Dr Hugh Matthews

Hugh Matthews

University position

Reader

Dr Hugh Matthews is pleased to consider applications from prospective PhD students.

Departments

Department of Physiology, Development and Neuroscience

Email

hrm1@cam.ac.uk

Home page

http://www.pdn.cam.ac.uk/staff/m... (personal home page)

Research Theme

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

Phototransduction and olfactory transduction. Calcium homeostasis in vertebrate photoreceptors and olfactory receptors, and its role in modulating their electrical responses to stimulation. Light-induced calcium release within the photoreceptor outer segment. Mechanisms of response termination in cone photoreceptors. Mechanisms for calcium extrusion in vertebrate olfactory receptors.

Pseudo-colour image of salamander rod photoreceptor during simultaneous recording of electrical response and calcium dye fluorescence during stimulation by a bar of light
Pseudo-colour image of salamander rod photoreceptor during simultaneous recording of electrical response and calcium dye fluorescence during stimulation by a bar of light
Click image to view full-size

Research Focus

Keywords

phototransduction

olfactory transduction

calcium

sensory adaptation

light adaptation

Clinical conditions

No direct clinical relevance

Equipment

Calcium imaging

Electrophysiological recording techniques

Whole cell patch clamp

Collaborators

International

Carter Cornwall Web: http://biophysics.bumc.bu.edu/faculty...

Rosalie Crouch Web: http://www.musc.edu/neurosc...

Gordon Fain Web: http://www.physci.ucla.edu/researc...

Johannes Reisert Web: http://www.monell.org/faculty...

Alapakkam Sampath Web: http://www.usc.edu/program...

Key publications

Antolin S, Reisert J, Matthews HR (2010), “Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia.” J Gen Physiol 135(4):367-78 Details

Matthews HR, Sampath AP (2010), “Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.” J Gen Physiol 135(4):355-66 Details

Antolin S, Matthews HR (2007), “The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells.” J Physiol 581(Pt 2):495-503 Details

Leung YT, Fain GL, Matthews HR (2007), “Simultaneous measurement of current and calcium in the ultraviolet-sensitive cones of zebrafish” Journal of Physiology 579:15-27 Details

Matthews HR, Fain GL (2003), “The effect of light on outer segment calcium in salamander rods” Journal of Physiology 552:763-776