Dr Shahar Frechter

Interests

I am using Drosophila olfaction as a model system to understand how sensory information is processed and transformed into behavior. I have focused on the Lateral Horn of Drosophila, which appears to be required for innate olfactory behavior. Earlier results show segregation of food and pheromone representation in the LH, which suggests that the LH is organized according to biological values of olfactory input. I am combining genetic labelling of specific groups of neurons with targeted in vivo whole cell patch clamp recording and neuroanatomy to study information processing in the lateral horn of Drosophila.

Research Focus

Keywords

Drosophila

Lateral Horn

Olfaction

electrophysiology

Clinical conditions

No direct clinical relevance

Equipment

Confocal microscopy

Immunohistochemistry

Whole cell patch clamp

Collaborators

No collaborators listed

Associated News Items


    Publications

    2014

    Amor V, Feinberg K, Eshed-Eisenbach Y, Vainshtein A, Frechter S, Grumet M, Rosenbluth J, Peles E (2014), “Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM.” J Neurosci 34(15):5089-98 Details

    2013

    Golan N, Kartvelishvily E, Spiegel I, Salomon D, Sabanay H, Rechav K, Vainshtein A, Frechter S, Maik-Rachline G, Eshed-Eisenbach Y, Momoi T, Peles E (2013), “Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy.” J Neurosci 33(27):10950-61 Details

    Kohl J, Ostrovsky AD, Frechter S, Jefferis GS (2013), “A bidirectional circuit switch reroutes pheromone signals in male and female brains.” Cell 155(7):1610-23 Details

    2012

    Ivanovic A, Horresh I, Golan N, Spiegel I, Sabanay H, Frechter S, Ohno S, Terada N, Möbius W, Rosenbluth J, Brose N, Peles E (2012), “The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.” J Cell Biol 196(3):337-44 Details

    2011

    Novak N, Bar V, Sabanay H, Frechter S, Jaegle M, Snapper SB, Meijer D, Peles E (2011), “N-WASP is required for membrane wrapping and myelination by Schwann cells.” J Cell Biol 192(2):243-50 Details

    2010

    Feinberg K, Eshed-Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, Dupree JL, Grumet M, Brophy PJ, Shrager P, Peles E (2010), “A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.” Neuron 65(4):490-502 Details

    2007

    Frechter S, Elia N, Tzarfaty V, Selinger Z, Minke B (2007), “Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptors.” J Neurosci 27(21):5571-83 Details

    2006

    Frechter S, Minke B (2006), “Light-regulated translocation of signaling proteins in Drosophila photoreceptors.” J Physiol Paris 99(2-3):133-9 Details

    Meyer NE, Joel-Almagor T, Frechter S, Minke B, Huber A (2006), “Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade.” J Cell Sci 119(Pt 12):2592-603 Details

    2005

    Elia N, Frechter S, Gedi Y, Minke B, Selinger Z (2005), “Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors.” J Cell Biol 171(3):517-26 Details

    2004

    Agam K, Frechter S, Minke B (2004), “Activation of the Drosophila TRP and TRPL channels requires both Ca2+ and protein dephosphorylation.” Cell Calcium 35(2):87-105 Details

    2002

    Bähner M, Frechter S, Da Silva N, Minke B, Paulsen R, Huber A (2002), “Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current.” Neuron 34(1):83-93 Details