Dr Annemieke Apergis-Schoute
I study how humans acquire emotions, in particular fear, and most importantly how to extinguish negative memories or how to have control over negative states. I did my PhD at New York University where I studied with Professor Joseph LeDoux & Professor Elizabeth Phelps, both experts on emotional learning, going from rat behaviour & electrophysiology to investigating human fear learning using fMRI and galvanic skin conductance recordings. Currently I am a postdoc with Professor Trevor Robbins focusing on the interactions between the prefrontal cortex and the amygdala during cognitive control over emotions. We also investigate how an imbalance in these functional connections can lead to a range of mental disorders such as depression and disorders related to impulsive behaviour.
Attention deficit hyperactivity disorder
Post-traumatic stress disorder
Galvanic Skin Conductance and Heart Rate measurements.
Magnetic resonance imaging (MRI)
Apergis-Schoute AM, Schiller D, LeDoux JE, Phelps EA (2014), “Extinction resistant changes in the human auditory association cortex following threat learning.” Neurobiol Learn Mem 113:109-14 Details
Ersche KD, Hagan CC, Smith DG, Abbott S, Jones PS, Apergis-Schoute AM, Döffinger R (2014), “Aberrant disgust responses and immune reactivity in cocaine-dependent men.” Biol Psychiatry 75(2):140-7 Details
Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM, Fineberg NA, Sahakian BJ, Robbins TW (2014), “Enhanced avoidance habits in obsessive-compulsive disorder.” Biol Psychiatry 75(8):631-8 Details
Crockett MJ, Apergis-Schoute A, Herrmann B, Lieberman MD, Müller U, Robbins TW, Clark L (2013), “Serotonin modulates striatal responses to fairness and retaliation in humans.” J Neurosci 33(8):3505-13 Details
Crockett MJ, Clark L, Apergis-Schoute AM, Morein-Zamir S, Robbins TW (2012), “Serotonin modulates the effects of Pavlovian aversive predictions on response vigor.” Neuropsychopharmacology 37(10):2244-52 Details
Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, Ouden Hd, Apergis-Schoute A, Campbell-Meiklejohn D, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012), “Converging evidence for central 5-HT effects in acute tryptophan depletion.” Mol Psychiatry 17(2):121-3 Details
Passamonti L, Crockett MJ, Apergis-Schoute AM, Clark L, Rowe JB, Calder AJ, Robbins TW (2012), “Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.” Biol Psychiatry 71(1):36-43 Details
Studer B, Apergis-Schoute AM, Robbins TW, Clark L (2012), “What are the Odds? The Neural Correlates of Active Choice during Gambling.” Front Neurosci 6:46 Details
Apergis-Schoute AM, Debiec J, Doyère V, LeDoux JE, Schafe GE (2005), “Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear system.” J Neurosci 25(24):5730-9 Details