Dr Marco Brancaccio


Cellular and molecular basis of circadian clocks in the suprachiasmatic nucleus

Research Focus






Clinical conditions

No direct clinical relevance


Calcium imaging

Lentiviral vectors, AAV vectors


Organotypic cell culture

Video time lapse live imaging


No collaborators listed

Associated News Items

Key publications

Brancaccio M, Patton AP, Chesham JE, Maywood ES, Hastings MH. (2017), “Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.” Neuron Mar 22;93(6):1420-1435

Brancaccio M, Maywood ES, Chesham JE, Loudon AS, Hastings MH (2013), “A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus.” Neuron 78(4):714-28 Details



Edwards MD, Brancaccio M, Chesham JE, Maywood ES, Hastings MH (2016), “Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling” Proc Natl Acad Sci U S A Mar 8;113(10):2732-7

Feeney KA, Putker M, Brancaccio M, O'Neill JS. (2016), “In-depth Characterization of Firefly Luciferase as a Reporter of Circadian Gene Expression in Mammalian Cells.” J Biol Rhythms Dec;31(6):540-550


Parsons MJ, Brancaccio M, Sethi S, Maywood ES, Satija R, Edwards JK, Jagannath A, Couch Y, Finelli MJ, Smyllie NJ, Esapa C, Butler R, Barnard AR, Chesham JE, Saito S, Joynson G, Wells S, Foster RG, Oliver PL, Simon MM, Mallon AM, Hastings MH, Nolan PM (2015), “The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.” Cell 162(3):607-21 Details


Brancaccio M, Enoki R, Mazuski CN, Jones J, Evans JA, Azzi A (2014), “Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.” J Neurosci 34(46):15192-9 Details

Hastings MH, Brancaccio M, Maywood ES (2014), “Circadian pacemaking in cells and circuits of the suprachiasmatic nucleus.” J Neuroendocrinol 26(1):2-10 Details


Maywood ES, Drynan L, Chesham JE, Edwards MD, Dardente H, Fustin JM, Hazlerigg DG, O'Neill JS, Codner GF, Smyllie NJ, Brancaccio M, Hastings MH (2013), “Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse.” Proc Natl Acad Sci U S A 110(23):9547-52 Details


Brancaccio M, Pivetta C, Granzotto M, Filippis C, Mallamaci A (2010), “Emx2 and Foxg1 inhibit gliogenesis and promote neuronogenesis.” Stem Cells 28(7):1206-18 Details