Dr Liora Vilmovsky

Interests

I aim to study the transcriptomics of neurons (both populations and single cell) in the dorsomedial division of the ventromedial hypothalamus (VMH) and the ventrolateral division in order to understand their cellular diversity and plasticity and, ultimately, how they are able to support diverse innate behaviors. My work would: 1) provide a catalog of cell-types in VMH on which to base further studies, 2) identify gene products that contribute to their functional diversity and plasticity, and 3) understand how experience can modify this diversity to adapt behaviour responses to the environment. This knowledge will be important to understand how the same brain structure can control both fear and aggression and sex, and could be important to understand how these innate behaviors may become intertwined under pathological situations.

Research Focus

Keywords

RNA-seq

Behavior

Molecular Biology

ventromedial hypothalamus

Clinical conditions

Anxiety disorders

Equipment

No equipment indicated

Collaborators

International

Cornelius Gross Web: http://www.embl.it/researc...

Associated News Items


    Publications

    2014

    Mahata B, Zhang X, Kolodziejczyk AA, Proserpio V, Haim-Vilmovsky L, Taylor AE, Hebenstreit D, Dingler FA, Moignard V, Gƶttgens B, Arlt W, McKenzie AN, Teichmann SA (2014), “Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.” Cell Rep 7(4):1130-42 Details

    2013

    Kraut-Cohen J, Afanasieva E, Haim-Vilmovsky L, Slobodin B, Yosef I, Bibi E, Gerst JE (2013), “Translation- and SRP-independent mRNA targeting to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae.” Mol Biol Cell 24(19):3069-84 Details

    2011

    Gadir N, Haim-Vilmovsky L, Kraut-Cohen J, Gerst JE (2011), “Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae.” RNA 17(8):1551-65 Details

    Haim-Vilmovsky L, Gadir N, Herbst RH, Gerst JE (2011), “A genomic integration method for the simultaneous visualization of endogenous mRNAs and their translation products in living yeast.” RNA 17(12):2249-55 Details

    Haim-Vilmovsky L, Gerst JE (2011), “Visualizing endogenous mRNAs in living yeast using m-TAG, a PCR-based RNA aptamer integration method, and fluorescence microscopy.” Methods Mol Biol 714:237-47 Details

    2009

    Haim-Vilmovsky L, Gerst JE (2009), “m-TAG: a PCR-based genomic integration method to visualize the localization of specific endogenous mRNAs in vivo in yeast.” Nat Protoc 4(9):1274-84 Details

    Zipor G, Haim-Vilmovsky L, Gelin-Licht R, Gadir N, Brocard C, Gerst JE (2009), “Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae.” Proc Natl Acad Sci U S A 106(47):19848-53 Details

    2007

    Aronov S, Gelin-Licht R, Zipor G, Haim L, Safran E, Gerst JE (2007), “mRNAs encoding polarity and exocytosis factors are cotransported with the cortical endoplasmic reticulum to the incipient bud in Saccharomyces cerevisiae.” Mol Cell Biol 27(9):3441-55 Details

    Feldmesser E, Bercovich D, Avidan N, Halbertal S, Haim L, Gross-Isseroff R, Goshen S, Lancet D (2007), “Mutations in olfactory signal transduction genes are not a major cause of human congenital general anosmia.” Chem Senses 32(1):21-30 Details

    Haim L, Zipor G, Aronov S, Gerst JE (2007), “A genomic integration method to visualize localization of endogenous mRNAs in living yeast.” Nat Methods 4(5):409-12 Details