Dr Andrew Lawrence

University position

Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Stroke Research Group and Neurology Unit

Email

ajl54@medschl.cam.ac.uk

Research Theme

Cognitive and Behavioural Neuroscience

Interests

I am a psychologist with interests in the application of neuropsychological testing and advanced MRI techniques to understand cognitive function and dysfunction. I am currently investigating cognitive decline and MRI markers of pathology associated with vascular disease. My recent work applies structural and functional network models to MRI data with an aim to better understand this cognitive decline in cerebral small vessel disease/stroke. I completed my doctoral research at the University of Cambridge which focused on impulsivity in addiction. This involved assessing multiple varieties, or factors, of impulsivity in alcohol dependent individuals, problem and pathological gamblers, mediation-induced repetitive behaviours in Parkinson’s disease and serial entrepreneurs (as functional risk-takers).

Research Focus

Keywords

Neuropsychology

Structural MRI

Diffusion Imaging

Structural & Functional Brain Networks

Graph Analysis

Clinical conditions

Alzheimer's disease

Cognitive impairment

Dementia

Stroke

Vascular Cognitive Impairment

Equipment

Cross-sectional and cohort studies

Neuropsychological testing

Collaborators

Cambridge

Hugh Markus

Guy Williams

United Kingdom

Thomas Barrick Web: http://www.sgul.ac.uk/researc...

Associated News Items


    Key publications

    Tuladhar AM, van Uden IW, Rutten-Jacobs LC, Lawrence A, van der Holst H, van Norden A, de Laat K, van Dijk E, Claassen JA, Kessels RP, Markus HS, Norris DG, de Leeuw FE (2016), “Structural network efficiency predicts conversion to dementia” Neurology 86(12):1112-9

    Hollocks MJ, Lawrence AJ, Brookes RL, Barrick TR, Morris RG, Husain M, Markus HS (2015), “Differential relationships between apathy and depression with white matter microstructural changes and functional outcomes” Brain 138(12): 3803-15

    Lawrence AJ, Brookes RL, Zeestraten EA, Barrick TR, Morris RG, Markus HS (2015), “Pattern and Rate of Cognitive Decline in Cerebral Small Vessel Disease: A Prospective Study” PLoS One 10(8): e0135523

    Lawrence AJ, Chung AW, Morris RG, Markus HS, Barrick TR. (2014), “Structural network efficiency is associated with cognitive impairment in small-vessel disease.” Neurology 83(4): 304-11

    Lawrence AJ, Patel B, Morris RG, MacKinnon AD, Rich PM, Barrick TR, Markus HS (2013), “Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study.” PLoS One 8(4):e61014 Details

    Publications

    2016

    Lambert C, Benjamin P, Zeestraten E, Lawrence AJ, Barrick TR, Markus HS (2016), “Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease” Brain 139(4): 1136-51

    Zeestraten EA, Benjamin P, Lambert C, Lawrence AJ, Williams OA, Morris RG, Barrick TR, Markus HS (2016), “Application of Diffusion Tensor Imaging Parameters to Detect Change in Longitudinal Studies in Cerebral Small Vessel Disease” PLoS One 11(1):e0147836

    2015

    Benjamin P, Zeestraten E, Lambert C, Ster IC, Williams OA, Lawrence AJ, Patel B, MacKinnon AD, Barrick TR, Markus HS (2015), “Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials” J Cereb Blood Flow Metab. 36(1): 228-40

    2014

    Benjamin P, Lawrence AJ, Lambert C, Patel B, Chung AW, MacKinnon AD, Morris RG, Barrick TR, Markus HS (2014), “Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease” Neuroimage Clin. 4: 828-37

    Bridges LR, Andoh J, Lawrence AJ, Khoong CH, Poon WW, Esiri MM, Markus HS, Hainsworth AH (2014), “Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people” J Neuropathol Exp Neurol. 73(11): 1026-33

    Brookes RL, Herbert V, Lawrence AJ, Morris RG, Markus HS (2014), “Depression in small-vessel disease relates to white matter ultrastructural damage, not disability” Neurology 83(16): 1417-23

    2013

    Patel B, Lawrence AJ, Chung AW, Rich P, Mackinnon AD, Morris RG, Barrick TR, Markus HS (2013), “Cerebral microbleeds and cognition in patients with symptomatic small vessel disease.” Stroke 44(2):356-61 Details

    2009

    Clark L, Lawrence AJ, Astley-Jones F, Gray N (2009), “Gambling near-misses enhance motivation to gamble and recruit win-related brain circuitry.” Neuron 61(3):481-90 Details

    Lawrence AJ, Luty J, Bogdan NA, Sahakian BJ, Clark L (2009), “Impulsivity and response inhibition in alcohol dependence and problem gambling.” Psychopharmacology (Berl) 207(1):163-72 Details

    Lawrence AJ, Luty J, Bogdan NA, Sahakian BJ, Clark L (2009), “Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals.” Addiction 104(6):1006-15 Details

    2008

    Lawrence A, Clark L, Labuzetta JN, Sahakian B, Vyakarnum S (2008), “The innovative brain.” Nature 456(7219):168-9 Details

    Verdejo-GarcĂ­a A, Lawrence AJ, Clark L (2008), “Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies.” Neurosci Biobehav Rev 32(4):777-810 Details

    2007

    Lawrence AJ et al (2007), “Predictors of Punding in Parkinson's Disease: Results from a Questionnaire Survey” Movement Disorders 22(16):2339-2345

    Lawrence AJ, Blackwell AD, Barker RA, Spagnolo F, Clark L, Aitken MR, Sahakian BJ (2007), “Predictors of punding in Parkinson's disease: results from a questionnaire survey.” Mov Disord 22(16):2339-45 Details