Dr Annemieke Apergis-Schoute

Annemieke Apergis-Schoute

University position

Research Associate

Departments

Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Research Theme

Cognitive and Behavioural Neuroscience

Interests

I study how humans acquire emotions, in particular fear, and most importantly how to extinguish negative memories or how to have control over negative states. I did my PhD at New York University where I studied with Professor Joseph LeDoux & Professor Elizabeth Phelps, both experts on emotional learning, going from rat behaviour & electrophysiology to investigating human fear learning using fMRI and galvanic skin conductance recordings. Currently I am a postdoc with Professor Trevor Robbins focusing on the interactions between the prefrontal cortex and the amygdala during cognitive control over emotions. We also investigate how an imbalance in these functional connections can lead to a range of mental disorders such as depression and disorders related to impulsive behaviour.

Research Focus

Keywords

prefrontal cortex

amygdala

emotional learning

cognitive control

fmri

Clinical conditions

Anxiety disorders

Attention deficit hyperactivity disorder

Depressive disorders

Post-traumatic stress disorder

Stress

Equipment

Behavioural analysis

Galvanic Skin Conductance and Heart Rate measurements.

Magnetic resonance imaging (MRI)

Collaborators

Cambridge

Molly Crockett

Bettina Studer

Publications

2014

Apergis-Schoute AM, Schiller D, LeDoux JE, Phelps EA (2014), “Extinction resistant changes in the human auditory association cortex following threat learning.” Neurobiol Learn Mem 113:109-14 Details

Ersche KD, Hagan CC, Smith DG, Abbott S, Jones PS, Apergis-Schoute AM, Döffinger R (2014), “Aberrant disgust responses and immune reactivity in cocaine-dependent men.” Biol Psychiatry 75(2):140-7 Details

Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM, Fineberg NA, Sahakian BJ, Robbins TW (2014), “Enhanced avoidance habits in obsessive-compulsive disorder.” Biol Psychiatry 75(8):631-8 Details

2013

Crockett MJ, Apergis-Schoute A, Herrmann B, Lieberman MD, Müller U, Robbins TW, Clark L (2013), “Serotonin modulates striatal responses to fairness and retaliation in humans.” J Neurosci 33(8):3505-13 Details

2012

Crockett MJ, Clark L, Apergis-Schoute AM, Morein-Zamir S, Robbins TW (2012), “Serotonin modulates the effects of Pavlovian aversive predictions on response vigor.” Neuropsychopharmacology 37(10):2244-52 Details

Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, Ouden Hd, Apergis-Schoute A, Campbell-Meiklejohn D, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012), “Converging evidence for central 5-HT effects in acute tryptophan depletion.” Mol Psychiatry 17(2):121-3 Details

Passamonti L, Crockett MJ, Apergis-Schoute AM, Clark L, Rowe JB, Calder AJ, Robbins TW (2012), “Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.” Biol Psychiatry 71(1):36-43 Details

Studer B, Apergis-Schoute AM, Robbins TW, Clark L (2012), “What are the Odds? The Neural Correlates of Active Choice during Gambling.” Front Neurosci 6:46 Details

2005

Apergis-Schoute AM, Debiec J, Doyère V, LeDoux JE, Schafe GE (2005), “Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear system.” J Neurosci 25(24):5730-9 Details