I am interested in the neurobiological underpinnings of autism spectrum conditions (ASC) with special focus on cerebral lateralization and functional connectivity. During my PhD I investigated atypical hemispheric specialisation in ASC at different levels of brain organization both in terms of structure and function. I further examined whether atypical patterns of handedness, cortical and functional asymmetries differentiate individuals with ASC with distinct symptom profiles and might thus be an indicator of different subtypes within the autism spectrum.
Magnetic resonance imaging (MRI)
Associated News Items
Floris DL, Barber AD, Nebel MB, Martinelli M, Lai MC, Crocetti D, Baron-Cohen S, John Suckling J, Pekar JJ and Mostofsky SH (2016), “Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits” Molecular Autism (2016) 7:35
Ypma RJF, Moseley RL, Holt RJ Rughooputh N,Floris DL, Chura LR, Spencer MD, Baron-Cohen S, Suckling J, Bullmore ET and Rubinov M (2016), “ Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum” Biol Psychiatry Cogn Neurosci Neuroimaging 2016 Jul; 1(4): 364–371.
Floris DL, Lai MC, Auer T, Lombardo MV, Ecker C, Chakrabarti B, Wheelwright S, AIMS MRC Consortium, Murphy D, Baron-Cohen, S, Suckling J (in press), “Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay ” Human Brain Mapping
Moseley RL, Ypma RJF, Holt RJ, Floris DL, Chura LR, Spencer MD, Baron-Cohen S, Suckling J, Bullmore E, Rubinov M (2015), “Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents” NeuroImage Clinical Volume 9, 140-152
Simas T, Chattopadhya S, Hagan C, Kundu P, Patel A, Holt RJ, Floris DL, Graham J, Ooi C, Tait R, Spencer MD, Baron-Cohen S, Sahakian B, Bullmore ET, Goodyer I, Suckling J (2015), “Semi-Metric Topology of the Human Connectome: Sensitivity and Specificity to Autism and Major Depressive Disorder” PlosOne Volume 10, Issue 8
Floris DL, Chura LR, Holt RJ, Suckling J, Bullmore ET, Baron-Cohen S, Spencer MD (2013), “Psychological correlates of handedness and corpus callosum asymmetry in autism: the left hemisphere dysfunction theory revisited.” J Autism Dev Disord 43(8):1758-72 Details