HHMI Janelia Research Campus and Medical Research Council Laboratory of Molecular Biology
I am interested in understanding the processing, storage and recall of sensory information using simple model organisms. Currently I am studying olfaction using the genetically tractable fruit fly as a model.
We are making novel genetic tools to manipulate regions of the fly brain at the single-cell level during behaviour. We also use high-resolution microscopy and computational image analysis to generate detailed anatomical maps of the olfactory system, testing hypotheses using optophysiology.
Using these techniques we hope to understand how innate and learned olfactory behaviours are generated and interact in a 'simple' brain.
My work is funded by the Cambridge Trust, Medical Research Council, Boehringer Ingelheim Fonds and the Howard Hughes Medical Institute.
Associated News Items
Kohl J, Ng J, Cachero S, Ciabatti E, Dolan MJ, Sutcliffe B, Tozer A, Ruehle S, Krueger D, Frechter S, Branco T, Tripodi M, Jefferis GS (2014), “Ultrafast tissue staining with chemical tags.” Proc Natl Acad Sci U S A 111(36):E3805-14 Details
Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP (2013), “CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.” Dev Cell 26(3):223-36 Details
Burns JG, Svetec N, Rowe L, Mery F, Dolan MJ, Boyce WT, Sokolowski MB (2012), “Gene-environment interplay in Drosophila melanogaster: chronic food deprivation in early life affects adult exploratory and fitness traits.” Proc Natl Acad Sci U S A 109 Suppl 2:17239-44 Details