Miss Sandra Pietsch

University position

Research Assistant

Departments

Department of Physiology, Development and Neuroscience

Home page

http://www.pdn.cam.ac.uk/

Research Theme

Cognitive and Behavioural Neuroscience

Interests

I joined Professor Morton's research group in 2011. Research in the lab aims to understand the mechanisms underlying neurodegeneration and abnormal behaviour in Huntington's disease (HD). I'm focusing on the role of synaptic modulators (specifically Complexins) in neurological disease using various mouse models, including an Complexin overexpressor mouse. Complexin expression levels are altered in Huntington's disease and many other neurological diseases. I am using analytical techniques, such as Western Blot to detect protein expression in different complexin mouse models.

Research Focus

Keywords

Huntington's Disease

Complexin I/II

Behavioural testing

Protein Expression

Clinical conditions

Huntington's disease

Equipment

Behavioural analysis

Immunohistochemistry

Western blotting

Collaborators

No collaborators listed

Associated News Items


    Publications

    2013

    Krishnamurthy D, Harris LW, Levin Y, Koutroukides TA, Rahmoune H, Pietsch S, Vanattou-Saifoudine N, Leweke FM, Guest PC, Bahn S (2013), “Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects.” World J Biol Psychiatry 14(7):478-89 Details

    2012

    Guest PC, Urday S, Ma D, Stelzhammer V, Harris LW, Amess B, Pietsch S, Oheim C, Ozanne SE, Bahn S (2012), “Proteomic analysis of the maternal protein restriction rat model for schizophrenia: identification of translational changes in hormonal signaling pathways and glutamate neurotransmission.” Proteomics 12(23-24):3580-9 Details

    Harris LW, Pietsch S, Cheng TM, Schwarz E, Guest PC, Bahn S (2012), “Comparison of peripheral and central schizophrenia biomarker profiles.” PLoS One 7(10):e46368 Details

    Martins-de-Souza D, Guest PC, Guest FL, Bauder C, Rahmoune H, Pietsch S, Roeber S, Kretzschmar H, Mann D, Baborie A, Bahn S (2012), “Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analyses.” Proteomics 12(3):500-4 Details

    2010

    Wang L, Lockstone HE, Guest PC, Levin Y, Palotás A, Pietsch S, Schwarz E, Rahmoune H, Harris LW, Ma D, Bahn S (2010), “Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia.” J Proteome Res 9(1):521-7 Details

    2009

    Ma D, Chan MK, Lockstone HE, Pietsch SR, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Umrania Y, Guest PC, Levin Y, Maycox PR, Bahn S (2009), “Antipsychotic treatment alters protein expression associated with presynaptic function and nervous system development in rat frontal cortex.” J Proteome Res 8(7):3284-97 Details