Dr Hugh Matthews
Dr Hugh Matthews is pleased to consider applications from prospective PhD students.
http://www.pdn.cam.ac.uk/staff/m... (personal home page)
Phototransduction and olfactory transduction. Calcium homeostasis in vertebrate photoreceptors and olfactory receptors, and its role in modulating their electrical responses to stimulation. Light-induced calcium release within the photoreceptor outer segment. Mechanisms of response termination in cone photoreceptors. Mechanisms for calcium extrusion in vertebrate olfactory receptors.
No direct clinical relevance
Electrophysiological recording techniques
Whole cell patch clamp
Carter Cornwall Web: http://biophysics.bumc.bu.edu/faculty...
Rosalie Crouch Web: http://www.musc.edu/neurosc...
Gordon Fain Web: http://www.physci.ucla.edu/researc...
Johannes Reisert Web: http://www.monell.org/faculty...
Alapakkam Sampath Web: http://www.usc.edu/program...
Antolin S, Reisert J, Matthews HR (2010), “Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia.” J Gen Physiol 135(4):367-78 Details
Matthews HR, Sampath AP (2010), “Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.” J Gen Physiol 135(4):355-66 Details
Antolin S, Matthews HR (2007), “The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells.” J Physiol 581(Pt 2):495-503 Details
Leung YT, Fain GL, Matthews HR (2007), “Simultaneous measurement of current and calcium in the ultraviolet-sensitive cones of zebrafish” Journal of Physiology 579:15-27 Details
Matthews HR, Fain GL (2003), “The effect of light on outer segment calcium in salamander rods” Journal of Physiology 552:763-776