Dr Fabian Grabenhorst

Interests

My research focuses on the brain mechanisms for reward and economic decision making using neurophysiology and functional MRI. Specific areas of investigation include the neural computation of economic values and choices; the neural processing of sensory and hedonic aspects of food rewards including oral fat texture, odor, taste, and temperature; how labels influence both food choice and neural coding of food taste benefits and health costs; and the functions of the orbitofrontal and ventromedial prefrontal cortex, the amygdala, and related reward systems.

Research Focus

Keywords

Reward

Decision-making

Food

Orbitofrontal cortex

Amygdala

Clinical conditions

Addiction

Eating disorders

Obesity

Equipment

Behavioural analysis

Electrophysiological recording techniques

Magnetic resonance imaging (MRI)

Collaborators

Cambridge

Raymundo Baez Mendoza

Wolfram Schultz

Associated News Items


    Key publications

    Grabenhorst F*, Hernadi I*, Schultz W. (2016), “Amygdala neurons evaluate the progress of self-defined economic choice sequences.” Elife Oct 12;5. pii: e18731. doi: 10.7554/eLife.18731.

    Tsutsui K*, Grabenhorst F*, Kobayashi S, Schultz W. *Equal contributions (2016), “A dynamic code for economic object valuation in prefrontal cortex neurons” Nature Communications Sep 13;7:12554. doi: 10.1038/ncomms12554.

    Zangemeister L, Grabenhorst F, Schultz W. (2016), “Neural Basis for Economic Saving Strategies in Human Amygdala-Prefrontal Reward Circuits” Curren Biology Nov 21;26(22):3004-3013. doi: 10.1016/j.cub.2016.09.016.

    HernĂ¡di I, Grabenhorst F, Schultz W (2015), “Planning activity for internally generated reward goals in monkey amygdala neurons.” Nat Neurosci 18(3):461-469 Details

    Grabenhorst F (in press), “Brain systems for the pleasure of food and other primary rewards” Anhedonia: A Comprehensive Handbook Volume I (ed. M. Ritsner) (Springer)

    Grabenhorst F, Rolls ET (2013), “The representation of oral fat texture in the human somatosensory cortex.” Hum Brain Mapp Details

    Grabenhorst F, Schulte FP, Maderwald S, Brand M (2013), “Food labels promote healthy choices by a decision bias in the amygdala.” Neuroimage 74:152-63 Details

    Grabenhorst F, HernĂ¡di I, Schultz W (2012), “Prediction of economic choice by primate amygdala neurons.” Proc Natl Acad Sci U S A Details

    Grabenhorst F, Rolls ET (2011), “Value, pleasure and choice in the ventral prefrontal cortex.” Trends Cogn Sci 15(2):56-67 Details

    Grabenhorst F, Rolls ET, Margot C (2011), “A hedonically complex odor mixture produces an attentional capture effect in the brain.” Neuroimage 55(2):832-43 Details

    Grabenhorst F, D'Souza AA, Parris BA, Rolls ET, Passingham RE (2010), “A common neural scale for the subjective pleasantness of different primary rewards.” Neuroimage 51(3):1265-74 Details

    Grabenhorst F, Rolls ET, Parris BA, d'Souza AA (2010), “How the brain represents the reward value of fat in the mouth.” Cereb Cortex 20(5):1082-91 Details

    Grabenhorst F, Rolls ET, Bilderbeck A (2008), “How cognition modulates affective responses to taste and flavor: top-down influences on the orbitofrontal and pregenual cingulate cortices.” Cereb Cortex 18(7):1549-59 Details

    Grabenhorst F, Rolls ET, Margot C, da Silva MA, Velazco MI (2007), “How pleasant and unpleasant stimuli combine in different brain regions: odor mixtures.” J Neurosci 27(49):13532-40 Details

    Publications

    2013

    Luo Q, Ge T, Grabenhorst F, Feng J, Rolls ET (2013), “Attention-dependent modulation of cortical taste circuits revealed by granger causality with signal-dependent noise.” PLoS Comput Biol 9(10):e1003265 Details

    2012

    Ge T, Feng J, Grabenhorst F, Rolls ET (2012), “Componential Granger causality, and its application to identifying the source and mechanisms of the top-down biased activation that controls attention to affective vs sensory processing.” Neuroimage 59(2):1846-58 Details

    2010

    Grabenhorst F, Rolls ET (2010), “Attentional modulation of affective versus sensory processing: functional connectivity and a top-down biased activation theory of selective attention.” J Neurophysiol 104(3):1649-60 Details

    Rolls ET, Grabenhorst F, Deco G (2010), “Decision-making, errors, and confidence in the brain.” J Neurophysiol 104(5):2359-74 Details

    Rolls ET, Grabenhorst F, Deco G (2010), “Choice, difficulty, and confidence in the brain.” Neuroimage 53(2):694-706 Details

    Rolls ET, Grabenhorst F, Parris BA (2010), “Neural systems underlying decisions about affective odors.” J Cogn Neurosci 22(5):1069-82 Details

    2009

    Grabenhorst F, Rolls ET (2009), “Different representations of relative and absolute subjective value in the human brain.” Neuroimage 48(1):258-68 Details

    Rolls ET, Grabenhorst F, Franco L (2009), “Prediction of subjective affective state from brain activations.” J Neurophysiol 101(3):1294-308 Details

    2008

    Grabenhorst F, Rolls ET (2008), “Selective attention to affective value alters how the brain processes taste stimuli.” Eur J Neurosci 27(3):723-9 Details

    Grabenhorst F, Rolls ET, Parris BA (2008), “From affective value to decision-making in the prefrontal cortex.” Eur J Neurosci 28(9):1930-9 Details

    Rolls ET, Grabenhorst F (2008), “The orbitofrontal cortex and beyond: from affect to decision-making.” Prog Neurobiol 86(3):216-44 Details

    Rolls ET, Grabenhorst F, Margot C, da Silva MA, Velazco MI (2008), “Selective attention to affective value alters how the brain processes olfactory stimuli.” J Cogn Neurosci 20(10):1815-26 Details

    Rolls ET, Grabenhorst F, Parris BA (2008), “Warm pleasant feelings in the brain.” Neuroimage 41(4):1504-13 Details

    2007

    Brand M, Grabenhorst F, Starcke K, Vandekerckhove MM, Markowitsch HJ (2007), “Role of the amygdala in decisions under ambiguity and decisions under risk: evidence from patients with Urbach-Wiethe disease.” Neuropsychologia 45(6):1305-17 Details

    Brand M, Recknor EC, Grabenhorst F, Bechara A (2007), “Decisions under ambiguity and decisions under risk: correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules.” J Clin Exp Neuropsychol 29(1):86-99 Details

    Guest S, Grabenhorst F, Essick G, Chen Y, Young M, McGlone F, de Araujo I, Rolls ET (2007), “Human cortical representation of oral temperature.” Physiol Behav 92(5):975-84 Details

    Kalbe E, Grabenhorst F, Brand M, Kessler J, Hilker R, Markowitsch HJ (2007), “Elevated emotional reactivity in affective but not cognitive components of theory of mind: a psychophysiological study.” J Neuropsychol 1(Pt 1):27-38 Details