Mr Bastiaan Bijleveld

Interests

My current project involves investigating the neural substrates of obsessive-compulsive disorder (OCD). One particular region of interest for us is the ventromedial prefrontal cortex (vmPFC). This brain region has a central multifaceted role in OCD pathology, and our aim is to investigate this putative role of the vmPFC in regard to large-scale neuronal networks.

Using a resting state functional connectivity analysis, we hope to elucidate how the ventromedial prefrontal cortex relates to core OCD pathology, such as the thalamo-cortico-striatal circuitry, and frontoparietal networks.

Other projects involve the acquisition of cognitive measurements in patients with OCD, and looking at white matter tracts using diffusion tensor imaging (DTI).

Resting state hyperconnectivity from vmPFC to caudate in patients with OCD
Resting state hyperconnectivity from vmPFC to caudate in patients with OCD
Click image to view full-size

Research Focus

Keywords

OCD

Resting state

vmPFC

Cognitive flexibility

SPM/FSL/Freesurfer

Clinical conditions

Obsessive compulsive disorder

Equipment

Diffusion tensor imaging

Magnetic resonance imaging (MRI)

Neuropsychological testing

Resting state functional connectivity analysis

Collaborators

Cambridge

Annemieke Apergis-Schoute

Trevor Robbins

Barbara Sahakian

Matilde Vaghi

Associated News Items