Michael-John Dolan

Michael-John Dolan

University position

PhD student
Supervised by Gregory Jefferis

Institutes

HHMI Janelia Research Campus and Medical Research Council Laboratory of Molecular Biology

Email

mjd203@cam.ac.uk

Research Themes

Systems and Computational Neuroscience

Cellular and Molecular Neuroscience

Interests

I am interested in understanding the processing, storage and recall of sensory information using simple model organisms. Currently I am studying olfaction using the genetically tractable fruit fly as a model.

We are making novel genetic tools to manipulate regions of the fly brain at the single-cell level during behaviour. We also use high-resolution microscopy and computational image analysis to generate detailed anatomical maps of the olfactory system, testing hypotheses using optophysiology.

Using these techniques we hope to understand how innate and learned olfactory behaviours are generated and interact in a 'simple' brain.

My work is funded by the Cambridge Trust, Medical Research Council, Boehringer Ingelheim Fonds and the Howard Hughes Medical Institute.

Research Focus

Keywords

Neurogenetics

Learning

Optogenetics

Innate

Olfaction

Clinical conditions

No direct clinical relevance

Equipment

Behavioural analysis

Calcium imaging

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Collaborators

Cambridge

Cahir O'Kane

International

Karla Kaun Web: http://www.kaunlab.com/

Thomas Preat Web: http://www.gdsm.espci.fr/spip.ph...

Gerald Rubin Web: http://janelia.org/lab/rub...

Benjamin White Web: http://neuroscience.nih.gov/Lab.asp...

Associated News Items


    Publications

    2014

    Kohl J, Ng J, Cachero S, Ciabatti E, Dolan MJ, Sutcliffe B, Tozer A, Ruehle S, Krueger D, Frechter S, Branco T, Tripodi M, Jefferis GS (2014), “Ultrafast tissue staining with chemical tags.” Proc Natl Acad Sci U S A 111(36):E3805-14 Details

    2013

    Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP (2013), “CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.” Dev Cell 26(3):223-36 Details

    2012

    Burns JG, Svetec N, Rowe L, Mery F, Dolan MJ, Boyce WT, Sokolowski MB (2012), “Gene-environment interplay in Drosophila melanogaster: chronic food deprivation in early life affects adult exploratory and fitness traits.” Proc Natl Acad Sci U S A 109 Suppl 2:17239-44 Details