Professor Colin Taylor

Colin Taylor

University position

Professor

Professor Colin Taylor is pleased to consider applications from prospective PhD students.

Departments

Department of Pharmacology

Email

cwt1000@cam.ac.uk

Home page

http://www.phar.cam.ac.uk/researc...

Research Theme

Cellular and Molecular Neuroscience

Interests

Roles of inositol trisphosphate (IP3) receptors in generating intracellular calcium signals. Structural determinants of IP3 receptor behaviour. Decoding of calcium signals.

Research Focus

Keywords

calcium

ion channels

IP3 receptor

cell signalling

coding

Clinical conditions

Bipolar disorder

Cerebrovascular disorders

Diabetes

Epilepsy

Hormonal disorders

Huntington's disease

Equipment

Confocal imaging

Electronmicroscopy (EM)

Fluorescence polarization

Förster resonance energy transfer (FRET)

Molecular biology

Single channel recording

Single molecule fluorescence

Collaborators

No collaborators listed

Associated News Items


Key publications

Dellis, O, Dedos, SG, Tovey, SC, Rahman, U-T, Dubel, SJ, Taylor CW (2006), “Ca2+ entry through plasma membrane IP3 receptors” Science 313:229-233

Parker, AKT, Gergely, F, Taylor CW (2004), “Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains” J Biol Chem 279:23797-23805

daFonseca, PCA, Morris, SA, Nerou, EP, Taylor, CW & Morris, EP (2003), “Domain organisation of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single particle analysis” Proc Natl Acad USA 100:2936-3941

Publications

2014

Saleem H, Tovey SC, Molinski TF, Taylor CW (2014), “Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.” Br J Pharmacol 171(13):3298-312 Details

Taylor CW, Tovey SC, Rossi AM, Lopez Sanjurjo CI, Prole DL, Rahman T (2014), “Structural organization of signalling to and from IP3 receptors.” Biochem Soc Trans 42(1):63-70 Details

Thurley K, Tovey SC, Moenke G, Prince VL, Meena A, Thomas AP, Skupin A, Taylor CW, Falcke M (2014), “Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes.” Sci Signal 7(331):ra59 Details

2013

Chavda AP, Prole DL, Taylor CW (2013), “A bead aggregation assay for detection of low-affinity protein-protein interactions reveals interactions between N-terminal domains of inositol 1,4,5-trisphosphate receptors.” PLoS One 8(3):e60609 Details

Khan SA, Rossi AM, Riley AM, Potter BV, Taylor CW (2013), “Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain.” Biochem J 451(2):177-84 Details

Li C, Enomoto M, Rossi AM, Seo MD, Rahman T, Stathopulos PB, Taylor CW, Ikura M, Ames JB (2013), “CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.” Proc Natl Acad Sci U S A 110(21):8507-12 Details

López-Sanjurjo CI, Tovey SC, Prole DL, Taylor CW (2013), “Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.” J Cell Sci 126(Pt 1):289-300 Details

Pantazaka E, Taylor EJ, Bernard WG, Taylor CW (2013), “Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 and EP4 receptors in human aortic smooth muscle cells.” Br J Pharmacol 169(7):1624-34 Details

Prole DL, Taylor CW (2013), “Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa.” PLoS One 8(6):e66068 Details

Rossi AM, Taylor CW (2013), “High-throughput fluorescence polarization assay of ligand binding to IP3 receptors.” Cold Spring Harb Protoc 2013(10):938-46 Details

Saleem H, Tovey SC, Rahman T, Riley AM, Potter BV, Taylor CW (2013), “Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3.” PLoS One 8(1):e54877 Details

Saleem H, Tovey SC, Riley AM, Potter BV, Taylor CW (2013), “Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues.” PLoS One 8(2):e58027 Details

Saraiva N, Prole DL, Carrara G, Johnson BF, Taylor CW, Parsons M, Smith GL (2013), “hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.” J Cell Biol 202(4):699-713 Details

Saraiva N, Prole DL, Carrara G, Maluquer de Motes C, Johnson BF, Byrne B, Taylor CW, Smith GL (2013), “Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium.” J Biol Chem 288(18):13057-67 Details

Sun Y, Rossi AM, Rahman T, Taylor CW (2013), “Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.” Biochem J 449(1):39-49 Details

Taylor CW, Tovey SC, Rossi AM (2013), “High-throughput analyses of IP3 receptor behavior.” Cold Spring Harb Protoc 2013(10):914-7 Details

Tovey SC, Taylor CW (2013), “High-throughput functional assays of IP3-evoked Ca2+ release.” Cold Spring Harb Protoc 2013(10):930-7 Details

Tovey SC, Taylor CW (2013), “Cyclic AMP directs inositol (1,4,5)-trisphosphate-evoked Ca2+ signalling to different intracellular Ca2+ stores.” J Cell Sci 126(Pt 10):2305-13 Details

2012

Govindan S, Taylor CW (2012), “P2Y receptor subtypes evoke different Ca2+ signals in cultured aortic smooth muscle cells.” Purinergic Signal 8(4):763-77 Details

Konieczny V, Keebler MV, Taylor CW (2012), “Spatial organization of intracellular Ca2+ signals.” Semin Cell Dev Biol 23(2):172-80 Details

Prole DL, Taylor CW (2012), “Identification and analysis of cation channel homologues in human pathogenic fungi.” PLoS One 7(8):e42404 Details

Rossi AM, Tovey SC, Rahman T, Prole DL, Taylor CW (2012), “Analysis of IP3 receptors in and out of cells.” Biochim Biophys Acta 1820(8):1214-27 Details

Seo MD, Velamakanni S, Ishiyama N, Stathopulos PB, Rossi AM, Khan SA, Dale P, Li C, Ames JB, Ikura M, Taylor CW (2012), “Structural and functional conservation of key domains in InsP3 and ryanodine receptors.” Nature 483(7387):108-12 Details

Sureshan KM, Riley AM, Thomas MP, Tovey SC, Taylor CW, Potter BV (2012), “Contribution of phosphates and adenine to the potency of adenophostins at the IP₃ receptor: synthesis of all possible bisphosphates of adenophostin A.” J Med Chem 55(4):1706-20 Details

Taylor CW, Dale P (2012), “Intracellular Ca(2+) channels - a growing community.” Mol Cell Endocrinol 353(1-2):21-8 Details

Taylor CW, Prole DL (2012), “Ca(2+) Signalling by IP(3) Receptors.” Subcell Biochem 59:1-34 Details

Taylor CW, Tovey SC (2012), “From parathyroid hormone to cytosolic Ca2+ signals.” Biochem Soc Trans 40(1):147-52 Details

2011

Hooper R, Churamani D, Brailoiu E, Taylor CW, Patel S (2011), “Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.” J Biol Chem 286(11):9141-9 Details

Pantazaka E, Taylor CW (2011), “Differential distribution, clustering, and lateral diffusion of subtypes of the inositol 1,4,5-trisphosphate receptor.” J Biol Chem 286(26):23378-87 Details

Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E (2011), “The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.” Cell Calcium 50(2):157-67 Details

Prole DL, Taylor CW (2011), “Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites.” PLoS One 6(10):e26218 Details

Rossi AM, Taylor CW (2011), “Analysis of protein-ligand interactions by fluorescence polarization.” Nat Protoc 6(3):365-87 Details

Thurley K, Smith IF, Tovey SC, Taylor CW, Parker I, Falcke M (2011), “Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level.” Biophys J 101(11):2638-44 Details

2010

Brailoiu E, Rahman T, Churamani D, Prole DL, Brailoiu GC, Hooper R, Taylor CW, Patel S (2010), “An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.” J Biol Chem 285(49):38511-6 Details

Ding Z, Rossi AM, Riley AM, Rahman T, Potter BV, Taylor CW (2010), “Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.” Mol Pharmacol 77(6):995-1004 Details

Govindan S, Taylor EJ, Taylor CW (2010), “Ca(2+) signalling by P2Y receptors in cultured rat aortic smooth muscle cells.” Br J Pharmacol 160(8):1953-62 Details

Rahman T, Taylor CW (2010), “Nuclear patch-clamp recording from inositol 1,4,5-trisphosphate receptors.” Methods Cell Biol 99:199-224 Details

Rossi AM, Riley AM, Potter BV, Taylor CW (2010), “Adenophostins: High-Affinity Agonists of IP(3) Receptors.” Curr Top Membr 66C:209-33 Details

Rossi AM, Sureshan KM, Riley AM, Potter VL, Taylor CW (2010), “Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors.” Br J Pharmacol 161(5):1070-85 Details

Taylor CW, Tovey SC (2010), “IP(3) receptors: toward understanding their activation.” Cold Spring Harb Perspect Biol 2(12):a004010 Details

Tovey SC, Dedos SG, Rahman T, Taylor EJ, Pantazaka E, Taylor CW (2010), “Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.” J Biol Chem 285(17):12979-89 Details

Wolfram F, Morris E, Taylor CW (2010), “Three-dimensional structure of recombinant type 1 inositol 1,4,5-trisphosphate receptor.” Biochem J 428(3):483-9 Details

2009

Pantazaka E, Taylor CW (2009), “Targeting of inositol 1,4,5-trisphosphate receptor to the endoplasmic reticulum by its first transmembrane domain.” Biochem J 425(1):61-9 Details

Rahman T, Taylor CW (2009), “Dynamic regulation of IP3 receptor clustering and activity by IP3.” Channels (Austin) 3(4):226-32 Details

Rosker C, Meur G, Taylor EJ, Taylor CW (2009), “Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells.” J Biol Chem 284(8):5186-94 Details

Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, Taylor CW (2009), “Synthetic partial agonists reveal key steps in IP3 receptor activation.” Nat Chem Biol 5(9):631-9 Details

Sureshan KM, Riley AM, Rossi AM, Tovey SC, Dedos SG, Taylor CW, Potter BV (2009), “Activation of IP(3) receptors by synthetic bisphosphate ligands.” Chem Commun (Camb) (10):1204-6 Details

Taufiq-Ur-Rahman, Skupin A, Falcke M, Taylor CW (2009), “Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.” Nature 458(7238):655-9 Details

Taylor CW, Prole DL, Rahman T (2009), “Ca(2+) channels on the move.” Biochemistry 48(51):12062-80 Details

Taylor CW, Rahman T, Tovey SC, Dedos SG, Taylor EJ, Velamakanni S (2009), “IP3 receptors: some lessons from DT40 cells.” Immunol Rev 231(1):23-44 Details

Taylor CW, Taufiq-Ur-Rahman, Pantazaka E (2009), “Targeting and clustering of IP3 receptors: key determinants of spatially organized Ca2+ signals.” Chaos 19(3):037102 Details

2008

Dellis O, Rossi AM, Dedos SG, Taylor CW (2008), “Counting functional inositol 1,4,5-trisphosphate receptors into the plasma membrane.” J Biol Chem 283(2):751-5 Details

Skupin A, Kettenmann H, Winkler U, Wartenberg M, Sauer H, Tovey SC, Taylor CW, Falcke M (2008), “How does intracellular Ca2+ oscillate: by chance or by the clock?” Biophys J 94(6):2404-11 Details

Sun Y, Taylor CW (2008), “A calmodulin antagonist reveals a calmodulin-independent interdomain interaction essential for activation of inositol 1,4,5-trisphosphate receptors.” Biochem J 416(2):243-53 Details

Sureshan KM, Trusselle M, Tovey SC, Taylor CW, Potter BV (2008), “2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling.” J Org Chem 73(5):1682-92 Details

Tovey SC, Dedos SG, Taylor EJ, Church JE, Taylor CW (2008), “Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.” J Cell Biol 183(2):297-311 Details

2006

Dellis O, Dedos SG, Tovey SC, Taufiq-Ur-Rahman, Dubel SJ, Taylor CW (2006), “Ca2+ entry through plasma membrane IP3 receptors.” Science 313(5784):229-33 Details

Liu Y, Taylor CW (2006), “Stimulation of arachidonic acid release by vasopressin in A7r5 vascular smooth muscle cells mediated by Ca2+-stimulated phospholipase A2.” FEBS Lett 580(17):4114-20 Details

Mochizuki T, Kondo Y, Abe H, Taylor CW, Potter BV, Matsuda A, Shuto S (2006), “Design and synthesis of 5'-deoxy-5'-phenyladenophostin A, a highly potent IP3 receptor ligand.” Org Lett 8(7):1455-8 Details

Mochizuki T, Kondo Y, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Potter BV, Matsuda A, Shuto S (2006), “Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.” J Med Chem 49(19):5750-8 Details

Sureshan KM, Trusselle M, Tovey SC, Taylor CW, Potter BV (2006), “Guanophostin A: Synthesis and evaluation of a high affinity agonist of the D-myo-inositol 1,4,5-trisphosphate receptor.” Chem Commun (Camb) (19):2015-7 Details

Taylor CW (2006), “Store-operated Ca2+ entry: A STIMulating stOrai.” Trends Biochem Sci 31(11):597-601 Details

Taylor CW, Dellis O (2006), “Plasma membrane IP3 receptors.” Biochem Soc Trans 34(Pt 5):910-2 Details

Terauchi M, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Trusselle M, Potter BV, Matsuda A, Shuto S (2006), “A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.” J Med Chem 49(6):1900-9 Details

Tovey SC, Dedos SG, Taylor CW (2006), “Signalling from parathyroid hormone.” Biochem Soc Trans 34(Pt 4):515-7 Details

Tovey SC, Sun Y, Taylor CW (2006), “Rapid functional assays of intracellular Ca2+ channels.” Nat Protoc 1(1):259-63 Details

Woodcock NA, Taylor CW, Thornton S (2006), “Prostaglandin F2alpha increases the sensitivity of the contractile proteins to Ca2+ in human myometrium.” Am J Obstet Gynecol 195(5):1404-6 Details

2005

Borissow CN, Black SJ, Paul M, Tovey SC, Dedos SG, Taylor CW, Potter BV (2005), “Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity.” Org Biomol Chem 3(2):245-52 Details

Dyer JL, Liu Y, de la Huerga IP, Taylor CW (2005), “Long lasting inhibition of adenylyl cyclase selectively mediated by inositol 1,4,5-trisphosphate-evoked calcium release.” J Biol Chem 280(10):8936-44 Details

Laude AJ, Tovey SC, Dedos SG, Potter BV, Lummis SC, Taylor CW (2005), “Rapid functional assays of recombinant IP3 receptors.” Cell Calcium 38(1):45-51 Details

Moneer Z, Pino I, Taylor EJ, Broad LM, Liu Y, Tovey SC, Staali L, Taylor CW (2005), “Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells.” Biochem J 389(Pt 3):821-9 Details

Taylor CW, Tovey SC (2005), “What's in store for Ca2+ oscillations?” J Physiol 562(Pt 3):645 Details

2004

Parker AK, Gergely FV, Taylor CW (2004), “Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains.” J Biol Chem 279(22):23797-805 Details

Riley AM, Laude AJ, Taylor CW, Potter BV (2004), “Dimers of D-myo-inositol 1,4,5-trisphosphate: design, synthesis, and interaction with Ins(1,4,5)P3 receptors.” Bioconjug Chem 15(2):278-89 Details

Rossi AM, Taylor CW (2004), “Ca2+ regulation of inositol 1,4,5-trisphosphate receptors: can Ca2+ function without calmodulin?” Mol Pharmacol 66(2):199-203 Details

Taylor CW, da Fonseca PC, Morris EP (2004), “IP(3) receptors: the search for structure.” Trends Biochem Sci 29(4):210-9 Details

Taylor CW, Moneer Z (2004), “Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells.” Biol Res 37(4):641-5 Details

Woodcock NA, Taylor CW, Thornton S (2004), “Effect of an oxytocin receptor antagonist and rho kinase inhibitor on the [Ca++]i sensitivity of human myometrium.” Am J Obstet Gynecol 190(1):222-8 Details

2003

da Fonseca PC, Morris SA, Nerou EP, Taylor CW, Morris EP (2003), “Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single-particle analysis.” Proc Natl Acad Sci U S A 100(7):3936-41 Details

Moneer Z, Dyer JL, Taylor CW (2003), “Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin.” Biochem J 370(Pt 2):439-48 Details

Rosenberg HJ, Riley AM, Laude AJ, Taylor CW, Potter BV (2003), “Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction.” J Med Chem 46(23):4860-71 Details

Taylor CW (2003), “What works. Bridging the gap. In-home monitoring device reduces cost of treating underserved populations in rural Alabama.” Health Manag Technol 24(4):36-8 Details

Tovey SC, Goraya TA, Taylor CW (2003), “Parathyroid hormone increases the sensitivity of inositol trisphosphate receptors by a mechanism that is independent of cyclic AMP.” Br J Pharmacol 138(1):81-90 Details

Turvey MR, Laude AJ, Ives EO, Seager WH, Taylor CW, Thorn P (2003), “Modulation of IP(3)-sensitive Ca(2+) release by 2,3-butanedione monoxime.” Pflugers Arch 445(5):614-21 Details

Wagner GK, Riley AM, Rosenberg HJ, Taylor CW, Guse AH, Potter BV (2003), “Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction.” Nucleic Acids Res Suppl (3):1-2 Details

2002

Kidd JF, Pilkington MF, Schell MJ, Fogarty KE, Skepper JN, Taylor CW, Thorn P (2002), “Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore.” J Biol Chem 277(8):6504-10 Details

Moneer Z, Taylor CW (2002), “Reciprocal regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells: only the latter operates during receptor activation.” Biochem J 362(Pt 1):13-21 Details

Morris SA, Nerou EP, Riley AM, Potter BV, Taylor CW (2002), “Determinants of adenophostin A binding to inositol trisphosphate receptors.” Biochem J 367(Pt 1):113-20 Details

Riley AM, Morris SA, Nerou EP, Correa V, Potter BV, Taylor CW (2002), “Interactions of inositol 1,4,5-trisphosphate (IP(3)) receptors with synthetic poly(ethylene glycol)-linked dimers of IP(3) suggest close spacing of the IP(3)-binding sites.” J Biol Chem 277(43):40290-5 Details

Swatton JE, Taylor CW (2002), “Fast biphasic regulation of type 3 inositol trisphosphate receptors by cytosolic calcium.” J Biol Chem 277(20):17571-9 Details

Taylor CW (2002), “Controlling calcium entry.” Cell 111(6):767-9 Details

Taylor CW (2002), “Regulation of Ca2+ entry pathways by both limbs of the phosphoinositide pathway.” Novartis Found Symp 246:91-101; discussion 101-7, 221-7 Details

Taylor CW, Laude AJ (2002), “IP3 receptors and their regulation by calmodulin and cytosolic Ca2+.” Cell Calcium 32(5-6):321-34 Details

Theodoropoulos G, Wise WE, Padmanabhan A, Kerner BA, Taylor CW, Aguilar PS, Khanduja KS (2002), “T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival.” Dis Colon Rectum 45(7):895-903 Details

Wissing F, Nerou EP, Taylor CW (2002), “A novel Ca2+-induced Ca2+ release mechanism mediated by neither inositol trisphosphate nor ryanodine receptors.” Biochem J 361(Pt 3):605-11 Details

2001

Correa V, Riley AM, Shuto S, Horne G, Nerou EP, Marwood RD, Potter BV, Taylor CW (2001), “Structural determinants of adenophostin A activity at inositol trisphosphate receptors.” Mol Pharmacol 59(5):1206-15 Details

Nerou EP, Riley AM, Potter BV, Taylor CW (2001), “Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor.” Biochem J 355(Pt 1):59-69 Details

Riley AM, Correa V, Mahon MF, Taylor CW, Potter BV (2001), “Bicyclic analogues of D-myo-inositol 1,4,5-trisphosphate related to adenophostin A: synthesis and biological activity.” J Med Chem 44(13):2108-17 Details

Rosenberg HJ, Riley AM, Marwood RD, Correa V, Taylor CW, Potter BVL (2001), “Xylopyranoside-based agonists of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and effect of stereochemistry on biological activity.” Carbohydr Res 332(1):53-66 Details

Swatton JE, Morris SA, Wissing F, Taylor CW (2001), “Functional properties of Drosophila inositol trisphosphate receptors.” Biochem J 359(Pt 2):435-41 Details

Taylor CW, Thorn P (2001), “Calcium signalling: IP3 rises again...and again.” Curr Biol 11(9):R352-5 Details

Wang Y, Chen J, Wang Y, Taylor CW, Hirata Y, Hagiwara H, Mikoshiba K, Toyo-oka T, Omata M, Sakaki Y (2001), “Crucial role of type 1, but not type 3, inositol 1,4,5-trisphosphate (IP(3)) receptors in IP(3)-induced Ca(2+) release, capacitative Ca(2+) entry, and proliferation of A7r5 vascular smooth muscle cells.” Circ Res 88(2):202-9 Details

2000

Adkins CE, Morris SA, De Smedt H, Sienaert I, Török K, Taylor CW (2000), “Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.” Biochem J 345 Pt 2:357-63 Details

Adkins CE, Wissing F, Potter BV, Taylor CW (2000), “Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A.” Biochem J 352 Pt 3:929-33 Details

de Kort M, Correa V, Valentijn AR, van der Marel GA, Potter BV, Taylor CW, van Boom JH (2000), “Synthesis of potent agonists of the D-myo-inositol 1,4, 5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A.” J Med Chem 43(17):3295-303 Details

Marwood RD, Jenkins DJ, Correa V, Taylor CW, Potter BV (2000), “Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy.” J Med Chem 43(22):4278-87 Details

Rosenberg HJ, Riley AM, Correa V, Taylor CW, Potter BV (2000), “C-glycoside based mimics of D-myo-inositol 1,4,5-trisphosphate.” Carbohydr Res 329(1):7-16 Details

Short AD, Taylor CW (2000), “Parathyroid hormone controls the size of the intracellular Ca(2+) stores available to receptors linked to inositol trisphosphate formation.” J Biol Chem 275(3):1807-13 Details

Short AD, Winston GP, Taylor CW (2000), “Different receptors use inositol trisphosphate to mobilize Ca(2+) from different intracellular pools.” Biochem J 351 Pt 3:683-6 Details

Tasker PN, Taylor CW, Nixon GF (2000), “Expression and distribution of InsP(3) receptor subtypes in proliferating vascular smooth muscle cells.” Biochem Biophys Res Commun 273(3):907-12 Details

1999

Adkins CE, Taylor CW (1999), “Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca(2+).” Curr Biol 9(19):1115-8 Details

Beecroft MD, Marchant JS, Riley AM, Van Straten NC, Van der Marel GA, Van Boom JH, Potter BV, Taylor CW (1999), “Acyclophostin: a ribose-modified analog of adenophostin A with high affinity for inositol 1,4,5-trisphosphate receptors and pH-dependent efficacy.” Mol Pharmacol 55(1):109-17 Details

Broad LM, Cannon TR, Short AD, Taylor CW (1999), “Receptors linked to polyphosphoinositide hydrolysis stimulate Ca2+ extrusion by a phospholipase C-independent mechanism.” Biochem J 342 ( Pt 1):199-206 Details

Broad LM, Cannon TR, Taylor CW (1999), “A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin.” J Physiol 517 ( Pt 1):121-34 Details

Marwood RD, Riley AM, Correa V, Taylor CW, Potter BV (1999), “Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate.” Bioorg Med Chem Lett 9(3):453-8 Details

McKillen K, Thornton S, Taylor CW (1999), “Oxytocin increases the [Ca2+]i sensitivity of human myometrium during the falling phase of phasic contractions.” Am J Physiol 276(2 Pt 1):E345-51 Details

McNulty TJ, Taylor CW (1999), “Extracellular heavy-metal ions stimulate Ca2+ mobilization in hepatocytes.” Biochem J 339 ( Pt 3):555-61 Details

Morris SA, Correa V, Cardy TJ, O'Beirne G, Taylor CW (1999), “Interactions between inositol trisphosphate receptors and fluorescent Ca2+ indicators.” Cell Calcium 25(2):137-42 Details

Snitsarev VA, Taylor CW (1999), “Overshooting cytosolic Ca2+ signals evoked by capacitative Ca2+ entry result from delayed stimulation of a plasma membrane Ca2+ pump.” Cell Calcium 25(6):409-17 Details

Swatton JE, Morris SA, Cardy TJ, Taylor CW (1999), “Type 3 inositol trisphosphate receptors in RINm5F cells are biphasically regulated by cytosolic Ca2+ and mediate quantal Ca2+ mobilization.” Biochem J 344 Pt 1:55-60 Details

Taylor CW, Genazzani AA, Morris SA (1999), “Expression of inositol trisphosphate receptors.” Cell Calcium 26(6):237-51 Details

1998

Beecroft MD, Taylor CW (1998), “Luminal Ca2+ regulates passive Ca2+ efflux from the intracellular stores of hepatocytes.” Biochem J 334 ( Pt 2):431-5 Details

Cardy TJ, Taylor CW (1998), “A novel role for calmodulin: Ca2+-independent inhibition of type-1 inositol trisphosphate receptors.” Biochem J 334 ( Pt 2):447-55 Details

Marchant JS, Taylor CW (1998), “Rapid activation and partial inactivation of inositol trisphosphate receptors by inositol trisphosphate.” Biochemistry 37(33):11524-33 Details

Taylor CW (1998), “Inositol trisphosphate receptors: Ca2+-modulated intracellular Ca2+ channels.” Biochim Biophys Acta 1436(1-2):19-33 Details

Taylor CW, Broad LM (1998), “Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls.” Trends Pharmacol Sci 19(9):370-5 Details

Ukhanov K, Ukhanova M, Taylor CW, Payne R (1998), “Putative inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in Limulus photoreceptors.” Neuroscience 86(1):23-8 Details

1997

Beecroft MD, Taylor CW (1997), “Incremental Ca2+ mobilization by inositol trisphosphate receptors is unlikely to be mediated by their desensitization or regulation by luminal or cytosolic Ca2+.” Biochem J 326 ( Pt 1):215-20 Details

Cardy TJ, Traynor D, Taylor CW (1997), “Differential regulation of types-1 and -3 inositol trisphosphate receptors by cytosolic Ca2+.” Biochem J 328 ( Pt 3):785-93 Details

Madge L, Marshall IC, Taylor CW (1997), “Delayed autoregulation of the Ca2+ signals resulting from capacitative Ca2+ entry in bovine pulmonary artery endothelial cells.” J Physiol 498 ( Pt 2):351-69 Details

Marchant JS, Beecroft MD, Riley AM, Jenkins DJ, Marwood RD, Taylor CW, Potter BV (1997), “Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.” Biochemistry 36(42):12780-90 Details

Marchant JS, Chang YT, Chung SK, Irvine RF, Taylor CW (1997), “Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors.” Biochem J 321 ( Pt 3):573-6 Details

Marchant JS, Taylor CW (1997), “Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity.” Curr Biol 7(7):510-8 Details

Patel S, Morris SA, Adkins CE, O'Beirne G, Taylor CW (1997), “Ca2+-independent inhibition of inositol trisphosphate receptors by calmodulin: redistribution of calmodulin as a possible means of regulating Ca2+ mobilization.” Proc Natl Acad Sci U S A 94(21):11627-32 Details

1996

Broad LM, Powis DA, Taylor CW (1996), “Differentiation of BC3H1 smooth muscle cells changes the bivalent cation selectivity of the capacitative Ca2+ entry pathway.” Biochem J 316 ( Pt 3):759-64 Details

Combettes L, Cheek TR, Taylor CW (1996), “Regulation of inositol trisphosphate receptors by luminal Ca2+ contributes to quantal Ca2+ mobilization.” EMBO J 15(9):2086-93 Details

Hargreaves AC, Gunthorpe MJ, Taylor CW, Lummis SC (1996), “Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.” Mol Pharmacol 50(5):1284-94 Details

Patel S, Harris A, O'Beirne G, Cook ND, Taylor CW (1996), “Kinetic analysis of inositol trisphosphate binding to pure inositol trisphosphate receptors using scintillation proximity assay.” Biochem Biophys Res Commun 221(3):821-5 Details

Snitsarev VA, McNulty TJ, Taylor CW (1996), “Endogenous heavy metal ions perturb fura-2 measurements of basal and hormone-evoked Ca2+ signals.” Biophys J 71(2):1048-56 Details

1995

Byron K, Taylor CW (1995), “Vasopressin stimulation of Ca2+ mobilization, two bivalent cation entry pathways and Ca2+ efflux in A7r5 rat smooth muscle cells.” J Physiol 485 ( Pt 2):455-68 Details

Patel S, Taylor CW (1995), “Quantal responses to inositol 1,4,5-trisphosphate are not a consequence of Ca2+ regulation of inositol 1,4,5-trisphosphate receptors.” Biochem J 312 ( Pt 3):789-94 Details

Taylor CW (1995), “Why do hormones stimulate Ca2+ mobilization?” Biochem Soc Trans 23(3):637-42 Details

Taylor CW, Traynor D (1995), “Calcium and inositol trisphosphate receptors.” J Membr Biol 145(2):109-18 Details

1994

Dasso LL, Taylor CW (1994), “Interactions between Ca(2+)-mobilizing receptors and their G proteins in hepatocytes.” J Biol Chem 269(12):8647-52 Details

Hargreaves AC, Lummis SC, Taylor CW (1994), “Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors.” Mol Pharmacol 46(6):1120-8 Details

Marshall IC, Taylor CW (1994), “Two calcium-binding sites mediate the interconversion of liver inositol 1,4,5-trisphosphate receptors between three conformational states.” Biochem J 301 ( Pt 2):591-8 Details

Taylor CW (1994), “Ca2+ sparks a wave of excitement.” Trends Pharmacol Sci 15(8):271-4 Details

1993

Byron KL, Taylor CW (1993), “Spontaneous Ca2+ spiking in a vascular smooth muscle cell line is independent of the release of intracellular Ca2+ stores.” J Biol Chem 268(10):6945-52 Details

Jenkins AL, Bootman MD, Taylor CW, Mackie EJ, Stone SR (1993), “Characterization of the receptor responsible for thrombin-induced intracellular calcium responses in osteoblast-like cells.” J Biol Chem 268(28):21432-7 Details

Marshall IC, Taylor CW (1993), “Regulation of inositol 1,4,5-trisphosphate receptors.” J Exp Biol 184:161-82 Details

Marshall IC, Taylor CW (1993), “Biphasic effects of cytosolic Ca2+ on Ins(1,4,5)P3-stimulated Ca2+ mobilization in hepatocytes.” J Biol Chem 268(18):13214-20 Details

McNulty TJ, Taylor CW (1993), “Caffeine-stimulated Ca2+ release from the intracellular stores of hepatocytes is not mediated by ryanodine receptors.” Biochem J 291 ( Pt 3):799-801 Details

Oldershaw KA, Taylor CW (1993), “Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor.” Biochem J 292 ( Pt 3):631-3 Details

Richardson A, Taylor CW (1993), “Effects of Ca2+ chelators on purified inositol 1,4,5-trisphosphate (InsP3) receptors and InsP3-stimulated Ca2+ mobilization.” J Biol Chem 268(16):11528-33 Details

1992

Bootman MD, Berridge MJ, Taylor CW (1992), “All-or-nothing Ca2+ mobilization from the intracellular stores of single histamine-stimulated HeLa cells.” J Physiol 450:163-78 Details

Bootman MD, Taylor CW, Berridge MJ (1992), “The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor.” J Biol Chem 267(35):25113-9 Details

Dasso LL, Taylor CW (1992), “Different calcium-mobilizing receptors share the same guanine nucleotide-binding protein pool in hepatocytes.” Mol Pharmacol 42(3):453-7 Details

Dasso LL, Taylor CW (1992), “Effects of polyanions on alpha 1-adrenoceptor-G protein interactions.” Biochem Soc Trans 20(2):134S Details

Missiaen L, Taylor CW, Berridge MJ (1992), “Pyrophosphatase-induced Ca2+ release is unrelated to the spontaneous release from inositol 1,4,5-trisphosphate-sensitive Ca2+ stores.” Biochem J 282 ( Pt 1):306-8 Details

Nunn DL, Taylor CW (1992), “Luminal Ca2+ increases the sensitivity of Ca2+ stores to inositol 1,4,5-trisphosphate.” Mol Pharmacol 41(1):115-9 Details

Oldershaw KA, Richardson A, Taylor CW (1992), “Prolonged exposure to inositol 1,4,5-trisphosphate does not cause intrinsic desensitization of the intracellular Ca(2+)-mobilizing receptor.” J Biol Chem 267(23):16312-6 Details

Taylor CW (1992), “Kinetics of inositol 1,4,5-trisphosphate-stimulated Ca2+ mobilization.” Adv Second Messenger Phosphoprotein Res 26:109-42 Details

Taylor CW, Marshall IC (1992), “Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship.” Trends Biochem Sci 17(10):403-7 Details

1991

Bond JM, Taylor CW (1991), “Solubilization of rat liver inositol 1,4,5-trisphosphate receptor.” Cell Signal 3(6):607-12 Details

Dasso LL, Taylor CW (1991), “Heparin and other polyanions uncouple alpha 1-adrenoceptors from G-proteins.” Biochem J 280 ( Pt 3):791-5 Details

Missiaen L, Taylor CW, Berridge MJ (1991), “Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores.” Nature 352(6332):241-4 Details

Nunn DL, Taylor CW (1991), “Regulation of Ca2+ mobilization by Ins (1,4,5)P3 and intraluminal Ca2+ in permeabilized hepatocytes.” Biochem Soc Trans 19(2):206S Details

Oldershaw KA, Nunn DL, Taylor CW (1991), “Quantal Ca2+ mobilization stimulated by inositol 1,4,5-trisphosphate in permeabilized hepatocytes.” Biochem J 278 ( Pt 3):705-8 Details

Taylor CW, Richardson A (1991), “Structure and function of inositol trisphosphate receptors.” Pharmacol Ther 51(1):97-137 Details

1990

Nunn DL, Potter BV, Taylor CW (1990), “Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum.” Biochem J 265(2):393-8 Details

Nunn DL, Taylor CW (1990), “Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors.” Biochem J 270(1):227-32 Details

Oldershaw KA, Taylor CW (1990), “2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-trisphosphate-sensitive and -insensitive Ca2+ stores.” FEBS Lett 274(1-2):214-6 Details

Taylor CW (1990), “The role of G proteins in transmembrane signalling.” Biochem J 272(1):1-13 Details

Taylor CW (1990), “Receptor-regulated Ca2+ entry: secret pathway or secret messenger?” Trends Pharmacol Sci 11(7):269-71 Details

Taylor CW, Potter BV (1990), “The size of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores depends on inositol 1,4,5-trisphosphate concentration.” Biochem J 266(1):189-94 Details

1989

Taylor CW, Berridge MJ, Cooke AM, Potter BV (1989), “Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium.” Biochem J 259(3):645-50 Details

1988

Berridge MJ, Taylor CW (1988), “Inositol trisphosphate and calcium signaling.” Cold Spring Harb Symp Quant Biol 53 Pt 2:927-33 Details

Taylor CW (1988), “Time and space--novel aspects of hormone action.” Trends Pharmacol Sci 9(2):43-5 Details

Taylor CW, Berridge MJ, Brown KD, Cooke AM, Potter BV (1988), “DL-myo-inositol 1,4,5-trisphosphorothioate mobilizes intracellular calcium in Swiss 3T3 cells and Xenopus oocytes.” Biochem Biophys Res Commun 150(2):626-32 Details

Taylor CW, Blakeley DM, Brown KD (1988), “Guanine nucleotides stimulate hydrolysis of phosphatidylinositol and polyphosphoinositides in permeabilized Swiss 3T3 cells.” FEBS Lett 237(1-2):163-7 Details

Taylor CW, Blakeley DM, Corps AN, Berridge MJ, Brown KD (1988), “Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells.” Biochem J 249(3):917-20 Details

1987

Wilson HA, Greenblatt D, Taylor CW, Putney JW, Tsien RY, Finkelman FD, Chused TM (1987), “The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor.” J Immunol 138(6):1712-8 Details

1986

Merritt JE, Taylor CW, Rubin RP, Putney JW Jr (1986), “Isomers of inositol trisphosphate in exocrine pancreas.” Biochem J 238(3):825-9 Details

Merritt JE, Taylor CW, Rubin RP, Putney JW Jr (1986), “Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.” Biochem J 236(2):337-43 Details

Putney JW Jr, Aub DL, Taylor CW, Merritt JE (1986), “Formation and biological action of inositol 1,4,5-trisphosphate.” Fed Proc 45(11):2634-8 Details

Taylor CW, Merritt JE, Putney JW Jr, Rubin RP (1986), “Effects of Ca2+ on phosphoinositide breakdown in exocrine pancreas.” Biochem J 238(3):765-72 Details

Taylor CW, Merritt JE, Putney JW Jr, Rubin RP (1986), “A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland.” Biochem Biophys Res Commun 136(1):362-8 Details

Taylor CW, Putney JW (1986), “Receptor regulation of phosphoinositide and calcium metabolism.” Proc West Pharmacol Soc 29:307-9 Details

1985

Taylor CW (1985), “Calcium regulation in blowflies: absence of a role for midgut.” Am J Physiol 249(2 Pt 2):R209-13 Details

Taylor CW, Putney JW Jr (1985), “Size of the inositol 1,4,5-trisphosphate-sensitive calcium pool in guinea-pig hepatocytes.” Biochem J 232(2):435-8 Details

1984

Taylor CW (1984), “Transcellular calcium transport by the midgut of the blowfly, Calliphora vicina.” Cell Calcium 5(4):377-90 Details