details

Hinton EC, Holland AJ, Gellatly MS, Soni S, Patterson M, Ghatei MA, Owen AM (2006), “Neural representations of hunger and satiety in Prader-Willi syndrome.” Int J Obes (Lond) 30(2):313-21 Details

Hinton, E.C., Holland, A.J., Gellatly, M.S. Soni, S., Patterson, M., Chatei, M.A. and Owen, A.M. (2006), “Functional neuroimaging in Prader-Willi syndrome. Letter to the Editor,” International Journal of Obesity

Webb T, Whittington J, Holland AJ, Soni S, Boer H, Clarke D, Horsthemke B (2006), “CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome.” Clin Genet 69(1):26-32 Details

2005

Oliver C, Holland AJ, Hall S, Crayton L (2005), “Effects of increasing task load on memory impairment in adults with Down’s syndrome” American Journal on Mental Retardation 110(5):330-345

2004

Whittington JE, Holland AJ, Webb T, Butler JV Clarke DJ, Boer H (2004), “Cognitive abilities and genotype in a population-based sample of people with Prader-Willi syndrome” Journal of Intellectual Disability Research 48:172-187

Whittington JE, Holland AJ, Webb T, Butler JV Clarke DJ, Boer H (2004), “Underachievement in Prader Willi Syndrome” Journal of Intellectual Disability Research 48:188-200

Whittington, Joyce and Holland, Tony (2004), “Prader Willi Syndrome Development and Manifestations” Cambridge University Press, Cambridge

2003

Goldstone AP, Brynes AE, Thomas EL, Bell JD, Frost G, Holland A, Bloom, S. (2003), “Body composition using whole body magnetic resonance imaging and resting metabolic rate in Prader-Willi Syndrome adults” Journal of Clinical Endocrinology and Metabolism

Holland A, Whittington J, Hinton E (2003), “The paradox of Prader-Willi syndrome: a genetic model of starvation.” Lancet 362(9388):989-91 Details

Holland AJ, Whittington JE, Butler J, Webb T, Boer H, Clarke DJ (2003), “Behavioural phenotypes associated with specific genetic disorders: evidence from a population-based study of people with Prader-Willi Syndrome” Psychological Medicine 33:141-53

2002

Boer H, Holland AJ, Whittington J, Butler J, Webb T, Clarke D (2002), “Psychotic illness in people with Prader Willi Syndrome due to chromosome 15 maternal uniparental disomy” The Lancet 359: 135-136

Butler J, Whittington JE, Holland AJ, Webb T, Clarke D, Boer H (2002), “Prevalence of, and risk factors for, physical ill-health in people with Prader-Willi syndrome: a population-based study” Developmental Medicine and Child Neurology 44:248-255

Clarke DC, Boer H, Whittington JE, Holland AJ, Butler JV, Webb T (2002), “Prader-Willi Syndrome, compulsive and ritualistic behaviours: The first population-based survey” British Journal of Psychiatry 180: 358-362

Holland AJ, Whittington J, Butler J (2002), “Prader-Willi and Angelman Syndromes: from childhood to adult life” Outcomes in neurodevelopmental and genetic disorders (Eds.) P Howlin, O Udwin. Cambridge University Press, Cambridge

Holland AJ, Whittington J, Butler J (2002), “Prader-Willi and Angelman Syndromes: from childhood to adult life” Outcomes in neurodevelopmental and genetic disorders: Howlin P, Udwin O (Eds). Cambridge University Press, Cambridge

Whittington JE, Holland AJ, Webb T, Butler JV, Clarke DJ, Boer H (2002), “Relationship between clinical and genetic diagnosis of Prader-Willi Syndrome” Journal of Medical Genetics (39):926-32

2001

Goldstone AP, Thomas EL, Bryne AE, Bell JD, Frost G, Saeed N, Hajnal, JV, Howard JK, Holland AJ, Bloom SR (2001), “Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi Syndrome female adults: Evidence for novel influences on body fat distribution” Journal of Clinical Endocrinology and Metabolism 86 (9): 4330-38

Whittington JE, Holland AJ, Webb T, Butler JV, Clarke DJ, Boer H (2001), “Population prevalence and estimated birth incidence and mortality rate for people with Prader Willi Syndrome in one health district” Journal of Medical Genetics 38:792-798

2000

Crayton L, Oliver C, Holland A, Hall S (2000), “Cognitive deterioration in adults with Down’s Syndrome: Effect on the individual, caregivers, and service use” American Journal of Mental Retardation 105 (6): 455-465

Holland AJ (2000), “Down’s Syndrome and Dementia” Dementia, 2nd edn. (Eds.) J O’Brien, D Ames, A Burns. London: Arnold

Holland AJ (2000), “Down’s Syndrome and Dementia” Dementia, 2nd edn: O’Brien J, Ames D, Burns A (Eds). London: Arnold

Holland AJ, Hon J, Huppert FA, Stevens F, Watson P (2000), “Incidence and course of dementia in people with Down’s Syndrome: findings from a population-based study” Journal of Intellectual Disability Research 44 (2): 138-146

1999

Holland AJ, Wong J (1999), “Genetically determined obesity in Prader-Willi Syndrome: The Ethics and Legality of Treatment” Journal of Medical Ethics 25: 230-236

Hon J, Holland AJ, Huppert FA, Watson P (1999), “Neuropsychological assessment of older adults with Down Syndrome: an epidemiological study using the Cambridge Cognitive Examination (CAMCOG)” British Journal of Clinical Psychology 38: 155-165

Rubinzstein D, Hon J, Stevens F, Pyrah L, Tysoe C, Huppert FA, Easton DF, Holland AJ (1999), “ApoE genotype and risk of dementia in Down’s syndrome” Neuropsychiatric Genetics 88b (4):344-347

1998

Crayton L, Oliver C, Holland AJ, Bradbury J, Hall S (1998), “The Neuropsychological assessment of age related cognitive deficits in adults with Down’s Syndrome” Journal of Applied Research in Intellectual Disability 11(3): 255-272

Holland AJ (1998), “Down Syndrome” Mental Retardation, Aging and Dementia (Eds) A Dalton, M Janicki. New York: Taylor and Francis

Holland AJ (1998), “Understanding the eating disorder affecting people with Prader-Willi Syndrome” Journal of Applied Research in Intellectual Disability 11(3): 192-206

Holland AJ (1998), “Down Syndrome” Mental Retardation, Aging and Dementia: Dalton A, Janicki M (Eds). New York: Taylor and Francis

Holland AJ, Hon J, Huppert FA, Stevens F Watson P (1998), “A population-based study of the prevalence and presentation of dementia in adults with Down Syndrome” British Journal of Psychiatry 172: 493-498

Hon J, Huppert FA, Holland AJ, Watson P (1998), “The value of the Rivermead Behavioural Memory Test (Children’s Version) in an epidemiological study of adults with Down’s Syndrome” British Journal of Clinical Psychology 37:15-29

Oliver C, Crayton L, Holland A, Hall S, Bradbury J (1998), “A four year prospective study of age related cognitive change in adults with Down’s Syndrome” Psychological Medicine 28: 1365-1377

1997

Farrer MJ, Crayton L, Davies GE, Oliver C, Powell J, Holland AJ, Kessling AM (1997), “Allelic variablity in D21S11, but not in APP or APOE, is associated with cognitive decline in Down Syndrome” Neuroreport 8:1645-1649

Holland AJ (1997), “The risk of dementia in people with Down’s Syndrome. Research Highlights” Dementia: Challenges and New Directions (Ed.) S Hunter. London: Jessica Kingsley.

Holland AJ (1997), “The risk of dementia in people with Down’s Syndrome. Research Highlights” Dementia: Challenges and New Directions: Hunter (Ed). London: Jessica Kingsley

1995

Holland AJ, Oliver C (1995), “Down’s Syndrome and the links with Alzheimer’s disease” Journal of Neurology, Neurosurgery and Psychiatry 59:111-114

Holland AJ, Treasure J, Coskeran P, Dallow J (1995), “Characteristics of the eating disorder in the Prader-Willi Syndrome: implications for treatment” Journal of Intellectual Disability Research 39(5):373-381

1994

Berg JM, Karlinsky H, Holland AJ (Eds) (1994), “Alzheimer disease Down Syndrome and their relationship” Oxford Medical Publication, Oxford University Press

Holland AJ (1994), “Down's Syndrome and dementia of the Alzheimer type” Dementia. (Eds) A Burns, R Levy. London, Chapman and Hall.

Holland AJ (1994), “Down's Syndrome and Alzheimer's disease” Mental Health and Mental Retardation (Ed.) N Bouras. Cambridge University Press.

Holland AJ (1994), “Down's Syndrome and Alzheimer's disease” Mental Health and Mental Retardation: Bouras N (Ed). Cambridge University Press

Holland AJ (1994), “Down's Syndrome and dementia of the Alzheimer type” Dementia: Burns A, Levy R (Eds). London, Chapman and Hall

Nicholson LB, Wong FS, Ewins DL, Butler J, Holland AJ, Demaine AG, McGregor AM (1994), “Susceptibility to auto-immune thyroiditis in Down's syndrome is associated with the major histocompatibility class II DQA 0301 allele” Clinical Endocrinology 41:381-383

Richards A, Quaghebeur G, Clift S, Holland A, Dahlitz, M, Parkes D (1994), “The upper airway and sleep apnoea in the the Prader-Willi Syndrome” Clinical Otolaryngo¬logy 19: 193-197

Richards S-J, Holland A, Palmer CR (1994), “Increased risk of Alzheimer's disease in mothers of adults with Down's Syndrome” Lancet 344: 1092-1093

1993

Holland AJ, Karlinsky H, Berg JM (1993), “Alzheimer disease in persons with Down syndrome: diagnostic and management considerations” Alzheimer Disease Down Syndrome and their relationship: Berg JM, Karlinsky H, Holland AJ (Eds). Oxford Medical Publication, Oxford University Press

Holland AJ, Karlinsky, H, Berg JM (1993), “Alzheimer disease in persons with Down syndrome: diagnostic and management considerations” Alzheimer Disease Down Syndrome and their relationship. (Eds) JM Berg, H Karlinsky, AJ Holland. Oxford Medical Publication, Oxford University Press.

Holland AJ, Treasure J, Coskeran P, Dallow J, Milton N, Hillhouse E (1993), “Measurement of excessive appetite and metabolic changes in Prader-Willi Syndrome” International Journal of Obesity 17:527-532

1988

Jackson CVE, Holland AJ, Williams CA, Dickerson JWT (1988), “Vitamin E and Alzheimer's disease in subjects with Down's syndrome” J. of Mental Deficiency Research 32: 479-484.

1986

Oliver C, Holland AJ (1986), “Down's Syndrome and Alzheimer's Disease: a Review” Psychological Medicine l6, 307-322