Dr Golam Khandaker

Golam Khandaker

University position

Wellcome Trust Intermediate Clinical Fellow

Dr Golam Khandaker is pleased to consider applications from prospective PhD students.


Department of Psychiatry


Behavioural and Clinical Neuroscience Institute



Research Themes

Cognitive and Behavioural Neuroscience

Clinical and Veterinary Neuroscience


Working at the interface between immunology and psychiatry, my research examines novel immunological mechanism and treatment for major psychiatric disorders such as depression and schizophrenia using epidemiological, genetic and treatment studies.

I am particularly interested in the role of inflammation (cytokines, genes and peripheral immune cells). I use population-based epidemiological and genetic studies to examine causality and to identify novel targets for intervention. My research includes use of immune and behavioural phenotyping to delineate novel sub-types of psychiatric disorders, and clinical trials to examine the effect of immune-modulating drugs on mood, psychosis and cognition in patients with major psychiatric disorders.

The aim of the work is to identify novel mechanisms and treatments for major psychiatric disorders that affect one in four people in their lifetime, but many of those affected do not respond to currently available treatments.

Figure 1: Depression and Psychosis at Age 18 Years by Tertiles of IL-6 at Age 9 Years in the ALSPAC Cohort
Figure 1: Depression and Psychosis at Age 18 Years by Tertiles of IL-6 at Age 9 Years in the ALSPAC Cohort
Click image to view full-size

Research Focus







Clinical conditions

Anxiety disorders

Bipolar disorder

Depressive disorders



Behavioural analysis

Computational modelling

Cross-sectional and cohort studies

Cytokine Assay

Gene Expression


Mendelian Randomisation

Randomised control trials



Stephen Burgess

Alasdair Coles

Peter Jones

United Kingdom

ALSPAC Birth Cohort Web: http://www.bristol.ac.uk/alspac/

Glyn Lewis Web: https://iris.ucl.ac.uk/iris/br...

Stan Zammit Web: http://www.bris.ac.uk/social-...


Christina Dalman Web: http://ki.se/en/peop...

Robert Dantzer Web: http://faculty.mdanderson.org/Robert_...

Associated News Items

Key publications

Khandaker GM, Pearson RM, Zammit S, Lewis G, Jones PB (2014), “Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life: A Population-Based Longitudinal Study.” JAMA Psychiatry Details

Khandaker GM, Barnett JH, White IR, Jones PB (2011), “A quantitative meta-analysis of population-based studies of premorbid intelligence and schizophrenia.” Schizophr Res 132(2-3):220-7 Details



Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2014), “A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence.” Psychol Med :1-10 Details

Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2014), “Childhood Epstein-Barr Virus infection and subsequent risk of psychotic experiences in adolescence: A population-based prospective serological study.” Schizophr Res 158(1-3):19-24 Details

Khandaker GM, Zammit S, Lewis G, Jones PB (2014), “A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence.” Schizophr Res 152(1):139-45 Details


Khandaker GM, Gandamaneni PK, Dibben CR, Cherukuru S, Cairns P, Ray MK (2013), “Evaluating care pathways for community psychiatry in England: a qualitative study.” J Eval Clin Pract 19(2):298-303 Details

Khandaker GM, Zimbron J, Lewis G, Jones PB (2013), “Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies.” Psychol Med 43(2):239-57 Details

Zimbrón J, Ruiz de Azúa S, Khandaker GM, Gandamaneni PK, Crane CM, González-Pinto A, Stochl J, Jones PB, Pérez J (2013), “Clinical and sociodemographic comparison of people at high-risk for psychosis and with first-episode psychosis.” Acta Psychiatr Scand 127(3):210-6 Details


Khandaker GM, Dibben CR, Jones PB (2012), “Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring?” Obes Rev 13(6):518-27 Details

Khandaker GM, Kirkbride JB, Jones PB (2012), “Epidemiological challenges in systematic reviews.” Br J Psychiatry 201(3):248 Details

Khandaker GM, Zimbron J, Dalman C, Lewis G, Jones PB (2012), “Childhood infection and adult schizophrenia: a meta-analysis of population-based studies.” Schizophr Res 139(1-3):161-8 Details


Khandaker GM, Jones PB (2011), “Cognitive and functional impairment after severe sepsis.” JAMA 305(7):673-4; author reply 674 Details


Khandaker GM, Khandaker GM, Dibben C, Zurynski Y, Elliott EJ, Booy R (2010), “Mania in a patient with H1N1: is oseltamivir the culprit or a red herring?” Am J Psychiatry 167(9):1129-30; author reply 1130 Details


Dibben C, Khandaker G, Ramana R (2009), “Aftercare under Section 117 of the Mental Health Act 1983: awareness and practice.” Med Sci Law 49(1):41-5 Details

Khandaker GM, Cherukuru S, Dibben C, Ray MK. (2009), “From sector-based to a functional model: a qualitative study of staff perception” The Psychiatrist (Formerly Psychiatric Bulletin) 33: 329- 332


Dibben C, Saeed H, Stagias K, Khandaker GM, Rubinsztein J. (2008), “Impact of a Crisis Resolution and Home Treatment Team (CRHTT) for older people with mental illness” The Psychiatrist (Formerly Psychiatric Bulletin) 32: 268-270