Professor Tony Holland
University position
Professor
Professor Tony Holland is pleased to consider applications from prospective PhD students.
Departments
Home page
http://www.ciddrg.org.uk (personal home page)
Research Themes
Interests
The focus of our interdisciplinary research is on learning disabilities (intellectual disabilities/mental handicap) from different perspectives. Research to date has had the following main themes. First, the relationship between specific genetically determined neurodevelopmental disorders and patterns of development and associated co-morbidities. Research projects have included studies of Prader Willi Syndrome and the associated eating disorder and risks of psychiatric illness; and investigations of the links between Down's syndrome and the high risk for developing Alzheimer's disease. Secondly, studies investigating the interface between people with learning disabilities and the law. This has included research to inform the Mental Capacity Act 2005 and to investigate offending by people with learning disabilies. Thirdly, sociological studies broadly on the theme of 'citizenship' with respect to people with learning disabilities. Since 2008 our group has been part of the NIHR CLAHRC.
Research Focus
Keywordslearning disabilities intellectual disabilities behavioural phenotype mental health |
Clinical conditionsAlzheimer's disease Autism Birth defects Cognitive impairment Dementia Depressive disorders Genetic disorders Learning disabilities |
Equipment
Behavioural analysis
Computerised tomography
Cross-sectional and cohort studies
Electroencephalography (EEG)
Magnetic resonance imaging (MRI)
Neuropsychological testing
Positron Emission Tomography (PET)
Collaborators
CambridgeMarcus Redley |
Key publications
Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using Positron Emission Tomography and Carbon 11-Labeled Pittsburgh Compound B to Image Brain Fibrillar {beta}-Amyloid in Adults With Down Syndrome: Safety, Acceptability, and Feasibility.” Arch Neurol Details
McAllister CJ, Whittington JE, Holland AJ (2011), “Development of the eating behaviour in Prader-Willi Syndrome: advances in our understanding.” Int J Obes (Lond) 35(2):188-97 Details
Ball SL, Holland AJ, Watson PC, Huppert FA (2010), “Theoretical exploration of the neural bases of behavioural disinhibition, apathy and executive dysfunction in preclinical Alzheimer's disease in people with Down's syndrome: potential involvement of multiple frontal-subcortical neuronal circuits.” J Intellect Disabil Res 54(4):320-36 Details
Publications
2013
Carroll C, Watson P, Spoudeas HA, Hawkins MM, Walker DA, Clare IC, Holland AJ, Ring HA (2013), “Prevalence, associations, and predictors of apathy in adult survivors of infantile (<5 years of age) posterior fossa brain tumors.” Neuro Oncol 15(4):497-505 Details
Clarke G, Harrison K, Holland A, Kuhn I, Barclay S (2013), “How are Treatment Decisions Made about Artificial Nutrition for Individuals at Risk of Lacking Capacity? A Systematic Literature Review.” PLoS One 8(4):e61475 Details
d'Abrera JC, Holland AJ, Landt J, Stocks-Gee G, Zaman SH (2013), “A neuroimaging proof of principle study of Down's syndrome and dementia: ethical and methodological challenges in intrusive research.” J Intellect Disabil Res 57(2):105-18 Details
Lindsay WR, Holland AJ, Carson D, Taylor JL, O'Brien G, Steptoe L, Wheeler J (2013), “Responsivity to criminogenic need in forensic intellectual disability services.” J Intellect Disabil Res 57(2):172-81 Details
McAllister CJ, Kelly CL, Manning KE, Holland AJ (2013), “Participant experience of invasive research in adults with intellectual disability.” J Med Ethics Details
2012
Ball SL, Panter SG, Redley M, Proctor CA, Byrne K, Clare IC, Holland AJ (2012), “The extent and nature of need for mealtime support among adults with intellectual disabilities.” J Intellect Disabil Res 56(4):382-401 Details
Goldstone AP, Holland AJ, Butler JV, Whittington JE (2012), “Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome.” Int J Obes (Lond) 36(12):1564-70 Details
2011
Hawkins R, Redley M, Holland AJ (2011), “Duty of care and autonomy: how support workers managed the tension between protecting service users from risk and promoting their independence in a specialist group home.” J Intellect Disabil Res 55(9):873-84 Details
Landt J, Ball SL, Holland AJ, Hon J, Owen A, Treppner P, Herbert J (2011), “Age-related changes in plasma dehydroepiandrosterone levels in adults with Down's syndrome and the risk of dementia.” J Neuroendocrinol 23(5):450-5 Details
Phillips AC, Holland AJ (2011), “Assessment of objectively measured physical activity levels in individuals with intellectual disabilities with and without Down's syndrome.” PLoS One 6(12):e28618 Details
Siaperas P, Ring HA, McAllister CJ, Henderson S, Barnett A, Watson P, Holland AJ (2011), “Atypical Movement Performance and Sensory Integration in Asperger's Syndrome.” J Autism Dev Disord Details
Whittington J, Holland T (2011), “Recognition of emotion in facial expression by people with Prader-Willi syndrome.” J Intellect Disabil Res 55(1):75-84 Details
2010
Butler JV, Whittington JE, Holland AJ, McAllister CJ, Goldstone AP (2010), “The transition between the phenotypes of Prader-Willi syndrome during infancy and early childhood.” Dev Med Child Neurol 52(6):e88-93 Details
Relkovic D, Doe CM, Humby T, Johnstone KA, Resnick JL, Holland AJ, Hagan JJ, Wilkinson LS, Isles AR (2010), “Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome.” Eur J Neurosci 31(1):156-64 Details
Whittington J, Holland A (2010), “Neurobehavioral phenotype in Prader-Willi syndrome.” Am J Med Genet C Semin Med Genet 154C(4):438-47 Details
2009
Holland A, Whittington J, Cohen O, Curfs L, Delahaye F, Dudley O, Horsthemke B, Lindgren AC, Nourissier C, Sharma N, Vogels A (2009), “The European Prader-Willi Syndrome Clinical Research Database: an aid in the investigation of a rare genetically determined neurodevelopmental disorder.” J Intellect Disabil Res 53(6):538-47 Details
Whittington J, Holland A, Webb T (2009), “Relationship between the IQ of people with Prader-Willi syndrome and that of their siblings: evidence for imprinted gene effects.” J Intellect Disabil Res 53(5):411-8 Details
2008
Ball SL, Holland AJ, Treppner P, Watson PC, Huppert FA (2008), “Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in adults with Down syndrome and mild to moderate learning disabilities.” Br J Clin Psychol 47(Pt 1):1-29 Details
Downes EC, Robson J, Grailly E, Abdel-All Z, Xuereb J, Brayne C, Holland A, Honer WG, Mukaetova-Ladinska EB (2008), “Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals.” Neuropathol Appl Neurobiol 34(1):12-22 Details
Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC, Tauber M, speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS (2008), “Recommendations for the diagnosis and management of Prader-Willi syndrome.” J Clin Endocrinol Metab 93(11):4183-97 Details
Holland T (2008), “Determining priorities in intellectual disability research.” J Intellect Disabil Res 52(Pt 1):1-2 Details
Janicki MP, Henderson CM, Rubin IL, Neurodevelopmental Conditions Study Group (2008), “Neurodevelopmental conditions and aging: report on the Atlanta Study Group Charrette on Neurodevelopmental Conditions and Aging.” Disabil Health J 1(2):116-24 Details
Luke L, Redley M, Clare I, Holland A (2008), “Hospital clinicians' attitudes towards a statutory advocacy service for patients lacking mental capacity: implications for implementation.” J Health Serv Res Policy 13(2):73-8 Details
Reinders H, Holland T (2008), “Special ethics edition of JIDR.” J Intellect Disabil Res 52(7):563 Details
Soni S, Whittington J, Holland AJ, Webb T, Maina EN, Boer H, Clarke D (2008), “The phenomenology and diagnosis of psychiatric illness in people with Prader-Willi syndrome.” Psychol Med 38(10):1505-14 Details
Webb, T., Maina, E.N., Soni, S., Whittington, J., Boer, H., Clarke, D. and Holland, A. (2008), “In search of the psychosis gene in people with Prader-Willi Syndrome. ” American Journal of Medical Genetics 146A:843-853
Whittington JE, Butler JV, Holland AJ (2008), “Pre-, peri- and postnatal complications in Prader-Willi syndrome in a UK sample.” Early Hum Dev 84(5):331-6 Details
2007
Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S (2007), “Gene expression profiling in the adult Down syndrome brain.” Genomics 90(6):647-60 Details
Soni S, Whittington J, Holland AJ, Webb T, Maina E, Boer H, Clarke D (2007), “The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment.” J Intellect Disabil Res 51(Pt 1):32-42 Details
Stansfield AJ, Holland AJ, Clare IC (2007), “The sterilisation of people with intellectual disabilities in England and Wales during the period 1988 to 1999.” J Intellect Disabil Res 51(Pt 8):569-79 Details
Whittington JE, Butler JV, Holland AJ (2007), “Changing rates of genetic subtypes of Prader-Willi syndrome in the UK.” Eur J Hum Genet 15(1):127-30 Details
2006
Ball SL, Holland AJ, Hon J, Huppert FA, Treppner P, Watson PC (2006), “Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.” Int J Geriatr Psychiatry 21(7):661-73 Details
Hinton EC, Holland AJ, Gellatly MS, Soni S, Owen AM (2006), “An investigation into food preferences and the neural basis of food-related incentive motivation in Prader-Willi syndrome.” J Intellect Disabil Res 50(Pt 9):633-42 Details
Hinton EC, Holland AJ, Gellatly MS, Soni S, Patterson M, Ghatei MA, Owen AM (2006), “Neural representations of hunger and satiety in Prader-Willi syndrome.” Int J Obes (Lond) 30(2):313-21 Details
Hinton, E.C., Holland, A.J., Gellatly, M.S. Soni, S., Patterson, M., Chatei, M.A. and Owen, A.M. (2006), “Functional neuroimaging in Prader-Willi syndrome. Letter to the Editor,” International Journal of Obesity
Webb T, Whittington J, Holland AJ, Soni S, Boer H, Clarke D, Horsthemke B (2006), “CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome.” Clin Genet 69(1):26-32 Details
2003
Holland A, Whittington J, Hinton E (2003), “The paradox of Prader-Willi syndrome: a genetic model of starvation.” Lancet 362(9388):989-91 Details
Research and Collaboration
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