Dr Golam Khandaker

Golam Khandaker

University position

Wellcome Trust Clinical Research Fellow and PhD Student

Departments

Department of Psychiatry

Institutes

Cambridge Institute for Medical Research (CIMR)

Home page

http://www.psychiatry.cam.ac.uk/researc...

Research Themes

Clinical and Veterinary Neuroscience

Cognitive and Behavioural Neuroscience

The Cambridge Neuroscience Community

Interests

I am a psychiatrist and clinical epidemiologist interested in early life risk factors, neurodevelopment and adult neuropsychiatric disorders (schizophrenia and depression); and common links in childhood between chronic adult diseases, physical and neuropsychiatric.

Schizophrenia and depression are characterised by mental phenomena but are also known to be associated with immunological and metabolic abnormalities. It has been proposed that these may contribute to causation of these neuropsychiatric disorders, and that there may be causes in common with chronic physical illnesses without obvious psychiatric components such as obesity and cardiovascular disease.

I am working with a prospective birth cohort of over 10,000 individuals born in Bristol area in South-West England in the early 1990s (ALSPAC). I aim to explore effects of early life infection, immune and metabolic dysfunction on childhood neurocognitive development, and risk of psychotic and depressive symptoms.

Premorbid IQ and risk of adult schizhophrenia
Premorbid IQ and risk of adult schizophrenia
Click image to view full-size

Research Focus

Keywords

Schizophrenia

Depression

Neurodevelopment and cognition

Inflammation and immunity

Clinical epidemiology

Clinical conditions

Childhood disorders

Cognitive impairment

Depressive disorders

Encephalitis

Meningitis

Schizophrenia

Equipment

Behavioural analysis

Clinical/ diagnostic psychiatric instruments

Computational modelling

Cross-sectional and cohort studies

Enzyme assays

Life course epidemiology

Neuropsychological testing

Collaborators

Cambridge

Jenny Barnett

Daniel Jackson

Ian White

United Kingdom

ALSPAC birth cohort Web: http://www.bristol.ac.uk/alspac/

Glyn Lewis Web: http://www.bristol.ac.uk/psychia...

Stan Zammit Web: http://www.bristol.ac.uk/psychia...

Key publications

Khandaker GM, Barnett JH, White IR, Jones PB (2011), “A quantitative meta-analysis of population-based studies of premorbid intelligence and schizophrenia.” Schizophr Res 132(2-3):220-7 Details

Khandaker GM, Jones PB (2011), “Cognitive and functional impairment after severe sepsis.” JAMA 305(7):673-4; author reply 674 Details

Publications

2012

Khandaker GM, Dibben CR, Jones PB (2012), “Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring?” Obes Rev 13(6):518-27 Details

Khandaker GM, Gandamaneni PK, Dibben CR, Cherukuru S, Cairns P, Ray MK (2012), “Evaluating care pathways for community psychiatry in England: a qualitative study.” J Eval Clin Pract Details

Khandaker GM, Kirkbride JB, Jones PB (2012), “Epidemiological challenges in systematic reviews.” Br J Psychiatry 201(3):248 Details

Khandaker GM, Zimbron J, Dalman C, Lewis G, Jones PB (2012), “Childhood infection and adult schizophrenia: a meta-analysis of population-based studies.” Schizophr Res 139(1-3):161-8 Details

Khandaker GM, Zimbron J, Lewis G, Jones PB (2012), “Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies.” Psychol Med :1-19 Details

Zimbrón J, Ruiz de Azúa S, Khandaker GM, Gandamaneni PK, Crane CM, González-Pinto A, Stochl J, Jones PB, Pérez J (2012), “Clinical and sociodemographic comparison of people at high-risk for psychosis and with first-episode psychosis.” Acta Psychiatr Scand Details

2010

Khandaker GM, Khandaker GM, Dibben C, Zurynski Y, Elliott EJ, Booy R (2010), “Mania in a patient with H1N1: is oseltamivir the culprit or a red herring?” Am J Psychiatry 167(9):1129-30; author reply 1130 Details

2009

Dibben C, Khandaker G, Ramana R (2009), “Aftercare under Section 117 of the Mental Health Act 1983: awareness and practice.” Med Sci Law 49(1):41-5 Details

Khandaker GM, Cherukuru S, Dibben C, Ray MK. (2009), “From sector-based to a functional model: a qualitative study of staff perception” The Psychiatrist (Formerly Psychiatric Bulletin) 33: 329- 332

2008

Dibben C, Saeed H, Stagias K, Khandaker GM, Rubinsztein J. (2008), “Impact of a Crisis Resolution and Home Treatment Team (CRHTT) for older people with mental illness” The Psychiatrist (Formerly Psychiatric Bulletin) 32: 268-270